Confocal image of a spinal motor neuron showing stained lipofuscin granules in blue and yellowMicrograph showing a cluster of lipofuscin particles (arrow) in a nerve cell of the brain; toluidine blue stain; scale bar = 10 microns (0.01 millimeters)
Lipofuscin is the name given to fine yellow-brown pigment granules composed of lipid-containing residues of lysosomal digestion.[1][2] It is considered to be one of the aging or "wear-and-tear" pigments, found in the liver, kidney, heart muscle, retina, adrenals, nerve cells, and ganglion cells.[3]
^Alberts, Daniel Albert (2012). Dorland's illustrated medical dictionary (32nd ed.). Philadelphia, PA: Saunders/Elsevier. p. 1062. ISBN 978-1-4160-6257-8.
^"Medical Definition of LIPOFUSCIN". www.merriam-webster.com.
^Young B, Lowe JS, Stevens A, Heath JW. Wheater's Functional Histology: A Text and Atlas. 6th ed. Elsevier
Lipofuscin is the name given to fine yellow-brown pigment granules composed of lipid-containing residues of lysosomal digestion. It is considered to be...
storage diseases that result from excessive accumulation of lipopigments (lipofuscin) in the body's tissues. These lipopigments are made up of fats and proteins...
may have no significant correlation with disease. The brown pigment is lipofuscin in macrophages, not melanin.[citation needed] It is most commonly associated...
cells in the spot and release of lipofuscin bodies. The aggregating cells would form a capsule, and the dense lipofuscin bodies make the protruding spot...
exocytosis (this generally only occurs in macrophages), or they become lipofuscin granules that remain in the cytosol indefinitely. Longer-living cells...
aging pigment lipofuscin can be broken down with the help of melanin and drugs through a newly discovered mechanism. The pigment lipofuscin plays a central...
Histological sections appear yellowish-brown due to the presence of lipofuscin pigments. Olfactory mucosal cell types include bipolar neurons, supporting...
use β-Cyclodextrin for the prevention of atherosclerosis, age-related lipofuscin accumulation and obesity encounter an obstacle in the form of damage to...
by the secretion of colored sweat. It is caused by the deposition of lipofuscin in the sweat glands. Cases of red, blue, green, yellow, pink, and black...
and byproducts damage the retinal cells, fluorescent granules called lipofuscin in the retinal pigmented epithelium of the retina appear, reflecting such...
neuron with Nissl bodies and lipofuscin. The pink structures are Nissl bodies and the blue and yellow structures are the lipofuscin granules. In chromatolysis...
pigmented by intracellular deposits (mostly around the cell nucleus) of lipofuscin, a type of lipochrome granule. It has no known effect on function, and...
cells with significant hemosiderin deposition next to a hepatocyte with lipofuscin pigment. H&E stain. Prussian blue staining, highlighting the hemosiderin...
quantities of cytoplasm and lipid droplets, and sometimes display brown lipofuscin pigment. The adrenal medulla is at the centre of each adrenal gland, and...
mitochondria are also prominent within the cytoplasm. Reinke crystals have lipofuscin pigment and rod-shaped crystal-like structures 3 to 20 micrometres in...
large amounts of rough endoplasmic reticulum and free ribosomes. Brown lipofuscin granules are also observed (with increasing age) together with irregular...
Kupffer cells with significant hemosiderin deposition (shown next to a hepatocyte with lipofuscin pigment, which is a common normal finding). H&E stain....
humans, yellowish specks or patches are thought to be due to the pigment lipofuscin, also known as lipochrome. Many animals such as canines, domestic cats...
Lipopigments and Lysosomal Residual Bodies in Metachromatic Leukodystrophy". Lipofuscin and Ceroid Pigments. Advances in Experimental Medicine and Biology. Vol...
brownish-black pigment that is byproduct of synthesis of catecholamines), and lipofuscin (a yellowish-brown pigment), both of which accumulate with age. Other...
Maistrovich, Frank; et al. (2008). "Fluorescence-based method, exploiting lipofuscin, for real-time detection of central nervous system tissues on bovine carcasses"...
damages proteins. Damaged proteins and lipids accumulate in lysosomes as lipofuscin. Chemical damage to structural proteins can lead to loss of function;...
Kupffer cells with significant hemosiderin deposition (shown next to a hepatocyte with lipofuscin pigment, which is a common normal finding). H&E stain....
lipofuscin can be broken down with the help of melanin and drugs through a newly discovered mechanism (chemical excitation). The pigment lipofuscin plays...
to lipofuscin. Microscopic examination of liver tissue in patients with critical green inclusions has demonstrated prominent deposition of lipofuscin, suggesting...
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