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Toluidine information


There are three isomers of toluidine, which are organic compounds. These isomers are o-toluidine, m-toluidine, and p-toluidine, with the prefixed letter abbreviating, respectively, ortho; meta; and para. All three are aryl amines whose chemical structures are similar to aniline except that a methyl group is substituted onto the benzene ring. The difference between these three isomers is the position where the methyl group (–CH3) is bonded to the ring relative to the amino functional group (–NH2); see illustration of the chemical structures below.[1]

Toluidine isomers
Methyl position ortho meta para
Common name o-toluidine m-toluidine p-toluidine
Other names o-methylaniline m-methylaniline p-methylaniline
Chemical name 2-methylaniline 3-methylaniline 4-methylaniline
Chemical formula C7H9N
Molecular mass 107.17 g/mol
Glass transition temperature 189 K[2] 187 K[3] Glass not formed[2]
Melting point −23 °C −30 °C 43 °C
Boiling point 199–200 °C 203–204 °C 200 °C
Density 1.00 g/cm3 0.98 g/cm3 1.05 g/cm3
Magnetic susceptibility 76.0 × 10−6 cm3/mol 74.6 × 10−6 cm3/mol 72.1 × 10−6 cm3/mol
CAS number [95-53-4] [108-44-1] [106-49-0]
SMILES Cc1ccccc1N Cc1cccc(N)c1 Cc1ccc(N)cc1
Disclaimer and references

The chemical properties of the toluidines are quite similar to those of aniline, and toluidines have properties in common with other aromatic amines. Due to the amino group bonded to the aromatic ring, the toluidines are weakly basic. The toluidines are poorly soluble in pure water but dissolve well in acidic water due to formation of ammonium salts, as usual for organic amines. ortho- and meta-toluidines are viscous liquids, but para-toluidine is a flaky solid. This difference is related to the fact that the p-toluidine molecules are more symmetrical. p-Toluidine can be obtained from reduction of p-nitrotoluene. p-Toluidine reacts with formaldehyde to form Tröger's base.

  1. ^ Bowers, Joseph S. "Toluidines". Ullmann's Encyclopedia of Industrial Chemistry. Weinheim: Wiley-VCH. doi:10.1002/14356007.a27_159. ISBN 978-3527306732.
  2. ^ a b Pratesi, G.; Bartolini, P.; Senatra, D.; Ricci, M.; Righini, R.; Barocchi, F.; Torre, R. (2003). "Experimental studies of the ortho-toluidine glass transition". Physical Review E. 67 (2). doi:10.1103/PhysRevE.67.021505.
  3. ^ Alba-Simionesco, C.; Fan, J.; Angell, C. A. (1999). "Thermodynamic aspects of the glass transition phenomenon. II. Molecular liquids with variable interactions". The Journal of Chemical Physics. 110 (11): 5262. doi:10.1063/1.478800.

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substances present in these tissues, called chromotropes. For example, toluidine blue becomes dark blue (with a colour range from blue-red dependent on...

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organism in sputum or bronchoalveolar lavage (lung rinse). Staining with toluidine blue, silver stain, periodic acid-Schiff stain, or an immunofluorescence...

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1"-Phosphinothioylidynetrisaziridine) Treosulfan Trichloroethylene o-Toluidine Vinyl chloride Ionizing radiation (all types) Neutron radiation Phosphorus-32...

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derived from the Greek orthos (correct, upright), and chromatic (color). Toluidine blue is an example of a partially orthochromatic dye, as it stains nucleic...

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