A salvage pathway is a pathway in which a biological product is produced from intermediates in the degradative pathway of its own or a similar substance. The term often refers to nucleotide salvage in particular, in which nucleotides (purine and pyrimidine) are synthesized from intermediates in their degradative pathway.
Nucleotide salvage pathways are used to recover bases and nucleosides that are formed during degradation of RNA and DNA. This is important in some organs because some tissues cannot undergo de novo synthesis. The salvaged products can then be converted back into nucleotides. Salvage pathways are targets for drug development, one family being called antifolates.[1]
A number of other biologically-important substances, like methionine and nicotinate, have their own salvage pathways to recycle parts of the molecule.
^Cite error: The named reference CR was invoked but never defined (see the help page).
and 28 Related for: Nucleotide salvage information
or a similar substance. The term often refers to nucleotidesalvage in particular, in which nucleotides (purine and pyrimidine) are synthesized from intermediates...
needed] In vivo, nucleotides can be synthesized de novo or recycled through salvage pathways. The components used in de novo nucleotide synthesis are derived...
reaction and the resulting parts of the nucleotides or nucleobases can be salvaged to recreate new nucleotides. Both synthesis and degradation reactions...
bond. These enzymes are involved in repairing DNA and RNA sequences, nucleotidesalvage, and in the conversion of cGMP and cAMP to GMP and AMP, respectively...
Nucleotide bases (also nucleobases, nitrogenous bases) are nitrogen-containing biological compounds that form nucleosides, which, in turn, are components...
a dinucleotide because it consists of two nucleotides joined through their phosphate groups. One nucleotide contains an adenine nucleobase and the other...
I PRTase family and is involved in the nucleotidesalvage pathway, which provides an alternative to nucleotide biosynthesis de novo in humans and most...
transport chain. Nucleotides are synthesized through salvage or de novo synthesis. Nucleotidesalvage uses pieces of previously made nucleotides and re-synthesizes...
Hypoxanthine-guanine phosphoribosyltransferase converts hypoxanthine into IMP in nucleotidesalvage. Hypoxanthine is also a spontaneous deamination product of adenine...
Salvage enzymes are enzymes, nucleoside kinases, required during cell division to "salvage" nucleotides, present in body fluids, for the manufacture of...
sequence conservation suggests the crucial nature of ADA in the purine salvage pathway. Primarily, ADA in humans is involved in the development and maintenance...
host is unclear. However, B. mayonii has genes for purine salvage, a type of nucleotidesalvage, and metabolism, but its use of these genes is unknown....
phosphate, abbreviated NADP+ or, in older notation, TPN (triphosphopyridine nucleotide), is a cofactor used in anabolic reactions, such as the Calvin cycle and...
as terminally differentiated neurons, depend completely on purine nucleotidesalvage. Thus, use of mycophenolic acid leads to a relatively selective inhibition...
(or from food) can also be salvaged and reused in new nucleotides. The enzyme adenine phosphoribosyltransferase (APRT) salvages adenine. The enzyme hypoxanthine-guanine...
Nucleosides are glycosylamines that can be thought of as nucleotides without a phosphate group. A nucleoside consists simply of a nucleobase (also termed...
Be Synthesized de Novo or Recycled by Salvage Pathways. "Purine Synthesis : Synthesis of Purine RiboNucleotides". BiochemDen.com. 2016-03-16. Retrieved...
adenosine monophosphates and are involved predominantly in the salvage of preformed nucleotides and in signal transduction cascades involving purinergic receptors...
facilitate division and tend to rely on de novo synthesis rather than the nucleotidesalvage pathway. Several folate based inhibitors have been developed to inhibit...
phosphate. It is one enzyme of the nucleotidesalvage pathways. These pathways allow the cell to produce nucleotide monophosphates when the de novo synthesis...
as de novo synthesis of IMP or through salvage pathways of guanine (a purine) and any of the purine nucleotides and nucleosides. IMP is synthesized de...
Hence, unfused myeloma cells die, as they cannot produce nucleotides by the de novo or salvage pathway. Unfused B cells die as they have a short lifespan...
ribonucleotide is a nucleotide containing ribose as its pentose component. It is considered a molecular precursor of nucleic acids. Nucleotides are the basic...
extracts. Further work on nucleotide metabolism allowed him to identify nucleoside phosphorylase, a key enzyme in nucleotidesalvage pathways. The work was...
intermediate in the formation of purine nucleotides via inosine-5-monophosphate, as well as in pyrimidine nucleotide formation. Hence it is a building block...
higher in patients who are not receiving treatment. Purine metabolism Nucleotidesalvage Edvardsson, Vidar Orn; Sahota, Amrik; Palsson, Runolfur (September...
Global Information