Tachyphylaxis (Greek ταχύς, tachys, "rapid", and φύλαξις, phylaxis, "protection") is a medical term describing an acute, sudden decrease in response to a drug after its administration;[1] i.e. a rapid and short-term onset of drug tolerance. It can occur after an initial dose or after a series of small doses. Increasing the dose of the drug may be able to restore the original response.[2]
^Bunnel, Craig A. Intensive Review of Internal Medicine, Harvard Medical School 2009.[page needed]
^Lehne, Richard A. (2013). "Tachyphylaxis". Pharmacology for Nursing Care. Philadelphia: Saunders. p. 81. ISBN 978-1-4377-3582-6.
Nicotine may also show tachyphylaxis over the course of a day, although the mechanism of this action is unclear. Acute tachyphylaxis which does not carry...
Antidepressant treatment tachyphylaxis (ADT tachyphylaxis), also known as Prozac poop-out, is a medical condition in which progressive or acute tolerance...
which overt adverse effects of a drug can be tolerated by a patient. Tachyphylaxis is a subcategory of drug tolerance referring to cases of sudden, short-term...
adverse effects. Tachyphylaxis: The acute development of tolerance to the action of a drug after repeated doses. Significant tachyphylaxis can occur by day...
nervousness. Topical nasal or ophthalmic decongestants quickly develop tachyphylaxis (a rapid decrease in the response to a drug after repeated doses over...
blood concentrations observed in rodent studies. LSD shows significant tachyphylaxis, with tolerance developing 24 hours after administration. The progression...
Redosing usually requires increased doses to offset the development of tachyphylaxis, which is attributed to the depletion of catecholamine stores. Ephedrine...
anticonvulsant therapeutic effects. With prolonged use, tolerance and tachyphylaxis can occur and the elimination half-life may increase, up to days. Buccal...
Lipworth B (July 2010). "Fluticasone reverses oxymetazoline-induced tachyphylaxis of response and rebound congestion". American Journal of Respiratory...
Meller J, Gorlin R, Herman MV (March 1979). "Hemodynamic and clinical tachyphylaxis to prazosin-mediated afterload reduction in severe chronic congestive...
daily use at up to 300 mg/day. Moreover, there was no evidence of the tachyphylaxis typical of neuroactive agents like caffeine and other stimulants. In...
improve emptying of the stomach but its effects are temporary due to tachyphylaxis and wane after a few weeks of consistent use. Sildenafil citrate, which...
hydralazine monotherapy was that it lost its effectiveness over time (tachyphylaxis). In the mid-1950s Karl H. Beyer, James M. Sprague, John E. Baer, and...
neurotransmitters into the synaptic cleft through their reuptake transporters. Tachyphylaxis and tolerance have been demonstrated with all drugs of this class.[medical...
History of Human Knowledge: on habituation Preference tests (animals) Tachyphylaxis, the effect of continued exogenous entries (habituation of) into the...
should be revisited." Downregulation and upregulation Rebound effect Tachyphylaxis Feig, Christy (2000-01-21). "AIDS virus stays in check during drug holiday...
hypotension. Nitrates exhibit development of tolerance, or more specifically tachyphylaxis, meaning that repeated application results in a fast decrease of effect...
dosing is recommended during therapy with estradiol pellet implants. Tachyphylaxis of relief of vasomotor symptoms, or hot flashes returning even with...
Global Information