Trifluridine (also called trifluorothymidine; abbreviation TFT or FTD[1]) is an anti-herpesvirus antiviral drug, used primarily on the eye. It was sold under the trade name Viroptic by Glaxo Wellcome, now merged into GlaxoSmithKline. The brand is now owned by Monarch Pharmaceuticals, which is wholly owned by King Pharmaceuticals.
Trifluridine was approved for medical use in 1980.[2] It is also a component of the anti-cancer drug trifluridine/tipiracil, which is taken by mouth.
^Patel AK, Abhyankar R, Brais LK, Duh MS, Barghout VE, Huynh L, et al. (December 2021). "Trifluridine/Tipiracil and Regorafenib in Patients with Metastatic Colorectal Cancer: A Retrospective Study at a Tertiary Oncology Center". The Oncologist. 26 (12): e2161–e2169. doi:10.1002/onco.13942. PMC 8649060. PMID 34406678.
^Kimberlin DW (2012). "Antiviral Agents". In Long SS, Pickering LK, Prober CG (eds.). Principles and Practice of Pediatric Infectious Disease. Elsevier Health Sciences. p. 1502. ISBN 978-1437727029.
Trifluridine (also called trifluorothymidine; abbreviation TFT or FTD) is an anti-herpesvirus antiviral drug, used primarily on the eye. It was sold under...
maintain the blood concentration of trifluridine by inhibiting the enzyme thymidine phosphorylase which metabolizes trifluridine. Adverse effects were not assessed...
3H)-pyrimidinedione, the main metabolite of the pharmaceutical drug trifluridine This disambiguation page lists articles associated with the title FTY...
the thyroid Thought Field Therapy, a type of Energy psychology therapy Trifluridine, an antiviral and anticancer medication The Fire Theft, a rock band associated...
uridine but without the presence of the 2' hydroxyl group. Idoxuridine and Trifluridine are variants of deoxyuridine used as antiviral drugs. They are similar...
Examples include naturally occurring metabolites: drugs: Fluorouracil Idoxuridine Primidone Trifluridine and pesticides: Bromacil Saflufenacil v t e...
alafenamide Hepatitis B Tenofovir disoproxil Hepatitis B, HIV Tipranavir HIV Trifluridine Eyes related Herpes Trizivir HIV Tromantadine Herpes Simplex Truvada...
should be continued for 10–14 days. Aciclovir ophthalmic ointment and Trifluridine eye drops have similar effectiveness but are more effective than Idoxuridine...
zidovudine (azidothymidine, or AZT)(HIV) deoxyuridine analogues: idoxuridine trifluridine Related drugs are nucleobase analogs, which don't include a sugar or...
an anti-EGFR biological therapy if RAS wild type, and at least one of trifluridine/tipiracil or regorafenib. FRESCO, a multicenter, placebo-controlled trial...
Valganciclovir Vidarabine Pyrimidine analogues of uridine: Idoxuridine, Trifluridine Brivudine Mutations in the gene coding thymidine kinase in herpes viruses...
after healing is complete, as demonstrated by fluorescein staining. Trifluridine Acyclovir Foscarnet Prusoff WH (March 1959). "Synthesis and biological...
carfilzomib, sirolimus (rapamycin), imatinib (Gleevec), sunitinib, trifluridine, and aminolevulinic acid. GT198 has protein sequence homology with DNA...
kinase 1 and deoxyUTPase in incorporating the antineoplastic nucleosides trifluridine and 2'-deoxy-5-fluorouridine into DNA". International Journal of Oncology...
didanosine (ddI), zalcitabine (ddC), lamivudine (3TC), stavudine (d4T), trifluridine, cidofovir, adefovir, and tenofovir (TDF) are substrates of the OAT1...
this process was successfully applied to the commercial synthesis of trifluridine (trifluorothymidine), an antiherpes antiviral drug, primarily used on...
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