PCAF information

KAT2B
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1CM0, 1JM4, 1N72, 1WUG, 1WUM, 1ZS5, 2RNW, 2RNX, 3GG3, 4NSQ, 5FE2, 5FE4, 5FDZ, 5FE8, 5FE5, 5FE1, 5FE7, 5FE9, 5FE3, 5FE0, 5FE6
Identifiers
Aliases	KAT2B, CAF, P/CAF, PCAF, lysine acetyltransferase 2B
External IDs	OMIM: 602303; MGI: 1343094; HomoloGene: 20834; GeneCards: KAT2B; OMA:KAT2B - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	20,154,404 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	53,979,748 bp
RNA expression pattern
	Top expressed in
	external globus pallidus; ; trabecular bone; ; buccal mucosa cell; ; corpus callosum; ; Achilles tendon; ; subthalamic nucleus; ; pars reticulata; ; amniotic fluid; ; Skeletal muscle tissue of rectus abdominis; ; Pars compacta;
	Top expressed in
	retinal pigment epithelium; ; nasal epithelium; ; olfactory epithelium; ; Epithelium of choroid plexus; ; iris; ; seminal vesicula; ; vestibular membrane of cochlear duct; ; gastrula; ; extensor digitorum longus muscle; ; ankle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity; RNA polymerase II transcription regulatory region sequence-specific DNA binding; transcription coregulator activity; protein binding; acyltransferase activity; histone acetyltransferase activity; cyclin-dependent protein serine/threonine kinase inhibitor activity; protein kinase binding; chromatin binding; lysine N-acetyltransferase activity, acting on acetyl phosphate as donor; transcription coactivator activity; transcription factor binding; histone deacetylase binding; acetyltransferase activity; protein-containing complex binding; peptide-lysine-N-acetyltransferase activity; diamine N-acetyltransferase activity;
Cellular component	I band; nucleoplasm; histone acetyltransferase complex; A band; actomyosin; kinetochore; nucleus; cytoplasm; centrosome; microtubule organizing center; cytoskeleton; protein-containing complex;
Biological process	Notch signaling pathway; regulation of protein ADP-ribosylation; epigenetic maintenance of chromatin in transcription-competent conformation; chromatin remodeling; regulation of transcription, DNA-templated; negative regulation of cyclin-dependent protein serine/threonine kinase activity; rhythmic process; N-terminal peptidyl-lysine acetylation; transcription, DNA-templated; positive regulation of transcription, DNA-templated; histone acetylation; histone H3 acetylation; cellular response to insulin stimulus; histone H3-K9 acetylation; cell cycle; transcription initiation from RNA polymerase II promoter; viral process; peptidyl-lysine acetylation; negative regulation of cell population proliferation; positive regulation of transcription by RNA polymerase II; internal peptidyl-lysine acetylation; regulation of megakaryocyte differentiation; protein acetylation; positive regulation of transcription of Notch receptor target; heart development; positive regulation of Notch signaling pathway; negative regulation of centriole replication; limb development; protein deubiquitination;
	Sources:Amigo / QuickGO
Orthologs
	8850
	18519
	ENSG00000114166
	ENSMUSG00000000708
	Q92831
	Q9JHD1
	NM_003884
	NM_001190846; NM_020005
	NP_003875
	NP_001177775; NP_064389
	Wikidata
View/Edit Human	View/Edit Mouse

P300/CBP-associated factor (PCAF), also known as K(lysine) acetyltransferase 2B (KAT2B), is a human gene and transcriptional coactivator associated with p53.

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000114166 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000000708 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000114166 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000000708 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

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