While the cellular and molecular mechanisms of learning and memory have long been a central focus of neuroscience, it is only in recent years that attention has turned to the epigenetic mechanisms behind the dynamic changes in gene transcription responsible for memory formation and maintenance. Epigenetic gene regulation often involves the physical marking (chemical modification) of DNA or associated proteins to cause or allow long-lasting changes in gene activity. Epigenetic mechanisms such as DNA methylation and histone modifications (methylation, acetylation, and deacetylation) have been shown to play an important role in learning and memory.[1]
^Rumbaugh G, Miller CA (2011). "Epigenetic changes in the brain: measuring global histone modifications". Alzheimer's Disease and Frontotemporal Dementia. Methods in Molecular Biology. Vol. 670. pp. 263–74. doi:10.1007/978-1-60761-744-0_18. ISBN 978-1-60761-743-3. PMC 3235043. PMID 20967596.
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