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Trihexyphenidyl information


Trihexyphenidyl
Clinical data
Trade namesArtane, Parkin, Pacitane, Hexymer
AHFS/Drugs.comMonograph
MedlinePlusa682160
License data
  • US DailyMed: Trihexyphenidyl
Pregnancy
category
  • AU: B1
Routes of
administration
Oral, as tablet or elixir
ATC code
  • N04AA01 (WHO)
Legal status
Legal status
  • BR: Class B1 (Psychoactive drugs)[1]
  • US: ℞-only
Pharmacokinetic data
Elimination half-life3.3-4.1 hours
Identifiers
IUPAC name
  • (RS)-1-Cyclohexyl-1-phenyl-3-(1-piperidyl)propan-1-ol
CAS Number
  • 144-11-6 checkY
PubChem CID
  • 5572
IUPHAR/BPS
  • 7315
DrugBank
  • DB00376 checkY
ChemSpider
  • 5371 checkY
UNII
  • 6RC5V8B7PO
KEGG
  • D08638 checkY
ChEMBL
  • ChEMBL1490 checkY
CompTox Dashboard (EPA)
  • DTXSID4023705 Edit this at Wikidata
ECHA InfoCard100.005.105 Edit this at Wikidata
Chemical and physical data
FormulaC20H31NO
Molar mass301.474 g·mol−1
3D model (JSmol)
  • Interactive image
SMILES
  • OC(c1ccccc1)(CCN2CCCCC2)C3CCCCC3
InChI
  • InChI=1S/C20H31NO/c22-20(18-10-4-1-5-11-18,19-12-6-2-7-13-19)14-17-21-15-8-3-9-16-21/h1,4-5,10-11,19,22H,2-3,6-9,12-17H2 checkY
  • Key:HWHLPVGTWGOCJO-UHFFFAOYSA-N checkY
  (verify)

Trihexyphenidyl (THP, benzhexol, trihex, marketed as Artane and others) is an antispasmodic drug used to treat stiffness, tremors, spasms, and poor muscle control. It is an agent of the antimuscarinic class and is often used in management of Parkinson's disease. It was approved by the FDA for the treatment of Parkinson's in the US in 2003.[2][3]

It is on the World Health Organization's List of Essential Medicines.[4]

  1. ^ Anvisa (2023-03-31). "RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). Diário Oficial da União (published 2023-04-04). Archived from the original on 2023-08-03. Retrieved 2023-08-16.
  2. ^ "TGA eBS - Product and Consumer Medicine Information Licence". www.ebs.tga.gov.au. Retrieved 2020-08-20.
  3. ^ FDA (2003-05-25). "New Drug Application Approval Notice" (PDF). Retrieved 2020-08-20.
  4. ^ World Health Organization (2021). World Health Organization model list of essential medicines: 22nd list (2021). Geneva: World Health Organization. hdl:10665/345533. WHO/MHP/HPS/EML/2021.02.

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