Hyoscyamine (also known as daturine or duboisine) is a naturally occurring tropane alkaloid and plant toxin. It is a secondary metabolite found in certain plants of the family Solanaceae, including henbane, mandrake, angel's trumpets, jimsonweed, the sorcerers' tree, and Atropa belladonna (deadly nightshade). It is the levorotary isomer of atropine (third of the three major nightshade alkaloids) and thus sometimes known as levo-atropine.[1]
In 2021, it was the 272nd most commonly prescribed medication in the United States, with more than 900,000 prescriptions.[2][3]
^Ushimaru R, Ruszczycky MW, Liu HW (January 2019). "Changes in Regioselectivity of H Atom Abstraction during the Hydroxylation and Cyclization Reactions Catalyzed by Hyoscyamine 6β-Hydroxylase". Journal of the American Chemical Society. 141 (2): 1062–1066. doi:10.1021/jacs.8b11585. PMC 6488026. PMID 30545219.
^"The Top 300 of 2021". ClinCalc. Archived from the original on 15 January 2024. Retrieved 14 January 2024.
^"Hyoscyamine - Drug Usage Statistics". ClinCalc. Retrieved 14 January 2024.
Hyoscyamine (also known as daturine or duboisine) is a naturally occurring tropane alkaloid and plant toxin. It is a secondary metabolite found in certain...
an enantiomeric mixture of d-hyoscyamine and l-hyoscyamine, with most of its physiological effects due to l-hyoscyamine. Its pharmacological effects are...
drugs and deliriants: Atropine, racemic hyoscyamine, from the deadly nightshade (Atropa belladonna) Hyoscyamine, the levo-isomer of atropine, from henbane...
pharmaceutical. Medicines of different classes include atropine, scopolamine, and hyoscyamine (all from nightshade), the traditional medicine berberine (from plants...
technique has also been used to produce the alkaloids scopolamine and hyoscyamine. Plant in flower. Single flower (interior). Scopoliae Rhizoma (root of...
containing tropane alkaloids. These toxins include atropine, scopolamine, and hyoscyamine, which cause delirium and hallucinations, and are also used as pharmaceutical...
and the genes that produce them. Hyoscyamine 6-β-hydroxylase, for example, catalyses the hydroxylation of hyoscyamine that leads to the production of scopolamine...
deliriant hallucinogenic tropane alkaloids (atropine, scopolamine, and hyoscyamine) which cause delirium and hallucinations, and the shape of their roots...
as Cyp80F1 oxidizes and rearranges littorine to hyoscyamine aldehyde. In the final step, hyoscyamine undergoes epoxidation catalyzed by 6beta-hydroxyhyoscyamine...
a laboratory reagent used in the chemical synthesis of atropine and hyoscyamine. Tropic acid is a chiral substance, existing as either a racemic mixture...
and the smoke inhaled. The primary alkaloid present in the mixture was hyoscyamine, and when the powder was ingested rather than burned, could be used to...
procedures. Classic antisialagogues include: atropine, opioids, alkalis, hyoscyamine, scopolamine, tobacco in excess, most cannabinoids, all nauseous or insipid...
and mephedrone. Anticholinergics such as diphenhydramine, atropine, hyoscyamine, and scopolamine antagonize the muscarinic acetylcholine receptors in...
native traditions. The alkaloids present include atropine, noratropine, hyoscyamine, and tropine with about 0.15% overall content in the leaves. In all ten...
to vasodilation. Important muscarinic antagonists include atropine, hyoscyamine, hyoscine butylbromide and hydrobromide, ipratropium, tropicamide, cyclopentolate...
tolterodine, certain medications for stomach problems, such as dicyclomine and hyoscyamine, and certain medications for travel sickness, such as scopolamine. Chemically...
belladonna. It is closely related in chemical structure to atropine, hyoscyamine, and scopolamine, which all share a common biosynthetic pathway. Catuabine...
spasms of the stomach, intestine or urinary bladder. Both dicyclomine and hyoscyamine are antispasmodic due to their anticholinergic action.[medical citation...
the same substance could be used in the production of scopolamine and hyoscyamine, which are used in eye surgery, and a multi-million dollar industry was...
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