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Chemical compound
Phenylacetone, also known as phenyl-2-propanone, is an organic compound with the chemical formula C6H5CH2COCH3. It is a colorless oil that is soluble in organic solvents. It is a mono-substituted benzene derivative, consisting of an acetone attached to a phenyl group. As such, its systematic IUPAC name is 1-phenyl-2-propanone.
This substance is used in the manufacture of methamphetamine and amphetamine, where it is commonly known as P2P.[2][3] Due to illicit drug labs using phenylacetone to make amphetamines, phenylacetone was declared a schedule II controlled substance in the United States in 1980.[4] In humans, phenylacetone occurs as a metabolite of amphetamine and methamphetamine via FMO3-mediated oxidative deamination.[5]
^Anvisa (31 March 2023). "RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). Diário Oficial da União (published 4 April 2023). Archived from the original on 3 August 2023. Retrieved 15 August 2023.
^Toske, Steven G.; Brown, Jaclyn L.; Miller, Erin E.; Phillips, Monica Z.; Kerr, Susan C.; Hays, Patrick A. (1 May 2019). "Recent methamphetamine profiling trends: Tracking the nitrostyrene method used for P2P production". Forensic Chemistry. 13: 100140. doi:10.1016/j.forc.2018.12.003. ISSN 2468-1709. S2CID 104413528.
^"Synthesis of Phenyl-2-Propanone (P2P) - [www.rhodium.ws]". erowid.org. Retrieved 15 April 2023.
^"Schedules of Controlled Substances; Schedule II Placement of Phenylacetone; (Phenyl-2-propanone, P2P, methyl benzyl ketone, benzyl methyl ketone)" (PDF). Isomer Design. Drug Enforcement Administration. 11 February 1980. Archived (PDF) from the original on 3 March 2022. Retrieved 16 January 2023.
^Cashman, John R.; Xiong, Yeng N.; Xu, Lifen; Janowsky, Aaron (1 March 1999). "N-Oxygenation of Amphetamine and Methamphetamine by the Human Flavin-Containing Monooxygenase (Form 3): Role in Bioactivation and Detoxication". Journal of Pharmacology and Experimental Therapeutics. 288 (3): 1251–1260. ISSN 0022-3565. PMID 10027866.
Phenylacetone, also known as phenyl-2-propanone, is an organic compound with the chemical formula C6H5CH2COCH3. It is a colorless oil that is soluble...
Phenylacetones are a group of organic compounds containing a phenyl moiety and an acetone moiety bonded together, the archetypal example being phenylacetone...
commercial chemical, because it can be used in the illicit production of phenylacetone (used in the manufacture of substituted amphetamines), it is subject...
In enzymology, a phenylacetone monooxygenase (EC 1.14.13.92) is an enzyme that catalyzes the chemical reaction phenylacetone + NADPH + H+ + O2 ⇌ {\displaystyle...
starting from phenylacetone by either the Leuckart or reductive amination methods. In the Leuckart reaction, one equivalent of phenylacetone is reacted with...
application architecture in computing or networking List of P2P protocols Phenylacetone, an organic compound commonly known as P2P Point-to-point (telecommunications)...
4-hydroxyphenylacetone, benzoic acid, hippuric acid, norephedrine, and phenylacetone. Among these metabolites, the active sympathomimetics are 4-hydroxyamphetamine...
enough to remove the proton irreversibly. For example, in the case of phenylacetone, deprotonation can produce two different enolates. LDA has been shown...
methylamine. On the show, the phenyl-2-propanone (otherwise known as phenylacetone or P2P) is produced from phenylacetic acid and acetic acid using a tube...
organic compound. Cyclohexylacetone is closely related to phenylacetone being phenylacetone with the benzene ring replaced with a cyclohexane ring. Cyclohexylacetone...
4-hydroxyphenylacetone, benzoic acid, hippuric acid, norephedrine, and phenylacetone. Among these metabolites, the active sympathomimetics are 4-hydroxyamphetamine...
and its salts, optical isomers, and salts of optical isomers (APAAN) phenylacetone, methamphetamine, amphetamine Anthranilic acid, its esters, and its...
Charles D.; Thomas, Charles L. (1936). "Preparation of Dibenzyl Ketone and Phenylacetone". J. Am. Chem. Soc. 58 (7): 1240. doi:10.1021/ja01298a043. v t e...
Chavicol Chromane Cinnamyl alcohol 4-Ethylbenzaldehyde Hydrocinnamaldehyde Phenylacetone Propiophenone 4-Vinylanisole This set index page lists chemical structure...
carried out in three steps. For amphetamine synthesis, a mixture of phenylacetone and formamide (sometimes in the presence of formic acid) or ammonium...
4-hydroxyphenylacetone, benzoic acid, hippuric acid, norephedrine, and phenylacetone. Among these metabolites, the active sympathomimetics are 4-hydroxyamphetamine...
Balamuralikrishna, a Carnatic musician Benzyl methyl ketone, synonymous of phenylacetone Brian Kibler, full name Brian McCormick Kibler Bare metal kernel, an...
4-hydroxyphenylacetone, benzoic acid, hippuric acid, norephedrine, and phenylacetone. Among these metabolites, the active sympathomimetics are 4-hydroxyamphetamine...
production in the United States occurred in small independent laboratories. Phenylacetone, one precursor of methamphetamine, became a Schedule II controlled immediate...
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