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Thymidine phosphorylase
Thymidine phosphorylase protein structure
Identifiers
EC no.
2.4.2.4
CAS no.
9030-23-3
Databases
IntEnz
IntEnz view
BRENDA
BRENDA entry
ExPASy
NiceZyme view
KEGG
KEGG entry
MetaCyc
metabolic pathway
PRIAM
profile
PDB structures
RCSB PDB PDBe PDBsum
Gene Ontology
AmiGO / QuickGO
Search
PMC
articles
PubMed
articles
NCBI
proteins
Thymidine phosphorylase (EC 2.4.2.4) is an enzyme that is encoded by the TYMP gene and catalyzes the reaction:
Thymidine phosphorylase is involved in purine metabolism, pyrimidine metabolism, and other metabolic pathways. Variations in thymidine phosphorylase and the TYMP gene that encode it are associated with mitochondrial neurogastrointestinal encephalopathy (MNGIE) syndrome and bladder cancer.
and 19 Related for: Thymidine phosphorylase information
Thymidinephosphorylase (EC 2.4.2.4) is an enzyme that is encoded by the TYMP gene and catalyzes the reaction: thymidine + phosphate ⇌ {\displaystyle \rightleftharpoons...
caused by mutations in the TYMP gene, which encodes the enzyme thymidinephosphorylase. Mutations in this gene result in impaired mitochondrial function...
Pyrimidine phosphorylase may refer to: Thymidinephosphorylase Uridine phosphorylase This article includes a list of related items that share the same...
can phosphorylate into uridine triphosphate. Thymidinephosphorylase or pyrimidine-nucleoside phosphorylase adds 2-deoxy-alpha-D-ribose 1-phosphate to thymine...
the blood concentration of trifluridine by inhibiting the enzyme thymidinephosphorylase which metabolizes trifluridine. Adverse effects were not assessed...
digestive system. Within a cell, pyrimidine nucleoside phosphorylase or thymidinephosphorylase can metabolize doxifluridine into 5-FU. It is also a metabolite...
influence blood plasma concentrations of trifluridine. Being a thymidinephosphorylase inhibitor, trifluridine could also interact with substrates of...
undergoes first-pass metabolism in the liver, where the enzyme thymidinephosphorylase quickly splits off the sugar component, leading to a bioavailability...
4.2.2, pyrimidine-nucleoside phosphorylase, EC 2.4.2.3, uridine phosphorylase, and EC 2.4.2.4, thymidinephosphorylase. These enzymes belong to the family...
Purine nucleoside phosphorylase, PNP, PNPase or inosine phosphorylase (EC 2.4.2.1) is an enzyme that in humans is encoded by the NP gene. It catalyzes...
of mitochondrial DNA polymerase. Other causes are mutations of thymidinephosphorylase (TyMP), succinate-CoA ligase, alpha sub unit (SUCLG1) and TWNK...
family of phosphotransferases. Kinases should not be confused with phosphorylases, which catalyze the addition of inorganic phosphate groups to an acceptor...
often shows low yields, De Winter et al. investigated use of cellobiose phosphorylase (CP) toward synthesis of alpha-glycosides in ionic liquids. The best...
"Expression of thymidylate synthase, dihydropyrimidine dehydrogenase, thymidinephosphorylase, and orotate phosphoribosyl transferase in prostate cancer". Prostate...
fibroblasts. Immobilized Aeromonas salmonicida ATCC 27013, when exposed to thymidine and 5-fluorouracil in phosphate buffer at room temperature for one hour...
have been observed to develop chemoresistance to the drug. Nucleoside phosphorylase GRCh38: Ensembl release 89: ENSG00000156136 – Ensembl, May 2017 GRCm38:...