Protein-coding gene in the species Homo sapiens
LMX1A Identifiers Aliases LMX1A , LMX1, LMX1.1, LIM homeobox transcription factor 1 alpha, DFNA7External IDs OMIM: 600298; MGI: 1888519; HomoloGene: 24921; GeneCards: LMX1A; OMA:LMX1A - orthologs Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q23.3 Start 165,201,867 bp[1] End 165,356,715 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1 H2.3|1 75.08 cM Start 167,516,806 bp[2] End 167,676,310 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in testicle apex of heart muscle of thigh pituitary gland anterior pituitary gastric mucosa left testis rectum right testis subcutaneous adipose tissue
Top expressed in choroid plexus of lateral ventricle choroid plexus of fourth ventricle otic vesicle notochord yolk sac Neural groove zygote neural fold extraocular muscle Neurogenic placodes
More reference expression data
BioGPS
Gene ontology Molecular function
protein binding
DNA binding
sequence-specific DNA binding
metal ion binding
RNA polymerase II transcription regulatory region sequence-specific DNA binding
DNA-binding transcription activator activity, RNA polymerase II-specific
DNA-binding transcription factor activity, RNA polymerase II-specific
Cellular component Biological process
neuron differentiation
cerebellum development
multicellular organism development
midbrain development
central nervous system development
regulation of transcription, DNA-templated
axon guidance
dentate gyrus development
transcription, DNA-templated
negative regulation of neuron differentiation
central nervous system neuron differentiation
hippocampus development
regulation of cell growth
brain development
dopaminergic neuron differentiation
regulation of gene expression
positive regulation of transcription by RNA polymerase II
synapse organization
olfactory behavior
memory
locomotory behavior
midbrain dopaminergic neuron differentiation
transcription by RNA polymerase II
Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez Ensembl UniProt RefSeq (mRNA) NM_001033507 NM_001174069 NM_177398 NM_177399
RefSeq (protein) Location (UCSC) Chr 1: 165.2 – 165.36 Mb Chr 1: 167.52 – 167.68 Mb PubMed search [3] [4]
Wikidata View/Edit Human View/Edit Mouse
LIM homeobox transcription factor 1, alpha , also known as LMX1A , is a protein which in humans is encoded by the LMX1A gene.[5] [6]
^ a b c GRCh38: Ensembl release 89: ENSG00000162761 – Ensembl, May 2017
^ a b c GRCm38: Ensembl release 89: ENSMUSG00000026686 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine .
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine .
^ "Entrez Gene: LMX1A LIM homeobox transcription factor 1, alpha".
^ German MS, Wang J, Fernald AA, Espinosa R, Le Beau MM, Bell GI (November 1994). "Localization of the genes encoding two transcription factors, LMX1 and CDX3, regulating insulin gene expression to human chromosomes 1 and 13". Genomics . 24 (2): 403–4. doi:10.1006/geno.1994.1639. PMID 7698771.
Last Update: 2022-03-30T16:26:33Z
transcription factor 1, alpha, also known as LMX1A , is a protein which in humans is encoded by the LMX1A gene. Insulin is produced exclusively by the...
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Last Update: 2023-09-23T02:10:54Z
Inferred motif from similar protein – High-throughput in vitro [496] RTTYAAAH LMX1A ENSG00000162761 Homeodomain Known motif – High-throughput in vitro [497]...
Word Count : 81
Last Update: 2024-04-01T17:00:44Z
LIM-class: ISL1, ISL2; LHX1, LHX2, LHX3, LHX4, LHX5, LHX6, LHX8, LHX9; LMX1A , LMX1B POU-class: HDX; POU1F1; POU2F1; POU2F2; POU2F3; POU3F1; POU3F2; POU3F3;...
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Last Update: 2024-01-18T05:05:10Z
has been shown to interact with: CBFA2T3, CREBBP, ELK3, EP300, ID3, LDB1, LMX1A , LYL1, MAPKAPK3, MyoD, Myogenin, PCAF, TAL1 TWIST1, and UBE2I. GRCh38: Ensembl...
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Last Update: 2023-12-02T19:29:25Z
Westberg L, et al. (2009). "Do polymorphisms in transcription factors LMX1A and LMX1B influence the risk for Parkinson's disease?". J Neural Transm...
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Last Update: 2024-05-22T03:17:17Z
binding factor sites, some of these binding factors include GATA1, TGIF, LMX1A , and NKX61 There are no known micro-RNA targets in the 3' UTR. mRNA secondary...
Word Count : 1397
Last Update: 2024-04-09T19:38:23Z
Insulin promoter factor 1; pancreatic and duodenal homeobox 1 (Pdx1) 0.924 + LMX1A LIM homeobox transcription factor 1 alpha 1.0 + NACA Nascent polypeptide-associated...
Word Count : 1690