Chemical compound
Tofogliflozin monohydrate Other names CSG452 ATC code Legal status
(1S ,3'R ,4'S ,5'S ,6'R )-6-(4-Ethylbenzyl)-6'-(hydroxymethyl)-3',4',5',6'-tetrahydro-3H -spiro[2-benzofuran-1,2'-pyran]-3',4',5'-triol hydrate (1:1)
CAS Number 1201913-82-7 903565-83-3 (anhydrous)PubChem CID ChemSpider UNII KEGG ChEMBL CompTox Dashboard (EPA ) DTXSID70152722 Formula C 22 H 28 O 7 Molar mass 404.459 g·mol−1 3D model (JSmol)
CCc1ccc(cc1)Cc2ccc3c(c2)[C@]4([C@@H]([C@H]([C@@H]([C@H](O4)CO)O)O)O)OC3.O
InChI=1S/C22H26O6.H2O/c1-2-13-3-5-14(6-4-13)9-15-7-8-16-12-27-22(17(16)10-15)21(26)20(25)19(24)18(11-23)28-22;/h3-8,10,18-21,23-26H,2,9,11-12H2,1H3;1H2/t18-,19-,20+,21-,22+;/m1./s1
Key:ZXOCGDDVNPDRIW-NHFZGCSJSA-N
Tofogliflozin (INN,[1] : 88 USAN, codenamed CSG452 ) is an experimental drug for the treatment of diabetes mellitus and is being developed by Chugai Pharma in collaboration with Kowa and Sanofi.[2] It is an inhibitor of subtype 2 sodium-glucose transport protein (SGLT2), which is responsible for at least 90% of the glucose reabsorption in the kidney. As of September 2012[update] , the drug is in Phase III clinical trials.[3] [4] [needs update ]
^ "International Nonproprietary Names for Pharmaceutical Substances (INN). Recommended International Nonproprietary Names: List 65" (PDF) . World Health Organization. Retrieved 15 November 2016 .
^ Chugai Pharmaceutical: Development Pipeline
^ Nagata T, Fukazawa M, Honda K, Yata T, Kawai M, Yamane M, et al. (February 2013). "Selective SGLT2 inhibition by tofogliflozin reduces renal glucose reabsorption under hyperglycemic but not under hypo- or euglycemic conditions in rats". American Journal of Physiology. Endocrinology and Metabolism . 304 (4): E414-23. doi:10.1152/ajpendo.00545.2012. PMID 23249697.
^ Ohtake Y, Sato T, Kobayashi T, Nishimoto M, Taka N, Takano K, et al. (September 2012). "Discovery of tofogliflozin, a novel C-arylglucoside with an O-spiroketal ring system, as a highly selective sodium glucose cotransporter 2 (SGLT2) inhibitor for the treatment of type 2 diabetes". Journal of Medicinal Chemistry . 55 (17): 7828–40. doi:10.1021/jm300884k. PMID 22889351.
Last Update: 2023-12-01T21:23:52Z
Tofogliflozin (INN,: 88 USAN, codenamed CSG452) is an experimental drug for the treatment of diabetes mellitus and is being developed by Chugai Pharma...
Word Count : 287
Last Update: 2024-06-17T22:15:09Z
Jardiance by Boehringer Ingelheim. Of the gliflozins, empagliflozin and tofogliflozin have the highest specificity for SGLT2 inhibition. This oral medicine...
Word Count : 4561
Last Update: 2024-03-22T03:35:15Z
Ertugliflozin Ipragliflozin Luseogliflozin Remogliflozin§ Sergliflozin§ Sotagliflozin Tofogliflozin † Velagliflozin Other Benfluorex‡ Bromocriptine Imeglimin...
Word Count : 262
Last Update: 2024-06-23T02:52:00Z
Ertugliflozin Ipragliflozin Luseogliflozin Remogliflozin§ Sergliflozin§ Sotagliflozin Tofogliflozin † Velagliflozin Other Benfluorex‡ Bromocriptine Imeglimin...
Word Count : 5418
Last Update: 2024-05-15T08:30:26Z
acid, thereby blocking post-synaptic transmission of nerve impulses Tofogliflozin is an inhibitor of human sodium glucose cotransporter 2 (hSGLT2) and...
Word Count : 528
Last Update: 2024-06-14T13:53:29Z
Ertugliflozin Ipragliflozin Luseogliflozin Remogliflozin§ Sergliflozin§ Sotagliflozin Tofogliflozin † Velagliflozin Other Benfluorex‡ Bromocriptine Imeglimin...
Word Count : 184
Last Update: 2024-05-19T21:56:02Z
Ertugliflozin Ipragliflozin Luseogliflozin Remogliflozin§ Sergliflozin§ Sotagliflozin Tofogliflozin † Velagliflozin Other Benfluorex‡ Bromocriptine Imeglimin...
Word Count : 3481
Last Update: 2024-04-11T15:05:59Z
Ertugliflozin Ipragliflozin Luseogliflozin Remogliflozin§ Sergliflozin§ Sotagliflozin Tofogliflozin † Velagliflozin Other Benfluorex‡ Bromocriptine Imeglimin...
Word Count : 1622
Last Update: 2024-06-15T07:27:28Z
Ertugliflozin Ipragliflozin Luseogliflozin Remogliflozin§ Sergliflozin§ Sotagliflozin Tofogliflozin † Velagliflozin Other Benfluorex‡ Bromocriptine Imeglimin...
Word Count : 193
Last Update: 2024-04-07T06:23:31Z
Ertugliflozin Ipragliflozin Luseogliflozin Remogliflozin§ Sergliflozin§ Sotagliflozin Tofogliflozin † Velagliflozin Other Benfluorex‡ Bromocriptine Imeglimin...
Word Count : 1512
Last Update: 2024-06-19T18:14:48Z
Ertugliflozin Ipragliflozin Luseogliflozin Remogliflozin§ Sergliflozin§ Sotagliflozin Tofogliflozin † Velagliflozin Other Benfluorex‡ Bromocriptine Imeglimin...
Word Count : 4939
Last Update: 2024-03-24T06:24:34Z
Ertugliflozin Ipragliflozin Luseogliflozin Remogliflozin§ Sergliflozin§ Sotagliflozin Tofogliflozin † Velagliflozin Other Benfluorex‡ Bromocriptine Imeglimin...
Word Count : 1575
Last Update: 2023-12-20T19:33:54Z
Ertugliflozin Ipragliflozin Luseogliflozin Remogliflozin§ Sergliflozin§ Sotagliflozin Tofogliflozin † Velagliflozin Other Benfluorex‡ Bromocriptine Imeglimin...
Word Count : 781
Last Update: 2024-05-08T15:03:31Z
Ertugliflozin Ipragliflozin Luseogliflozin Remogliflozin§ Sergliflozin§ Sotagliflozin Tofogliflozin † Velagliflozin Other Benfluorex‡ Bromocriptine Imeglimin...
Word Count : 2518
Last Update: 2024-06-10T05:35:25Z
Ertugliflozin Ipragliflozin Luseogliflozin Remogliflozin§ Sergliflozin§ Sotagliflozin Tofogliflozin † Velagliflozin Other Benfluorex‡ Bromocriptine Imeglimin...
Word Count : 14257
Last Update: 2023-12-20T19:33:15Z
Ertugliflozin Ipragliflozin Luseogliflozin Remogliflozin§ Sergliflozin§ Sotagliflozin Tofogliflozin † Velagliflozin Other Benfluorex‡ Bromocriptine Imeglimin...
Word Count : 888
Last Update: 2024-06-10T05:27:02Z
Ertugliflozin Ipragliflozin Luseogliflozin Remogliflozin§ Sergliflozin§ Sotagliflozin Tofogliflozin † Velagliflozin Other Benfluorex‡ Bromocriptine Imeglimin...
Word Count : 607
Last Update: 2024-06-12T11:03:36Z
Ertugliflozin Ipragliflozin Luseogliflozin Remogliflozin§ Sergliflozin§ Sotagliflozin Tofogliflozin † Velagliflozin Other Benfluorex‡ Bromocriptine Imeglimin...
Word Count : 2666
Last Update: 2024-04-27T22:39:33Z
Ertugliflozin Ipragliflozin Luseogliflozin Remogliflozin§ Sergliflozin§ Sotagliflozin Tofogliflozin † Velagliflozin Other Benfluorex‡ Bromocriptine Imeglimin...
Word Count : 2133
Last Update: 2024-06-24T03:48:27Z
Ertugliflozin Ipragliflozin Luseogliflozin Remogliflozin§ Sergliflozin§ Sotagliflozin Tofogliflozin † Velagliflozin Other Benfluorex‡ Bromocriptine Imeglimin...
Word Count : 507
Last Update: 2024-04-13T05:09:46Z
Ertugliflozin Ipragliflozin Luseogliflozin Remogliflozin§ Sergliflozin§ Sotagliflozin Tofogliflozin † Velagliflozin Other Benfluorex‡ Bromocriptine Imeglimin...
Word Count : 2074
Last Update: 2024-05-12T11:18:20Z
Mizagliflozin Phloretin Phlorizin Remogliflozin Sergliflozin T-1095 T-1095A Tofogliflozin Velagliflozin Antisense oligonucleotides: ISIS-388626 SGLT1Tooltip Sodium-glucose...
Word Count : 189
Last Update: 2024-06-17T09:11:04Z
Ertugliflozin Ipragliflozin Luseogliflozin Remogliflozin§ Sergliflozin§ Sotagliflozin Tofogliflozin † Velagliflozin Other Benfluorex‡ Bromocriptine Imeglimin...
Word Count : 284
Last Update: 2024-06-25T13:52:31Z
Ertugliflozin Ipragliflozin Luseogliflozin Remogliflozin§ Sergliflozin§ Sotagliflozin Tofogliflozin † Velagliflozin Other Benfluorex‡ Bromocriptine Imeglimin...
Word Count : 3343
Last Update: 2024-06-07T15:51:18Z
Ertugliflozin Ipragliflozin Luseogliflozin Remogliflozin§ Sergliflozin§ Sotagliflozin Tofogliflozin † Velagliflozin Other Benfluorex‡ Bromocriptine Imeglimin...
Word Count : 1514
Last Update: 2024-06-07T18:38:39Z
Ertugliflozin Ipragliflozin Luseogliflozin Remogliflozin§ Sergliflozin§ Sotagliflozin Tofogliflozin † Velagliflozin Other Benfluorex‡ Bromocriptine Imeglimin...
Word Count : 418