Global InformationDeoxyuridine phosphorylase information
| deoxyuridine phosphorylase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.4.2.23 | ||||||||
| CAS no. | 37277-77-3 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
In enzymology, a deoxyuridine phosphorylase is an enzyme that catalyzes the chemical reaction
- 2'-deoxyuridine + phosphate uracil + 2-deoxy-alpha-D-ribose 1-phosphate
Thus, the two substrates of this enzyme are 2'-deoxyuridine and phosphate, whereas its two products are uracil and 2-deoxy-alpha-D-ribose 1-phosphate.
No enzyme is known to be specific for this reaction, hence the EC number originally assigned to this enzyme function (EC 2.4.2.23) was deleted by the IUBMB in 2013.[1] The reaction is catalysed by EC 2.4.2.2, pyrimidine-nucleoside phosphorylase, EC 2.4.2.3, uridine phosphorylase, and EC 2.4.2.4, thymidine phosphorylase.
These enzymes belong to the family of glycosyltransferases, specifically the pentosyltransferases. They participate in pyrimidine metabolism.
- ^ "ExplorEnz: EC 2.4.2.23".