Simple abdominal X-ray reveals a large amount of material in the stomach, suggesting severe gastric hypomotility
Pronunciation
(/,ɡæstroʊ,pəˈriːsɪs/)[1]
Specialty
Gastroenterology
Symptoms
Nausea, vomiting, abdominal pain, feeling full after eating just a few bites
Complications
Malnutrition, fatigue, weight loss, vitamin deficiencies, intestinal obstruction due to bezoars, and small intestine bacterial overgrowth.
Causes
Damage to the vagus nerve,[2] chemotherapy-induced neuropathy,[3] and autonomic neuropathy.[4]
Risk factors
Diabetes, abdominal or esophageal surgery, infection, certain medications that slow the rate of stomach emptying, scleroderma, nervous system diseases, and hypothyroidism.[2]
Diagnostic method
Barium swallow X-ray, barium beefsteak meal, radioisotope gastric-emptying scan (GES), wireless motility capsule (WMC), serial X-ray after ingesting radiopaque markers (ROM), gastric manometry, esophagogastroduodenoscopy (EGD), and a stable isotope breath test.
Treatment
Dietary modifications, medications to stimulate gastric emptying, medications to reduce vomiting,[5] and gastric electrical stimulation.[6]
Frequency
possibly up to 4%[citation needed]
Gastroparesis (gastro- from Ancient Greek γαστήρ – gaster, "stomach"; and -paresis, πάρεσις – "partial paralysis"), also called delayed gastric emptying is a medical disorder consisting of weak muscular contractions (peristalsis) of the stomach, resulting in food and liquid remaining in the stomach for a prolonged period of time. Stomach contents thus exit more slowly into the duodenum of the digestive tract. This can result in irregular absorption of nutrients, inadequate nutrition, and poor glycemic control.[7][8] The opposite of this, where stomach contents exit quickly into the duodenum is called dumping syndrome.
Symptoms include nausea, vomiting, abdominal pain, feeling full soon after beginning to eat (early satiety), abdominal bloating, and heartburn. The most common known mechanism is autonomic neuropathy of the nerve which innervates the stomach: the vagus nerve. Uncontrolled diabetes mellitus is a major cause of this nerve damage; other causes include post-infectious and trauma to the vagus nerve.
Diagnosis is via one or more of the following: barium swallow X-ray, barium beefsteak meal, radioisotope gastric-emptying scan, gastric manometry, esophagogastroduodenoscopy (EGD), and a stable isotope breath test. Complications include malnutrition, fatigue, weight loss, vitamin deficiencies, intestinal obstruction due to bezoars, and small intestine bacterial overgrowth. Patient nutritional state should be managed by oral dietary modification, or if oral intake is not adequate through a jejunostomy feeding tube.[6]
Treatment includes dietary modifications, medications to stimulate gastric emptying, medications to reduce vomiting, and surgical approaches.[5] Additionally, gastric electrical stimulation (GES; approved on a humanitarian device exemption) can be used as treatment.[6] Overall survival in gastroparesis patients is significantly lower than survival in the general population.[9] It is associated with poor outcomes.[9]
^"How to pronounce gastroparesis in English". dictionary.cambridge.org.
^ abCite error: The named reference :2 was invoked but never defined (see the help page).
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^ abCite error: The named reference Thorn2010 was invoked but never defined (see the help page).
^ abcCamilleri M, Kuo B, Nguyen L, Vaughn VM, Petrey J, Greer K, et al. (August 2022). "ACG Clinical Guideline: Gastroparesis". The American Journal of Gastroenterology. 117 (8): 1197–1220. doi:10.14309/ajg.0000000000001874. PMC 9373497. PMID 35926490.
^. In: Simpson, Kathleen Rice, Creehan, Patricia A. eds. AWHONN's Perinatal Nursing. 4th Edition. 530 Walnut Street, Philadelphia, PA 19106 USA:Lippincott Williams & Wilkins; 2014. Available from: Books@Ovid at [1]. Retrieved November 09, 2020.
^Fuglsang J, Ovesen PG (2015). "Pregnancy and Delivery in a Woman with Type 1 Diabetes, Gastroparesis, and a Gastric Neurostimulator". Diabetes Care. 38 (5): e75. doi:10.2337/dc14-2959. PMID 25908160. S2CID 34451324.
^ abJung HK, Choung RS, Locke GR, Schleck CD, Zinsmeister AR, Szarka LA, et al. (April 2009). "The incidence, prevalence, and outcomes of patients with gastroparesis in Olmsted County, Minnesota, from 1996 to 2006". Gastroenterology. 136 (4). Elsevier BV: 1225–1233. doi:10.1053/j.gastro.2008.12.047. PMC 2705939. PMID 19249393.
affecting 90% of gastroparesis patients. Idiopathic gastroparesis patients may experience more abdominal pain than diabetic gastroparesis patients. Physicians...
gastrointestinal peristalsis and hence to treat gastroparesis. It may be useful in idiopathic and diabetic gastroparesis. However, increased rate of gastric emptying...
very common long-term problem which is now more appreciated is gastroparesis. Gastroparesis affects millions of individuals and is often never suspected...
complications after gastric surgery, for gastric reflux, or suspected gastroparesis amongst other indications. Scintigraphy that uses gamma cameras to create...
brother is a violinist and her sister is a classical singer. Kok has gastroparesis and has been dependent on a feeding tube since the age of nine months...
phase II clinical trials assessing its utility in the treatment of gastroparesis the results of which were announced on December 3, 2018. In a study...
metopimazine, is under clinical development for idiopathic gastroparesis in the United States. Gastroparesis is a debilitating chronic gastrointestinal disorder...
seldom re-swallow food. Gastroparesis is another common misdiagnosis. Like rumination syndrome, patients with gastroparesis often bring up food following...
ondansetron. The granisetron patch (Sancuso) has been studied for use in gastroparesis, though it is not FDA approved for this indication. Is a possible therapy...
or in combination with aspirin. Evidence also supports its use for gastroparesis, a condition that causes the stomach to empty poorly, and as of 2010...
to describe the muscles of the eyes (ophthalmoparesis), the stomach (gastroparesis), and also the vocal cords (vocal cord paresis). Neurologists use the...
occur, such as vomiting, a coexisting or alternative condition, like gastroparesis, needs to be evaluated. Functional dyspepsia has a wide range of complex...
well in gastroparesis study". Seeking Alpha. Retrieved 2017-05-10. Morales S (2016-12-18). "FDA Gives Fast Track Designation for Gastroparesis Treatment"...
gastrointestinal disorders, including irritable bowel syndrome, gastritis, gastroparesis, and functional dyspepsia. Most prokinetic agents are grouped under...
development by Allergan pharmaceuticals for the treatment of diabetic gastroparesis, chronic idiopathic constipation, and anorexia nervosa. It is a pentapeptide...
result from chronic compression of the celiac artery. They include gastroparesis and aneurysm of the superior and inferior pancreaticoduodenal arteries...
Gonzalez Z (2021). "Antiemetic therapy for gastroparesis". In McCallum RW, Parkman HP (eds.). Gastroparesis. Elsevier. pp. 341–359. doi:10.1016/B978-0-12-818586-5...
the treatment of gastroparesis. Barshop K, Kuo B (January 2015). "The investigational drug camicinal for the treatment of gastroparesis". Expert Opinion...
momentarily retiring from competitive grappling due to his long–time gastroparesis condition, as it had worsened throughout the years, and looks forward...
try to bring about weight loss in those who are overweight or improve gastroparesis. Gastric electrical stimulation is a pacemaker-like device with electrical...
used as a treatment for gastroparesis.[citation needed] Soffer, Edy E (2012). "Gastric Electrical Stimulation for Gastroparesis". Journal of Neurogastroenterology...
acid reflux to form esophageal bezoars. Bezoars can also be caused by gastroparesis due to the slowing of gastric emptying, which allows food to form a...
gastroesophageal reflux disease (GERD). It can also cause pancreatitis, gastroparesis, and bowel obstruction. The US FDA label for semaglutide contains a...
irritability, depression or mania, delirium, hallucinations, hypoventilation, gastroparesis, bradycardia, and hypotension. Those allergic to codeine may also be...
arrest. Autonomic dysfunction symptoms such as orthostatic hypotension, gastroparesis, and gustatory sweating are more frequently identified in mortalities...