Telomere-restoring protein active in the most rapidly dividing cells
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Tribolium castaneum telomerase catalytic subunit, TERT, bound to putative RNA template and telomeric DNA (PDB 3KYL)A conceptual diagram showing the protein component of telomerase (TERT) in grey and the RNA component (TR) in yellow
Telomerase, also called terminal transferase,[1] is a ribonucleoprotein that adds a species-dependent telomere repeat sequence to the 3' end of telomeres. A telomere is a region of repetitive sequences at each end of the chromosomes of most eukaryotes. Telomeres protect the end of the chromosome from DNA damage or from fusion with neighbouring chromosomes. The fruit fly Drosophila melanogaster lacks telomerase, but instead uses retrotransposons to maintain telomeres.[2]
Telomerase is a reverse transcriptase enzyme that carries its own RNA molecule (e.g., with the sequence 3′-CCCAAUCCC-5′ in Trypanosoma brucei)[3] which is used as a template when it elongates telomeres. Telomerase is active in gametes and most cancer cells, but is normally absent in most somatic cells.
^"What are telomeres and telomerase?". Archived from the original on 2014-05-30. Retrieved 2014-05-30.
^Cano MI, Dungan JM, Agabian N, Blackburn EH (March 1999). "Telomerase in kinetoplastid parasitic protozoa". Proceedings of the National Academy of Sciences of the United States of America. 96 (7): 3616–21. Bibcode:1999PNAS...96.3616C. doi:10.1073/pnas.96.7.3616. PMC 22343. PMID 10097086.
Telomerase, also called terminal transferase, is a ribonucleoprotein that adds a species-dependent telomere repeat sequence to the 3' end of telomeres...
Telomerase reverse transcriptase (abbreviated to TERT, or hTERT in humans) is a catalytic subunit of the enzyme telomerase, which, together with the telomerase...
discovery of how chromosomes are protected by telomeres and the enzyme telomerase. During DNA replication, DNA polymerase cannot replicate the sequences...
Salk Institute for Biological Studies. In 1984, Blackburn co-discovered telomerase, the enzyme that replenishes the telomere, with Carol W. Greider. For...
Telomerase RNA component, also known as TR, TER or TERC, is an ncRNA found in eukaryotes that is a component of telomerase, the enzyme used to extend telomeres...
syndromes with transfusion-dependent anemia. Imetelstat is an oligonucleotide telomerase inhibitor. The most common adverse reactions include decreased platelets...
to activate telomerase more than any other known compound yet discovered: 8.8-fold. This exceeds the activation by other known telomerase activators:...
to telomerase, an enzyme that repairs long repetitive sections of DNA sequences at the ends of chromosomes, referred to as telomeres. Telomerase is expressed...
Greider, and Jack Szostak in the 1980s led to the successful discovery of telomerase (the enzyme responsible for maintaining telomere length) and a better...
developing and commercializing therapeutic products for cancer that inhibit telomerase. Geron, based in Foster City, California, was founded by gerontologist...
Metastases suppressor NME2 associates with telomere ends and telomerase and reduces telomerase activity within cells. Oxford University Press. OCLC 794927394...
cancers reactivation of telomerase is actually a required step for malignancy to evolve (see telomere). In a disease where telomerase is affected, it does...
various legume species in the genus Astragalus that is purported to have telomerase activation activity. A preliminary in vitro study on human CD4 and CD8...
reversing it. Cultures not containing telomerase-active pluripotent stem cells would have been populated with telomerase-inactive cells, which would have been...
cells. Like many other cancer cells, HeLa cells have an active version of telomerase during cell division, which copies telomeres over and over again. This...
reactions. He also studied telomeres, and his lab discovered an enzyme, TERT (telomerase reverse transcriptase), which is part of the process of restoring telomeres...
to telomerase, an enzyme that repairs long repetitive sections of DNA sequences at the ends of chromosomes, referred to as telomeres. Telomerase is expressed...
the normal levels of telomerase lived 50% longer than normal mice". In normal circumstances, without the presence of telomerase, if a cell divides repeatedly...
features that make them "immortal" according to some researchers. The enzyme telomerase is used to extend the cancer cell's life span. While the telomeres of...
involved breeding genetically manipulated mice that lacked an enzyme called telomerase, causing the mice to age prematurely and suffer ailments. When the mice...
Epitalon is a synthetic peptide, telomerase activator, and putative anti-aging compound, which was identified as the putative active component of a bovine...
in many eukaryotes from DNA repair mechanisms, as well as to regulate telomerase activity. In mammals and other vertebrates, telomeric DNA consists of...
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