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TK is an experimental cell therapy which may be used to treat high-risk leukemia. It is currently undergoing a Phase III clinical trial to determine efficacy and clinical usefulness.[1][2]
TK is currently being investigated in patients with acute leukemia in first or subsequent complete remission and at high risk of relapse or in patients with relapsed disease who are candidates for haploidentical transplantation of hemopoietic stem cells (taken from a partially HLA-compatible family donor).[3]
^"TK008: Randomized Phase III Trial of Haploidentical HCT with or Without an Add Back Strategy of HSV-Tk Donor Lymphocytes in Patients with High Risk Acute Leukemia". 12 September 2018.
^TK scientific results and regulatory path will be presented today at the 40° annual meeting of the European Society for Blood and Marrow Transplantation
^"Ciceri F, Bonini C, Stanghellini MT, et al. Infusion of suicide-gene-engineered donor lymphocytes after family haploidentical haemopoietic stem-cell transplantation for leukaemia (the TK007 trial): a non-randomised phase I-II study". Lancet Oncol 2009;10(5):489-500.
TK is an experimental celltherapy which may be used to treat high-risk leukemia. It is currently undergoing a Phase III clinical trial to determine efficacy...
antigen-binding and T cell activating functions into a single receptor. CAR T celltherapy uses T cells engineered with CARs to treat cancer. T cells are modified...
Sickle Cell Had Devastating, and Preventable, Strokes". The New York Times. Aldrich TK, Nagel RL (1998). "Pulmonary Complications of Sickle Cell Disease...
inserting DNA into their host cells' genome. Many such viruses have been the basis of research using viruses in gene therapy, but the lentivirus is unique...
phage therapy would be expected to give rise to few side effects, even at higher-than-therapeutic levels. Because phages replicate in vivo (in cells of living...
therapeutic proteins and viruses for gene therapy as well as safety testing for a vast array of chemicals. HEK 293 cells were generated in 1973 by transfection...
Intravenous therapy (abbreviated as IV therapy) is a medical technique that administers fluids, medications and nutrients directly into a person's vein...
photodynamic therapy". Physics in Medicine and Biology. 53 (9): R61–R109. doi:10.1088/0031-9155/53/9/R01. PMID 18401068. S2CID 4366743. Lee, TK; ED Baron;...
select immune components can be added to immunosuppressive therapy. The monoclonal anti-T cell antibody OKT3, once used to prevent rejection, and still...
Bondanza A, Peccatori J, et al. (2015). "Improving the safety of celltherapy with the TK-suicide gene". Frontiers in Pharmacology. 6: 95. doi:10.3389/fphar...
TK inhibitor, nilotinib, was approved by the FDA for the same indication. In 2010, nilotinib and dasatinib were also approved for first-line therapy,...
compression therapy (IPC) utilizes a multi-chambered pneumatic sleeve with overlapping cells to promote movement of lymph fluid. Pump therapy should only...
in the pathogenic processes of the rheumatic joints, and therapies that target these cells are emerging as promising therapeutic tools, raising hope...
P; Atkins, MB; Stampfer, M; Choueiri, TK (2011). "Prospective Evaluation of Analgesic Use and Risk of Renal Cell Cancer". Archives of Internal Medicine...
chemotherapy, radiation therapy, or a stem cell transplant. The specific genetic mutations present within the cancer cells may guide therapy, as well as determine...
which HSK-TK assists in converting GCV to a toxic compound that inhibits DNA synthesis and causes cell death. Whereas, direct gene therapy employs a toxin...
G (June 2011). "Hematopoietic stem cell transplantation for thalassemia". Current Stem Cell Research & Therapy. 6 (2): 162–9. doi:10.2174/157488811795495413...
PMC 4078834. PMID 24927565. Starr TK, Jameson SC, Hogquist KA (2003-01-01). "Positive and negative selection of T cells". Annual Review of Immunology. 21...
photodynamic therapy, epidermal radioisotope therapy, topical chemotherapy, electrodesiccation and curettage can be found in the discussions of basal-cell carcinoma...
AM, Larkö O (February 2008). "Review of photodynamic therapy in actinic keratosis and basal cell carcinoma". Therapeutics and Clinical Risk Management...
kidney cancer". 2017-08-30. Choueiri TK, et al. (2021-08-19). "Adjuvant Pembrolizumab after Nephrectomy in Renal-Cell Carcinoma". New England Journal of...
Cengiz I, Owonikoko TK (July 2020). "Disialoganglioside GD2 Expression in Solid Tumors and Role as a Target for Cancer Therapy". Frontiers in Oncology...
Once inside the cell, the CagA protein is phosphorylated on tyrosine residues by a host cell membrane-associated tyrosine kinase (TK). CagA then allosterically...
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