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Toluidine blue information


Toluidine blue
Names
IUPAC name
(7-amino-8-methylphenothiazin-3-ylidene)-dimethylammonium chloride
Other names
Toluidine blue O
Identifiers
CAS Number
  • 92-31-9 ☒N
3D model (JSmol)
  • Interactive image
ChEBI
  • CHEBI:87647 ☒N
ChEMBL
  • ChEMBL1790006 ☒N
ChemSpider
  • 11239098 checkY
ECHA InfoCard 100.001.952 Edit this at Wikidata
MeSH Tolonium+chloride
PubChem CID
  • 7084
UNII
  • 15XUH0X66N ☒N
CompTox Dashboard (EPA)
  • DTXSID9048728 Edit this at Wikidata
InChI
  • InChI=1S/C15H16N3S.ClH/c1-9-6-13-15(8-11(9)16)19-14-7-10(18(2)3)4-5-12(14)17-13;/h4-8H,16H2,1-3H3;1H/q+1;/p-1 checkY
    Key: HNONEKILPDHFOL-UHFFFAOYSA-M checkY
  • InChI=1/C15H16N3S.ClH/c1-9-6-13-15(8-11(9)16)19-14-7-10(18(2)3)4-5-12(14)17-13;/h4-8H,16H2,1-3H3;1H/q+1;/p-1
    Key: HNONEKILPDHFOL-REWHXWOFAY
SMILES
  • [Cl-].CN(C)c1ccc2nc3cc(C)c(N)cc3[s+]c2c1
Properties
Chemical formula
C15H16N3S+
Molar mass 270.374 g/mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references

Toluidine blue, also known as TBO or tolonium chloride (INN) is a blue cationic (basic) dye used in histology (as the toluidine blue stain) and sometimes clinically.

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Toluidine blue

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Toluidine blue, also known as TBO or tolonium chloride (INN) is a blue cationic (basic) dye used in histology (as the toluidine blue stain) and sometimes...

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Toluidine

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There are three isomers of toluidine, which are organic compounds. These isomers are o-toluidine, m-toluidine, and p-toluidine, with the prefixed letter...

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Alcian blue stain

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(e.g. toluidine blue, methylene blue and azure A etc.), which are metachromatic due to switching from monomeric to stacked aggregates, Alcian blue is apparently...

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Metachromasia

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tissues, called chromotropes. For example, toluidine blue becomes dark blue (with a colour range from blue-red dependent on glycosaminoglycan content)...

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Staining

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complementing stains used alongside Bismark brown are Hematoxylin and Toluidine blue which provide better contrast within the histology sample. Carmine is...

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Pneumocystis pneumonia

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organism in sputum or bronchoalveolar lavage (lung rinse). Staining with toluidine blue, silver stain, periodic acid-Schiff stain, or an immunofluorescence...

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Volutin granules

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polymetaphosphate. They appear reddish when stained with polychrome methylene blue or toluidine blue (metachromasia). Special staining techniques such as Albert's or...

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Orthochromasia

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chromatic (color). Toluidine blue is an example of a partially orthochromatic dye, as it stains nucleic acids by its orthochromatic color (blue), but stains...

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Mohs surgery

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staining with hematoxylin and eosin (H&E) or other stains (Including Toluidine Blue) Interpretation of microscope slides (Pathology) Possible reconstruction...

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Leukoplakia

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from areas of dysplasia or carcinoma under blue light or by initially staining of the mucosa with toluidine blue or dilute acetic acid and examination under...

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MicroRNA biosensors

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biosensors utilizing the small molecule cationic dye toluidine blue to detect miRNA-21. Toluidine blue acts as a miRNA intercalative label through electrostatic...

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Lipofuscin

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Micrograph showing a cluster of lipofuscin particles (arrow) in a nerve cell of the brain; toluidine blue stain; scale bar = 10 microns (0.01 millimeters)...

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Peripheral neuropathy

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Micrograph showing a vasculitic peripheral neuropathy; plastic embedded; Toluidine blue stain Specialty Neurology Symptoms Shooting pain, numbness, tingling...

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Mast cell

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could contribute to brain inflammation and neurodevelopmental problems. Toluidine blue: one of the most common stains for acid mucopolysaccharides and glycoaminoglycans...

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Antimicrobial photodynamic therapy

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of morbidity and mortality. Photosensitizers such as methylene blue and toluidine blue have been incorporated into silicone, the main polymer used in...

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Trypan blue

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exclusion method. Trypan blue is derived from toluidine, that is, any of several isomeric bases, C14H16N2, derived from toluene. Trypan blue is so-called because...

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Flexplay

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methylene blue, prussian blue, brilliant cresyl blue, Toluidine Blue O, Basic Blue 3, Methylene green, Taylor's blue, Janus Green B, Meldola's Blue, Thionin...

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Foveolar cell

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correctly the cells stain strongly with special techniques like PAS or toluidine blue, the last representing the anionic nature of foveolar cell secretions...

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Sandy Ford

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Pneumocystis jirovecii cysts from bronchoalveolar lavage, stained with Toluidine blue O stain...

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Focal segmental glomerulosclerosis

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C3 trapping in areas of collapse/sclerosis. (F) Semi-fine stained in Toluidine Blue (63×) with collapse of the entire glomerular tuft and hyperplasia of...

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Chromoendoscopy

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with methylene blue staining. Also, methylene blue has been used to identify dysplasia in patients with ulcerative colitis. Toluidine blue stains nuclei...

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Neuropathology

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Micrograph of a vasculitic neuropathy. Plastic embedded. Toluidine blue stain....

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Oral cancer

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routine examinations. There are a variety of screening devices such as toluidine blue, brush biopsy, or fluorescence imaging, however, there is no evidence...

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Telocyte

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on toluidine blue stained semithin section (~1 μm thick ultramicrotome) Figure 14. Electron micrographs illustrates the relationships of TC (blue) with...

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Bacterial cell structure

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metachromatic effect; they appear red or blue when stained with the blue dyes methylene blue or toluidine blue. Gas vacuoles are membrane-bound, spindle-shaped...

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Elastic fiber

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elastic stain in histological sections. The permanganate-bisulfite-toluidine blue reaction is a highly selective and sensitive method for demonstrating...

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List of dyes

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yellow Clayton yellow Direct yellow 9 19540 azo 1829-00-1 Toluidine blue Tolonium chloride Basic blue 17 52040 thiazin 92-31-9 Tropaeolin O Chrysoine resorcinol...

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Transmission electron microscopy

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cut from the block face. The thick sections are crudely stained with toluidine blue and examined for specimen and block orientation before thin sectioning...

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