UPP1 information

UPP1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3EUE, 3EUF, 3NBQ
Identifiers
Aliases	UPP1, UDRPASE, UP, UPASE, UPP, uridine phosphorylase 1
External IDs	OMIM: 191730; MGI: 1097668; HomoloGene: 2524; GeneCards: UPP1; OMA:UPP1 - orthologs
Gene location (Human)
Chr.	Chromosome 7 (human)
End	48,108,736 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	9,086,170 bp
RNA expression pattern
	Top expressed in
	right hemisphere of cerebellum; ; granulocyte; ; upper lobe of left lung; ; monocyte; ; gonad; ; blood; ; buccal mucosa cell; ; mucosa of transverse colon; ; right frontal lobe; ; right lung;
	Top expressed in
	jejunum; ; duodenum; ; conjunctival fornix; ; primary oocyte; ; blastocyst; ; granulocyte; ; left colon; ; corneal stroma; ; mucous cell of stomach; ; endothelial cell of lymphatic vessel;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity; catalytic activity; pentosyltransferase activity; glycosyltransferase activity; uridine phosphorylase activity;
Cellular component	cytoplasm; cytosol; nucleus; nucleoplasm;
Biological process	pyrimidine nucleoside salvage; pyrimidine nucleotide metabolic process; nucleoside metabolic process; uridine metabolic process; nucleotide catabolic process; cellular response to glucose starvation; nucleobase-containing compound metabolic process; pyrimidine nucleoside catabolic process; UMP salvage; uridine catabolic process;
	Sources:Amigo / QuickGO
Orthologs
	7378
	22271
	ENSG00000183696
	ENSMUSG00000020407
	Q16831
	P52624
NM_001287426; NM_001287428; NM_001287429; NM_001287430; NM_003364;
	NM_181597; NM_001362774
	NM_001159401; NM_001159402; NM_009477
NP_001274355; NP_001274357; NP_001274358; NP_001274359; NP_003355;
	NP_001349703
	NP_001152873; NP_001152874; NP_033503
	Wikidata
View/Edit Human	View/Edit Mouse

Uridine phosphorylase 1 is an enzyme that in humans is encoded by the UPP1 gene.^[5]^[6]^[7] It belongs to the uridine phosphorylase enzyme family.

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000183696 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000020407 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Denney RM, Nichols EA, Ruddle FH (September 1979). "Assignment of a gene for uridine phosphorylase to chromosome 7". Cytogenet Cell Genet. 22 (1–6): 195–9. doi:10.1159/000130934. PMID 752472.
^ Kanzaki A, Takebayashi Y, Bando H, Eliason JF, Watanabe Si S, Miyashita H, Fukumoto M, Toi M, Uchida T (January 2002). "Expression of uridine and thymidine phosphorylase genes in human breast carcinoma". Int J Cancer. 97 (5): 631–5. doi:10.1002/ijc.10105. PMID 11807789. S2CID 40565516.
^ "Entrez Gene: UPP1 uridine phosphorylase 1".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000183696 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000020407 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid752472-5] Denney RM, Nichols EA, Ruddle FH (September 1979). "Assignment of a gene for uridine phosphorylase to chromosome 7". Cytogenet Cell Genet. 22 (1–6): 195–9. doi:10.1159/000130934. PMID 752472.

[pmid11807789-6] Kanzaki A, Takebayashi Y, Bando H, Eliason JF, Watanabe Si S, Miyashita H, Fukumoto M, Toi M, Uchida T (January 2002). "Expression of uridine and thymidine phosphorylase genes in human breast carcinoma". Int J Cancer. 97 (5): 631–5. doi:10.1002/ijc.10105. PMID 11807789. S2CID 40565516.

[entrez-7] "Entrez Gene: UPP1 uridine phosphorylase 1".

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