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Tropicamide information


Tropicamide
Clinical data
Trade namesMydriacyl, others
AHFS/Drugs.comMonograph
License data
  • US DailyMed: Tropicamide
Pregnancy
category
  • C
Routes of
administration
Topical eye drops
ATC code
  • S01FA06 (WHO)
Legal status
Legal status
  • AU: S4 (Prescription only)[1]
  • UK: POM (Prescription only)[2]
  • US: ℞-only
Pharmacokinetic data
Protein binding45%
Identifiers
IUPAC name
  • (RS)-N-Ethyl-3-hydroxy-2-phenyl-N-(pyridin-4-ylmethyl)propanamide
CAS Number
  • 1508-75-4 checkY
PubChem CID
  • 5593
IUPHAR/BPS
  • 7319
DrugBank
  • DB00809 ☒N
ChemSpider
  • 5391 ☒N
UNII
  • N0A3Z5XTC6
KEGG
  • D00397 checkY
ChEMBL
  • ChEMBL1200604 ☒N
CompTox Dashboard (EPA)
  • DTXSID8045220 Edit this at Wikidata
ECHA InfoCard100.014.673 Edit this at Wikidata
Chemical and physical data
FormulaC17H20N2O2
Molar mass284.359 g·mol−1
3D model (JSmol)
  • Interactive image
SMILES
  • CCN(Cc1ccncc1)C(=O)C(CO)c1ccccc1
InChI
  • InChI=1S/C17H20N2O2/c1-2-19(12-14-8-10-18-11-9-14)17(21)16(13-20)15-6-4-3-5-7-15/h3-11,16,20H,2,12-13H2,1H3
  • Key:BGDKAVGWHJFAGW-UHFFFAOYSA-N
 ☒NcheckY (what is this?)  (verify)

Tropicamide, sold under the brand name Mydriacyl among others, is a medication used to dilate the pupil and help with examination of the eye.[3] Specifically it is used to help examine the back of the eye.[4] It is applied as eye drops.[3] Effects occur within 40 minutes and last for up to a day.[3]

Common side effects include blurry vision, increased intraocular pressure, and sensitivity to light.[3] Another rare but severe side effect is psychosis, particularly in children.[3] It is unclear if use during pregnancy is safe for the fetus.[5] Tropicamide is in the antimuscarinic part of the anticholinergic family of medications.[3] It works by making the muscles within the eye unable to respond to nerve signals.[3]

Tropicamide was approved for medical use in the United States in 1960.[3] It is on the World Health Organization's List of Essential Medicines.[6]

  1. ^ "Summary for ARTG Entry: 25356 Mydriacyl tropicamide 0.5% eye drops bottle". Therapeutic Goods Administration. Archived from the original on 5 June 2023. Retrieved 5 June 2023.
  2. ^ "Mydriacyl 1% eye drops, solution - Summary of Product Characteristics (SmPC)". Electronic Medicines Compendium. 12 February 2020. Archived from the original on 27 June 2022. Retrieved 29 July 2020.
  3. ^ a b c d e f g h "Tropicamide". Drugs.com. American Society of Health-System Pharmacists. Archived from the original on 28 December 2016. Retrieved 8 December 2016.
  4. ^ World Health Organization (2009). Stuart MC, Kouimtzi M, Hill SR (eds.). WHO Model Formulary 2008. World Health Organization. p. 314. hdl:10665/44053. ISBN 9789241547659.
  5. ^ "Tropicamide ophthalmic Use During Pregnancy". Drugs.com. Archived from the original on 28 December 2016. Retrieved 28 December 2016.
  6. ^ World Health Organization (2019). World Health Organization model list of essential medicines: 21st list 2019. Geneva: World Health Organization. hdl:10665/325771. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.

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Tropicamide

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Tropicamide, sold under the brand name Mydriacyl among others, is a medication used to dilate the pupil and help with examination of the eye. Specifically...

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Anticholinergic

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Solifenacin Tolterodine Tiotropium Tricyclic antidepressants Trihexyphenidyl Tropicamide Umeclidinium Antinicotinic agents Bupropion – Ganglion blocker Dextromethorphan...

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Eye drop

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taken recreationally, tropicamide acts as a deliriant. When injected intravenously, as is most often the case, the tropicamide may cause problems such...

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Mydriasis

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mydriatic is an agent that induces dilation of the pupil. Drugs such as tropicamide are used in medicine to permit examination of the retina and other deep...

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Atropine

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14 days, so it is generally used as a therapeutic mydriatic, whereas tropicamide (a shorter-acting cholinergic antagonist) or phenylephrine (an α-adrenergic...

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Phenylephrine

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of the retina. It is often used in combination with tropicamide as a synergist when tropicamide alone is not sufficient. Narrow-angle glaucoma is a contraindication...

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Dilated fundus examination

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adults) and tropicamide (0.5% or 1%). While phenylephrine stimulates receptors that contract the dilator muscle of the pupil, tropicamide blocks stimulation...

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Cycloplegia

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antagonists such as atropine, cyclopentolate, homatropine, scopolamine and tropicamide. They are indicated for use in cycloplegic refraction (to paralyze the...

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Cyclopentolate

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alternative to atropine, another cycloplegic agent which lasts much longer. Tropicamide is an even shorter-lasting cycloplegic than cyclopentolate, but is less...

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Ophthalmoscopy

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to dilate the pupil by application of a mydriatic agent, for instance tropicamide, or simply reducing the brightness of the ophthalmoscope, which may slightly...

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Anisocoria

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pharmacological agents which may affect the pupils include pilocarpine, cocaine, tropicamide, MDMA, dextromethorphan, and ergolines. Alkaloids present in plants of...

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Polycoria

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placed under retrobulbar anesthesia with the pupils being dilated with 1% tropicamide. Hypertonic saline solution used as eye drops may be used to reduce the...

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WHO Model List of Essential Medicines

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Complementary: Methotrexateα Benzyl benzoate Permethrin Fluorescein Tropicamide Amidotrizoate Barium sulfate Iohexol Complementary: Barium sulfateα Meglumine...

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Dimenhydrinate

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Trihexyphenidyl Trimebutine Tripitamine (tripitramine) Tropacine Tropatepine Tropicamide Trospium chloride Typical antipsychotics (e.g., chlorpromazine, chlorprothixene...

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Deliriant

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Arachne into a spider. Anticholinergics Flying ointment Scopolamine Tropicamide Psychedelic drug Dissociative Hallucinogen Psychoactive drug Duncan,...

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Pupil

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caused by mydriatic substances such as an eye drop solution containing tropicamide. A condition called bene dilitatism occurs when the optic nerves are...

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Scopolamine

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Trihexyphenidyl Trimebutine Tripitamine (tripitramine) Tropacine Tropatepine Tropicamide Trospium chloride Typical antipsychotics (e.g., chlorpromazine, chlorprothixene...

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Datura

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Trihexyphenidyl Trimebutine Tripitamine (tripitramine) Tropacine Tropatepine Tropicamide Trospium chloride Typical antipsychotics (e.g., chlorpromazine, chlorprothixene...

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Promethazine

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Trihexyphenidyl Trimebutine Tripitamine (tripitramine) Tropacine Tropatepine Tropicamide Trospium chloride Typical antipsychotics (e.g., chlorpromazine, chlorprothixene...

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Chlorphenamine

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Trihexyphenidyl Trimebutine Tripitamine (tripitramine) Tropacine Tropatepine Tropicamide Trospium chloride Typical antipsychotics (e.g., chlorpromazine, chlorprothixene...

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Desomorphine

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material, as well as co-administration with pharmaceuticals such as tropicamide and tianeptine, are also cited as possible contributors to the high toxicity...

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Ketamine

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Trihexyphenidyl Trimebutine Tripitamine (tripitramine) Tropacine Tropatepine Tropicamide Trospium chloride Typical antipsychotics (e.g., chlorpromazine, chlorprothixene...

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Eye color

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classification of iris colour and its correlation with response to 1% tropicamide". Ophthalmic Physiol Opt. 18 (2): 103–10. doi:10.1016/S0275-5408(97)00070-7...

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Doxylamine

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Trihexyphenidyl Trimebutine Tripitamine (tripitramine) Tropacine Tropatepine Tropicamide Trospium chloride Typical antipsychotics (e.g., chlorpromazine, chlorprothixene...

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Meclizine

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Trihexyphenidyl Trimebutine Tripitamine (tripitramine) Tropacine Tropatepine Tropicamide Trospium chloride Typical antipsychotics (e.g., chlorpromazine, chlorprothixene...

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Choline

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Trihexyphenidyl Trimebutine Tripitamine (tripitramine) Tropacine Tropatepine Tropicamide Trospium chloride Typical antipsychotics (e.g., chlorpromazine, chlorprothixene...

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