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Pyrimidine metabolism information


Pyrimidine biosynthesis occurs both in the body and through organic synthesis.[1]

  1. ^ Alqahtani, Saad Saeed; Koltai, Tomas; Ibrahim, Muntaser E.; Bashir, Adil H. H.; Alhoufie, Sari T. S.; Ahmed, Samrein B. M.; Molfetta, Daria Di; Carvalho, Tiago M. A.; Cardone, Rosa Angela; Reshkin, Stephan Joel; Hifny, Abdelhameed; Ahmed, Mohamed E.; Alfarouk, Khalid Omer (6 July 2022). "Role of pH in Regulating Cancer Pyrimidine Synthesis". Journal of Xenobiotics. 12 (3): 158–180. doi:10.3390/jox12030014. PMC 9326563.

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Pyrimidine metabolism

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Pyrimidine biosynthesis occurs both in the body and through organic synthesis. De Novo biosynthesis of a pyrimidine is catalyzed by three gene products...

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Pyrimidine

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Pyrimidine (C4H4N2; /pɪˈrɪ.mɪˌdiːn, paɪˈrɪ.mɪˌdiːn/) is an aromatic, heterocyclic, organic compound similar to pyridine (C5H5N). One of the three diazines...

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Nucleic acid metabolism

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nitrogenous base. The bases found in nucleic acids are either purines or pyrimidines. In the more complex multicellular animals, they are both primarily produced...

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Nucleoside triphosphate

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and pyrimidine nucleotide synthesis and metabolism". The Arabidopsis Book. 1: e0018. doi:10.1199/tab.0018. PMC 3243375. PMID 22303196. "Pyrimidine Metabolism"...

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Gout

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nmol/L increase in 25(OH) D (P < 0.001). Gout is a disorder of purine metabolism, and occurs when its final metabolite, uric acid, crystallizes in the...

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Causes of autism

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hypothesizes that autoantibodies that target the brain or elements of brain metabolism may cause or exacerbate autism. It is related to the maternal infection[broken...

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Inborn errors of metabolism

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porphyria Disorders of purine or pyrimidine metabolism Lesch–Nyhan syndrome AMPD1 Deficiency (MADD) Disorders of steroid metabolism lipoid congenital adrenal...

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Orotic aciduria

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Balasubramaniam, S; Duley, JA; Christodoulou, J (Sep 2014). "Inborn errors of pyrimidine metabolism: clinical update and therapy". Journal of Inherited Metabolic Disease...

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Nucleotide

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The purine bases adenine and guanine and pyrimidine base cytosine occur in both DNA and RNA, while the pyrimidine bases thymine (in DNA) and uracil (in RNA)...

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Orotic acid

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Duley JA, Christodoulou J (September 2014). "Inborn errors of pyrimidine metabolism: clinical update and therapy". Journal of Inherited Metabolic Disease...

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Ribosylpyrimidine nucleosidase

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pyrimidine nucleoside hydrolase, RihB, YeiK, and nucleoside ribohydrolase. This enzyme participates in purine metabolism and pyrimidine metabolism. As...

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Adenosine deaminase deficiency

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Adenosine deaminase deficiency (ADA deficiency) is a metabolic disorder that causes immunodeficiency. It is caused by mutations in the ADA gene. It accounts...

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Nucleoside deoxyribosyltransferase

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II [purine(pyrimidine), and nucleoside:purine(pyrimidine) deoxyribosyltransferase]. This enzyme participates in pyrimidine metabolism. As of late 2007...

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Uric acid

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PMID 17494796. Angstadt, C. N. (4 December 1997). "Purine and Pyrimidine Metabolism: Purine Catabolism". NetBiochem. Proctor, P. (November 1970). "Similar...

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Purine metabolism

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Purine metabolism refers to the metabolic pathways to synthesize and break down purines that are present in many organisms. Purines are biologically synthesized...

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Hyperuricemia

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production include high levels of purine in the diet and increased purine metabolism. Causes of decreased excretion include kidney disease, certain drugs,...

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Metabolism

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classified as purines or pyrimidines. Nucleotides also act as coenzymes in metabolic-group-transfer reactions. Metabolism involves a vast array of chemical...

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Inner mitochondrial membrane

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Translocase of the inner membrane Glutamate aspartate transporter Pyrimidine metabolism Dihydroorotate dehydrogenase Thymidylate synthase (FAD) HtrA serine...

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De novo synthesis

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Stryer L (2007). Biochemistry. 6th Edition. WH Freeman and Company. New York. USA Purine and pyrimidine metabolism De novo synthesis of purine nucleotides...

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Exercise intolerance

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metabolism (including muscle GSDs), inborn errors of lipid metabolism (fatty acid metabolism disorder), inborn error of purine–pyrimidine metabolism (such...

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Carbamoyl phosphate synthetase

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(mitochondria, urea cycle) Carbamoyl phosphate synthetase II (cytosol, pyrimidine metabolism). Carbamoyl phosphate synthetase III (found in fish). Carbamoyl...

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Mitochondrial neurogastrointestinal encephalopathy syndrome

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Mitochondrial neurogastrointestinal encephalopathy syndrome (MNGIE) is a rare autosomal recessive mitochondrial disease. It has been previously referred...

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Dihydropyrimidinase

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peptidase, pyrimidine hydrase, and D-hydantoinase. This enzyme participates in 3 metabolic pathways: pyrimidine metabolism, beta-alanine metabolism, and pantothenate...

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Pyrimidine analogue

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Pyrimidine analogues are antimetabolites which mimic the structure of metabolic pyrimidines. Nucleobase analogues Fluorouracil (5FU), which inhibits thymidylate...

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Mercaptopurine

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1365-2036.2001.01102.x. PMID 11683683. Hansen, Barbara. "Purine and Pyrimidine Metabolism." USMLE STEP 1 Biochemistry and Medical Genetics Lecture Notes....

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