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Brivudine information


Brivudine
Clinical data
Trade namesZostex, Mevir, Brivir, many others
Other namesBVDU
AHFS/Drugs.comInternational Drug Names
Pregnancy
category
  • Contraindicated
Routes of
administration		Oral
ATC code
  • J05AB15 (WHO)
Legal status
Legal status
  • In general: ℞ (Prescription only)
Pharmacokinetic data
Bioavailability30%
Protein binding>95%
MetabolismThymidine phosphorylase
MetabolitesBromovinyluracil
Elimination half-life16 hours
Excretion65% renal (mainly metabolites), 20% faeces
Identifiers
IUPAC name
  • 5-[(E)-2-bromoethenyl]-1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,2,3,4-tetrahydropyrimidine-2,4-dione
CAS Number
  • 69304-47-8 ☒N
PubChem CID
  • 446727
ChemSpider
  • 394011 checkY
UNII
  • 2M3055079H
KEGG
  • D07249 ☒N
ChEMBL
  • ChEMBL31634 checkY
CompTox Dashboard (EPA)
  • DTXSID0045755 Edit this at Wikidata
Chemical and physical data
FormulaC11H13BrN2O5
Molar mass333.138 g·mol−1
3D model (JSmol)
  • Interactive image
Specific rotation+9°±1°
Density1.86 g/cm3
Melting point165 to 166 °C (329 to 331 °F) (decomposes)
SMILES
  • Br[C@H]=CC=1C(=O)NC(=O)N(C=1)[C@@H]2O[C@@H]([C@@H](O)C2)CO
InChI
  • InChI=1S/C11H13BrN2O5/c12-2-1-6-4-14(11(18)13-10(6)17)9-3-7(16)8(5-15)19-9/h1-2,4,7-9,15-16H,3,5H2,(H,13,17,18)/b2-1+/t7-,8+,9+/m0/s1 checkY
  • Key:ODZBBRURCPAEIQ-PIXDULNESA-N checkY
 ☒NcheckY (what is this?)  (verify)

Brivudine (trade names Zostex, Mevir, Brivir, among others) is an antiviral drug used in the treatment of herpes zoster ("shingles"). Like other antivirals, it acts by inhibiting replication of the target virus.

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Brivudine

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Brivudine (trade names Zostex, Mevir, Brivir, among others) is an antiviral drug used in the treatment of herpes zoster ("shingles"). Like other antivirals...

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Capecitabine

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related analogues, such as brivudine Drugs it is known to interact with include: Sorivudine or its analogues, such as, brivudine. CYP2C9 substrates, including...

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Aciclovir

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idoxuridine. It is not clear if aciclovir eye drops are more effective than brivudine eye drops. Intravenous aciclovir is effective to treat severe medical...

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Herpes simplex keratitis

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oral therapy is preferred by some ophthalmologists. Ganciclovir and brivudine treatments were found to be equally as effective as acyclovir in a systematic...

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BVDU

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BVDU is the abbreviation for: Brivudine (bromovinyldeoxyuridine), an antiviral drug Bharati Vidyapeeth Deemed University This disambiguation page lists...

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Thymidine kinase from herpesvirus

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Vidarabine Pyrimidine analogues of uridine: Idoxuridine, Trifluridine Brivudine Mutations in the gene coding thymidine kinase in herpes viruses can endow...

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BVU

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Utilities, USA utility company Bromovinyluracil, the metabolite of the drugs brivudine and sorivudine This disambiguation page lists articles associated with...

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ATC code J05

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J05AB12 Cidofovir J05AB13 Penciclovir J05AB14 Valganciclovir J05AB15 Brivudine J05AB16 Remdesivir J05AB17 Brincidofovir J05AB18 Molnupiravir J05AC02...

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Thymectacin

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Thymectacin (NB-1011, NB-101) is an experimental anticancer prodrug of brivudine monophosphate. It is being developed by New Biotics and it entered in...

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Sorivudine

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(DPD) which is necessary for inactivating 5-FU. The closely related drug brivudine has the same interaction. Also, it should be taken into consideration...

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Index of oncology articles

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breast-conserving surgery – breast-sparing surgery – Brief Pain Inventory – BRIP1 – brivudine – BRM – bromelain – bronchiole – bronchitis – bronchoscope – bronchoscopy...

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Rega Institute for Medical Research

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(alpha-APA) were first described at the Rega Institute. The anti-viral drugs Brivudine and Tenofovir were discovered at the Rega Institute. Wikimedia Commons...

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