'de novo' pyrimidine nucleobase biosynthetic process
lactation
pyrimidine nucleobase biosynthetic process
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
7372
22247
Ensembl
ENSG00000114491
ENSMUSG00000022814
UniProt
P11172
P13439
RefSeq (mRNA)
NM_000373
NM_009471 NM_001348087
RefSeq (protein)
NP_000364
NP_033497 NP_001335016
Location (UCSC)
Chr 3: 124.73 – 124.75 Mb
Chr 16: 33.78 – 33.79 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
The enzyme Uridine monophosphate synthase (EC 4.1.1.23, UMPS) (orotate phosphoribosyl transferase and orotidine-5'-decarboxylase) catalyses the formation of uridine monophosphate (UMP), an energy-carrying molecule in many important biosynthetic pathways.[5] In humans, the gene that codes for this enzyme is located on the long arm of chromosome 3 (3q13).[6]
^ abcGRCh38: Ensembl release 89: ENSG00000114491 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000022814 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Qumsiyeh MB, Valentine MB, Suttle DP (Jul 1989). "Localization of the gene for uridine monophosphate synthase to human chromosome region 3q13 by in situ hybridization". Genomics. 5 (1): 160–2. doi:10.1016/0888-7543(89)90103-1. PMID 2767686.
and 26 Related for: Uridine monophosphate synthase information
The enzyme Uridinemonophosphatesynthase (EC 4.1.1.23, UMPS) (orotate phosphoribosyl transferase and orotidine-5'-decarboxylase) catalyses the formation...
synthase. Defective UMP synthase can result in orotic aciduria, a metabolic disorder. In a study, gerbils fed a combination of uridinemonophosphate,...
sequencing of the UMPS gene. Treatment is administration of uridinemonophosphate (UMP) or uridine triacetate (which is converted to UMP). These medications...
Retrieved 20 October 2014. Bailey, CJ (2009). "Orotic aciduria and uridinemonophosphatesynthase: a reappraisal". Journal of Inherited Metabolic Disease. 32:...
performed in aerobes by the ATP synthase during oxidative phosphorylation) AMP can be converted into inosine monophosphate by the enzyme myoadenylate deaminase...
decarboxylated by orotidine-5'-phosphate decarboxylase to form uridinemonophosphate (UMP). PRPP transferase catalyzes both the ribosylation and decarboxylation...
in UMP synthase is associated with hypochromic anemia. In mammals, this bifunctional enzyme UMPS converts orotic acid into uridinemonophosphate (UMP)...
utilized in both cell regulation and cell signaling as seen in adenosine-monophosphate (AMP). Furthermore, ribonucleotides can be converted to adenosine triphosphate...
5'-monophosphate, is a molecule formed in vivo from 5-fluorouracil and 5-fluorodeoxyuridine. FdUMP acts as a suicide inhibitor of thymidylate synthase (TS)...
AICAR + fTHF → FAICAR + THF The last step is catalyzed by Inosine monophosphatesynthase. FAICAR → IMP + H2O In eukaryotes the second, third, and fifth step...
ribose sugar to form the ribonucleoside uridine. When a phosphate attaches to uridine, uridine 5′-monophosphate is produced. Uracil undergoes amide-imidic...
can be interconverted to adenosine triphosphate (ATP) and adenosine monophosphate (AMP). ATP contains one more phosphate group than does ADP. AMP contains...
are thymine, cytosine and uracil (which is only found in RNA). Uridinemonophosphate biosynthesis involves an enzyme that is located in the mitochondrial...
UDP-galactosamine accumulation within cells, and uridine triphosphate (UTP), UDP, and uridinemonophosphate (UMP) decrease. The depletion of high-energy molecules...
derivative. Cytarabine-5´-monophosphate is deaminated by deoxycytidylate deaminase, leading to the inactive uridine-5´-monophosphate analog. Cytarabine-5´-triphosphate...
monosaccharides by glycosyltransferase from a reactive sugar-phosphate donor such as uridine diphosphate glucose (UDP-Glc) to an acceptor hydroxyl group on the growing...
thymidine, by the enzyme thymidylate synthase. The second route is sufficient to supply thymidine monophosphate for DNA repair. When a cell prepares to...
prostacyclin-stimulated rise in the levels of platelet adenosine 3',5'-cyclic monophosphate (cAMP) was stimulated by myricetin. Myricetin's preclinical immunomodulatory...
chemistries. Sutherland has demonstrated high-yielding routes to cytidine and uridine ribonucleotides from small 2 and 3 carbon fragments such as glycolaldehyde...
oxidation of dihydroorotate to orotate, which is part of the de novo uridine 5'-monophosphate (UMP) synthesis pathway. This oxidation is mediated by flavin mononucleotide...
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