Tetmethylcytosinedioxygenase 2 (TET2) is a human gene. It resides at chromosome 4q24, in a region showing recurrent microdeletions and copy-neutral loss...
Ten-eleven translocation methylcytosinedioxygenase 1 (TET1) is a member of the TET family of enzymes, in humans it is encoded by the TET1 gene. Its function...
TET enzymes are a family of ten-eleven translocation (TET) methylcytosinedioxygenases. They are instrumental in DNA demethylation. 5-Methylcytosine (see...
are a ten-eleven translocation methylcytosinedioxygenase (TET) and thymine-DNA glycosylase (TDG). One particular TET enzyme, TET1, and TDG are present...
demethylation, replacement of 5-methylcytosine by cytosine. At the La Jolla Institute, her lab demonstrated the importance of TET enzymes in proper gene expression...
turn reduces the levels of inflammation-promoting cytokines. Tetmethylcytosinedioxygenase 2 (i.e., TET2) is an enzyme that is activated by the tricarboxylic...
ten-eleven translocation (TET) family of dioxygenases (TET1, TET2, TET3) to generate 5-hydroxymethylcytosine (5hmC). In successive steps TET enzymes further hydroxylate...
central roles of ten-eleven translocation methylcytosinedioxygenases (TETs) in the demethylation of 5-methylcytosine to form cytosine. As reviewed in 2018...
methylation. Succinate and fumarate inhibit the TET (ten-eleven translocation) family of 5-methylcytosine DNA modifying enzymes and the JmjC domain-containing...
about 3.5-fold in DNA and this caused about 80% demethylation of the 5-methylcytosines in the genome. Demethylation of CpGs in a gene promoter by TET enzyme...
deamination of guanine. (Thymidine products following deamination of 5-methylcytosine are more difficult to recognize, but can be repaired by mismatch-specific...
in the Figure below, titled "Demethylation of 5-Methylcytosine (5mC) in neuron DNA," especially the TET dependent pathway, have been confirmed as pathways...
demethylases (KDMs) and ten-eleven translocation (TET) enzymes; ordinarily TETs hydroxylate 5-methylcytosines to prime them for demethylation. However, in...
are located on chromosomes 21, 6, and 4, respectively (21q22.1, 6q25.3 and 4p15.3-p15.1). The SOD-catalysed dismutation of superoxide may be written with...
(YSPTSPSYS) repeats. Interaction between homeobox protein NANOG and Tetmethylcytosinedioxygenase 1 (TET1) has been shown to be important in establishing pluripotency...
section shows a CpG site where the cytosine is methylated to form 5-methylcytosine (5mC) and the guanine is oxidized to form 8-oxo-2'-deoxyguanosine (in...