Systemic administration is a route of administration of medication, nutrition or other substance into the circulatory system so that the entire body is affected.[1] Administration can take place via enteral administration (absorption of the drug through the gastrointestinal tract)[2] or parenteral administration (generally injection, infusion, or implantation).[3][4]
Contrast with topical administration where the effect is generally local.[4]
^Hunnius Pharmazeutisches Wörterbuch (in German) (8th ed.). Berlin: Walter de Gruyter. 1998. p. 1477. ISBN 3-11-015793-4.
^"Enteral administration - pharmacology". britannica.com. Retrieved 19 April 2018.
^Hunnius Pharmazeutisches Wörterbuch (in German) (8th ed.). Berlin: Walter de Gruyter. 1998. pp. 472, 1029. ISBN 3-11-015793-4.
^ abMutschler, Ernst (2013). Arzneimittelwirkungen (in German) (10 ed.). Stuttgart: Wissenschaftliche Verlagsgesellschaft. p. 8. ISBN 978-3-8047-2898-1.
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Systemicadministration is a route of administration of medication, nutrition or other substance into the circulatory system so that the entire body is...
either topical administration or systemicadministration, as the drugs thus locally delivered can go on to have either purely local or systemic effects ibuprofen...
gastrointestinal tract), or parenteral (systemic action, but is delivered by routes other than the GI tract). Route of administration and dosage form are aspects...
medicine, systemic means affecting the whole body, or at least multiple organ systems. It is in contrast with topical or local. Systemicadministration, a route...
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the first-pass metabolism as the rectum's venous drainage is two-thirds systemic (middle and inferior rectal vein) and one-third hepatic portal system (superior...
medical source?] Many pharmaceutical drugs exist as nasal sprays for systemicadministration (e.g. sedative-analgesics, treatments for migraine, osteoporosis...
occur as a result of inhibition of the enzymes. Ciprofloxacin for systemicadministration is available as immediate-release tablets, extended-release tablets...
amphetamine is the predominant pathway of metabolism. Following systemicadministration of amphetamine to rats, POH has been found in urine and in plasma...
amphetamine is the predominant pathway of metabolism. Following systemicadministration of amphetamine to rats, POH has been found in urine and in plasma...
The cause of the syndrome may be drug-related: i.e., induced by systemicadministration of hydroxyzine, penicillin, iodinated radio contrast media, and...
amphetamine is the predominant pathway of metabolism. Following systemicadministration of amphetamine to rats, POH has been found in urine and in plasma...
the CNS more effectively than systemicadministration, potentially improving therapeutic outcomes and reducing systemic side effects. Advances in this...
amphetamine is the predominant pathway of metabolism. Following systemicadministration of amphetamine to rats, POH has been found in urine and in plasma...
counseling, such as psychotherapy (see also: list of psychotherapies) systemic therapy by group psychotherapy by cognitive behavioral therapy by cognitive...
amphetamine is the predominant pathway of metabolism. Following systemicadministration of amphetamine to rats, POH has been found in urine and in plasma...
In immunology, systemic inflammatory response syndrome (SIRS) is an inflammatory state affecting the whole body. It is the body's response to an infectious...
vaginal portion of cervix) with limited systemic adverse effects compared to other routes of administration. Formulation methods include vaginal tablets...
adverse effects of dark sulfonated shale oil following local and systemicadministration]". Arzneimittel-Forschung (in German). 44 (7): 844–849. PMID 7945520...
Blum L, Takano T, Tian GF, Goldman SA, Nedergaard M (July 2009). "Systemicadministration of an antagonist of the ATP-sensitive receptor P2X7 improves recovery...
Transdermal is a route of administration wherein active ingredients are delivered across the skin for systemic distribution. Examples include transdermal...
after surgery in place of systemic analgesia is less likely to decrease intestinal motility which would occur with systemic opioid therapy through blockade...
amphetamine is the predominant pathway of metabolism. Following systemicadministration of amphetamine to rats, POH has been found in urine and in plasma...
localized disease generally have a normal life expectancy. In those with systemic disease, life expectancy can be affected, and this varies based on subtype...
"Cross-reactivity between nickel and palladium demonstrated by systemicadministration of nickel". Contact Dermatitis. 53 (1): 2–8. doi:10.1111/j.0105-1873...
, with more than 114 million prescriptions. Levothyroxine for systemicadministration is available as an oral tablet, an intramuscular injection, and...
Systemic scleroderma, or systemic sclerosis, is an autoimmune rheumatic disease characterised by excessive production and accumulation of collagen, called...
in the lab or after reaching the site of injury (via local or systemicadministration). These cells then integrate into the site of injury, replacing...
by enteral administration may be subjected to significant first pass metabolism, and therefore, the amount of drug entering the systemic circulation...
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