A nontreponemal test (NTT) is a blood test for diagnosis of infection with syphilis. Nontreponemal tests are an indirect method in that they detect biomarkers that are released during cellular damage that occurs from the syphilis spirochete. In contrast, treponemal tests look for antibodies that are a direct result of the infection thus, anti-treponeme IgG, IgM and to a lesser degree IgA. Nontreponemal tests are screening tests, very rapid and relatively simple, but need to be confirmed by treponemal tests.[1] Centers for Disease Control and Prevention (CDC)-approved standard tests include the VDRL test (a slide test), the rapid plasma reagin (RPR) test (a card test), the unheated serum reagin (USR) test, and the toluidine red unheated serum test (TRUST).[2] These have mostly replaced the first nontreponemal test, the Wassermann test.[citation needed]
^Ratnam, S (2005). "The laboratory diagnosis of syphilis". Canadian Journal of Infectious Diseases & Medical Microbiology. 16 (1): 45–51. doi:10.1155/2005/597580. PMC 2095002. PMID 18159528.
^Larsen SA, Pope V, Johnson RE, Kennedy EJ Jr (1998). A Aanual of Tests for Syphilis (9th ed.). Washington, DC: American Public Health Association. ISBN 978-0875532349.
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A nontreponemaltest (NTT) is a blood testfor diagnosis of infection with syphilis. Nontreponemaltests are an indirect method in that they detect biomarkers...
infection by syphilis or related non-venereal treponematoses. It is one of several nontreponemaltestsforsyphilis (along with the Wassermann test and the...
between the stages of the disease. Blood tests are divided into nontreponemal and treponemal tests. Nontreponemaltests are used initially and include venereal...
Public Health Service.[citation needed] The VDRL is a nontreponemal serological screening forsyphilis that is also used to assess response to therapy, to...
the first blood testforsyphilis and the first in the nontreponemaltest (NTT) category. Newer NTTs, such as the RPR and VDRL tests, have mostly replaced...
determining need for treatment. The treatment success is measured with a fourfold drop in the nontreponemal antibody test. In early-stage syphilis drop should...
Meningeal syphilis (as known as syphilitic aseptic meningitis or meningeal neurosyphilis) is a chronic form of syphilis infection that affects the central...
pinta (T. carateum), and syphilis (T. p. pallidum). Yaws is often diagnosed by the appearance of the lesions. Blood antibody tests may be useful, but cannot...
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