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negative regulation of cell population proliferation
positive regulation of stress-activated MAPK cascade
cell-cell junction organization
extrinsic apoptotic signaling pathway
collagen fibril organization
positive regulation of epithelial cell migration
neutrophil chemotaxis
positive regulation of cell growth
response to wounding
negative regulation of cell growth
positive regulation of cardioblast differentiation
glial cell migration
wound healing
positive regulation of ossification
cardiac muscle cell proliferation
positive regulation of epithelial to mesenchymal transition
odontogenesis
positive regulation of timing of catagen
positive regulation of immune response
regulation of complement-dependent cytotoxicity
positive regulation of protein secretion
epithelial to mesenchymal transition
embryonic digestive tract development
response to hypoxia
cell-cell signaling
positive regulation of pathway-restricted SMAD protein phosphorylation
heart morphogenesis
platelet degranulation
salivary gland morphogenesis
generation of neurons
negative regulation of immune response
cell morphogenesis
positive regulation of cell population proliferation
positive regulation of phosphatidylinositol 3-kinase signaling
cell migration
activation of protein kinase activity
positive regulation of cell division
cardiac epithelial to mesenchymal transition
BMP signaling pathway
cell development
skeletal system development
kidney development
neural tube closure
hair follicle development
outflow tract septum morphogenesis
membranous septum morphogenesis
heart valve morphogenesis
atrioventricular valve morphogenesis
pulmonary valve morphogenesis
endocardial cushion morphogenesis
cardiac right ventricle morphogenesis
ventricular trabecula myocardium morphogenesis
endocardial cushion fusion
atrial septum primum morphogenesis
neural retina development
heart development
male gonad development
hemopoiesis
embryonic limb morphogenesis
hair follicle morphogenesis
ascending aorta morphogenesis
dopamine biosynthetic process
positive regulation of cell cycle
negative regulation of Ras protein signal transduction
somatic stem cell division
neuron development
inner ear development
uterus development
pathway-restricted SMAD protein phosphorylation
ventricular septum morphogenesis
atrial septum morphogenesis
pharyngeal arch artery morphogenesis
regulation of apoptotic process involved in outflow tract morphogenesis
substantia propria of cornea development
cranial skeletal system development
negative regulation of epithelial to mesenchymal transition involved in endocardial cushion formation
positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation
regulation of signaling receptor activity
negative regulation of gene expression
negative regulation of angiogenesis
positive regulation of Notch signaling pathway
SMAD protein signal transduction
positive regulation of pri-miRNA transcription by RNA polymerase II
embryo development ending in birth or egg hatching
regulation of timing of catagen
secondary palate development
regulation of cell population proliferation
regulation of apoptotic process
regulation of MAPK cascade
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
7042
21808
Ensembl
ENSG00000092969
ENSMUSG00000039239
UniProt
P61812
P27090
RefSeq (mRNA)
NM_003238 NM_001135599
NM_009367 NM_001329107
RefSeq (protein)
NP_001129071 NP_003229
NP_001316036 NP_033393
Location (UCSC)
Chr 1: 218.35 – 218.44 Mb
Chr 1: 186.35 – 186.44 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Transforming growth factor-beta 2 (TGF-β2) is a secreted protein known as a cytokine that performs many cellular functions and has a vital role during embryonic development (alternative names: Glioblastoma-derived T-cell suppressor factor, G-TSF, BSC-1 cell growth inhibitor, Polyergin, Cetermin). It is an extracellular glycosylated protein. It is known to suppress the effects of interleukin dependent T-cell tumors. There are two named isoforms of this protein, created by alternative splicing of the same gene (i.e., TGFB2).
^ abcGRCh38: Ensembl release 89: ENSG00000092969 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000039239 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Transforming growth factor-beta2 (TGF-β2) is a secreted protein known as a cytokine that performs many cellular functions and has a vital role during...
Transforming growth factor beta (TGF-β) is a multifunctional cytokine belonging to the transforming growth factor superfamily that includes three different...
Transforming growth factor, beta receptor II (70/80kDa) is a TGFbeta receptor. TGFBR2 is its human gene. It is a tumor suppressor gene. This gene encodes...
growth factor beta receptor I (activin A receptor type II-like kinase, 53kDa) is a membrane-bound TGFbeta receptor protein of the TGF-beta receptor family...
Transforming growth factor beta 1 or TGF-β1 is a polypeptide member of the transforming growth factor beta superfamily of cytokines. It is a secreted...
factor beta (TGF-β) superfamily is a large group of structurally related cell regulatory proteins that was named after its first member, TGF-β1, originally...
263 (32): 16984–91. doi:10.1016/S0021-9258(18)37487-8. PMID 2903157. TGF-beta+Receptors at the U.S. National Library of Medicine Medical Subject Headings...
Nodal and TGFβs. Signaling begins with the binding of a TGFbeta superfamily ligand to a TGFbeta type II receptor. The type II receptor is a serine/threonine...
Transforming growth factor beta (TGF-β) is a potent cell regulatory polypeptide homodimer of 25kD. It is a multifunctional signaling molecule with more...
Tokuyama Y, Tokuyama H (February 1993). "Purification and identification of TGF-beta2-related growth factor from bovine colostrum". Journal of Dairy Research...
TGF-beta superfamily of ligands via its core protein, and bFGF via its heparan sulfate chains. TGFBR3 is the most widely expressed type of TGF-beta receptor...
recruited to the TGF-beta receptors through its interaction with the SMAD anchor for receptor activation (SARA) protein. In response to TGF-beta signal, this...
factor-beta (TGF-β1) are also thought to be involved in the pathogenesis of pre-eclampsia. They belong to the transforming growth factor beta family....
type I membrane glycoprotein located on cell surfaces and is part of the TGFbeta receptor complex. It is also commonly referred to as CD105, END, FLJ41744...
dimeric cell-surface receptors composed of alpha and beta subunits, which activates TGF-β.< TGF-β is a multifunctional cytokine that modulates a variety...
gene plays an important role in the TGF-beta (transforming growth factor beta) signaling system. Because the TGF-beta system operates in nervous tissues...
is a human monoclonal antibody and an immunosuppressive drug targeting TGFbeta2. It was being developed to reduce scarring after glaucoma drainage surgery...
factor beta (TGF-β) superfamily of cytokines, which regulate cell proliferation, differentiation and death. Based on its essential role in TGFbeta signaling...
this gene belongs to the family of latent transforming growth factor (TGF)-beta binding proteins (LTBP), which are extracellular matrix proteins with...
The activin type 2 receptors belong to a larger TGF-beta receptor family and modulate signals for transforming growth factor beta ligands. These receptors...