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Thymidine phosphorylase information


Thymidine phosphorylase
Thymidine phosphorylase protein structure
Identifiers
EC no.2.4.2.4
CAS no.9030-23-3
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
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NCBIproteins

Thymidine phosphorylase (EC 2.4.2.4) is an enzyme that is encoded by the TYMP gene and catalyzes the reaction:

thymidine + phosphate thymine + 2-deoxy-alpha-D-ribose 1-phosphate

Thymidine phosphorylase is involved in purine metabolism, pyrimidine metabolism, and other metabolic pathways. Variations in thymidine phosphorylase and the TYMP gene that encode it are associated with mitochondrial neurogastrointestinal encephalopathy (MNGIE) syndrome and bladder cancer.

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Thymidine phosphorylase

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Thymidine phosphorylase (EC 2.4.2.4) is an enzyme that is encoded by the TYMP gene and catalyzes the reaction: thymidine + phosphate ⇌ {\displaystyle \rightleftharpoons...

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Mitochondrial neurogastrointestinal encephalopathy syndrome

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caused by mutations in the TYMP gene, which encodes the enzyme thymidine phosphorylase. Mutations in this gene result in impaired mitochondrial function...

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Pyrimidine phosphorylase

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Pyrimidine phosphorylase may refer to: Thymidine phosphorylase Uridine phosphorylase This article includes a list of related items that share the same...

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Nucleotide salvage

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can phosphorylate into uridine triphosphate. Thymidine phosphorylase or pyrimidine-nucleoside phosphorylase adds 2-deoxy-alpha-D-ribose 1-phosphate to thymine...

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Tipiracil

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the blood concentration of trifluridine by inhibiting the enzyme thymidine phosphorylase which metabolizes trifluridine. Adverse effects were not assessed...

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Doxifluridine

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digestive system. Within a cell, pyrimidine nucleoside phosphorylase or thymidine phosphorylase can metabolize doxifluridine into 5-FU. It is also a metabolite...

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Michael Kearney

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His 118-page thesis was entitled "Kinetic Isotope Effects of Thymidine Phosphorylase"; the research focused on the kinetics of a glycosyltransferase...

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Trifluridine

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influence blood plasma concentrations of trifluridine. Being a thymidine phosphorylase inhibitor, trifluridine could also interact with substrates of...

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Brivudine

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undergoes first-pass metabolism in the liver, where the enzyme thymidine phosphorylase quickly splits off the sugar component, leading to a bioavailability...

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Deoxyuridine phosphorylase

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4.2.2, pyrimidine-nucleoside phosphorylase, EC 2.4.2.3, uridine phosphorylase, and EC 2.4.2.4, thymidine phosphorylase. These enzymes belong to the family...

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Purine nucleoside phosphorylase

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Purine nucleoside phosphorylase, PNP, PNPase or inosine phosphorylase (EC 2.4.2.1) is an enzyme that in humans is encoded by the NP gene. It catalyzes...

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Mitochondrial DNA depletion syndrome

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of mitochondrial DNA polymerase. Other causes are mutations of thymidine phosphorylase (TyMP), succinate-CoA ligase, alpha sub unit (SUCLG1) and TWNK...

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UPP1

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M, Toi M, Uchida T (January 2002). "Expression of uridine and thymidine phosphorylase genes in human breast carcinoma". Int J Cancer. 97 (5): 631–5....

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Kinase

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family of phosphotransferases. Kinases should not be confused with phosphorylases, which catalyze the addition of inorganic phosphate groups to an acceptor...

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Glycosidic bond

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often shows low yields, De Winter et al. investigated use of cellobiose phosphorylase (CP) toward synthesis of alpha-glycosides in ionic liquids. The best...

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Uridine monophosphate synthase

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"Expression of thymidylate synthase, dihydropyrimidine dehydrogenase, thymidine phosphorylase, and orotate phosphoribosyl transferase in prostate cancer". Prostate...

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List of biomolecules

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Glycerin (glycerol) Glycine Glycogen Glycogenin Glycogen synthase Glycogen phosphorylase Glycolic acid Glycolipid Glycoprotein Gonadotropin-releasing hormone...

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Floxuridine

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fibroblasts. Immobilized Aeromonas salmonicida ATCC 27013, when exposed to thymidine and 5-fluorouracil in phosphate buffer at room temperature for one hour...

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Deoxycytidine kinase

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have been observed to develop chemoresistance to the drug. Nucleoside phosphorylase GRCh38: Ensembl release 89: ENSG00000156136 – Ensembl, May 2017 GRCm38:...

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