Three different views of the high resolution structure of a truncated neuronal SNARE complex. Legend: synaptobrevin-2 (red), Syntaxin-1 (pink), SNAP-25 (purple).
Identifiers
Symbol
Synaptobrevin
Pfam
PF00957
InterPro
IPR016444
PROSITE
PDOC00368
SCOP2
1sfc / SCOPe / SUPFAM
OPM superfamily
197
OPM protein
4wy4
Membranome
351
Available protein structures:
Pfam
structures / ECOD
PDB
RCSB PDB; PDBe; PDBj
PDBsum
structure summary
Synaptobrevins (synaptobrevin isotypes 1-2) are small integral membrane proteins of secretory vesicles with molecular weight of 18 kilodalton (kDa) that are part of the vesicle-associated membrane protein (VAMP) family.[1][2][3][4][5]
Synaptobrevin is one of the SNARE proteins involved in formation of the SNARE complexes.
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Baumert M, Maycox PR, Navone F, De Camilli P, Jahn R (February 1, 1989). "Synaptobrevin: an integral membrane protein of 18,000 daltons present in small synaptic vesicles of rat brain". EMBO J. 8 (2): 379–84. doi:10.1002/j.1460-2075.1989.tb03388.x. PMC 400817. PMID 2498078.
Synaptobrevins (synaptobrevin isotypes 1-2) are small integral membrane proteins of secretory vesicles with molecular weight of 18 kilodalton (kDa) that...
layer in the assembled core SNARE complex. One particular R-SNARE is synaptobrevin, which is located in the synaptic vesicles. Q-SNAREs are proteins that...
light chain is then free to cleave the Gln76-Phe77 bond of synaptobrevin. Cleavage of synaptobrevin affects the stability of the SNARE core by restricting...
2 (VAMP2) is a protein that in humans is encoded by the VAMP2 gene. Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein SNAP25...
docking of synaptic vesicles in an ATP-dependent manner. With the help of synaptobrevin on the synaptic vesicle, the t-SNARE complex on the membrane, made up...
of a vesicle with the cell membrane to initiate an exocytotic event. Synaptobrevin, a protein that is a part of the vesicle-associated membrane protein...
SNAP-25 and syntaxin-1, which later accommodates synaptobrevin-2 (the quoted syntaxin and synaptobrevin isotypes participate in neuronal neuromediator release)...
have two transmembrane domains. The SNARE (H3) domain binds to both synaptobrevin and SNAP-25 forming the core SNARE complex. Formation of this stable...
cytosol, where it cleaves vesicle associated membrane protein (VAMP) synaptobrevin, which is necessary for membrane fusion of small synaptic vesicles (SSV's)...
syntaxin 1, SNAP-25 (synaptosome associated protein, 25kDa), and VAMP (synaptobrevin). These proteins contain transmembrane regions that can be found in...
membrane protein 5 (VAMP-5) is a synaptobrevin protein encoded in the human by the VAMP5 gene. VAMPs (synaptobrevins) along with syntaxins and the 25-kD...
exocytosis by promoting interaction between the complementary syntaxin and synaptobrevin transmembrane regions that reside in opposing membranes prior to fusion...
rapid change in pH upon synaptic vesicle fusion, pHluorins tagged to synaptobrevin have been used to visualize synaptic activity in neurons. Redox sensitive...
is a protein that in humans is encoded by the SNPH gene. Syntaxin-1, synaptobrevin/VAMP, and SNAP25 interact to form the SNARE complex, which is required...
example, an R-SNARE not normally found in synapses can substitute for synaptobrevin. The Spätzle protein is a ligand of Toll. In addition to melanin's more...
syntaxin Located on the synaptic membrane and binds to SNAP-25 and synaptobrevin to mediate vesicle fusion. Cytoskeletal Proteins Actin Tubulin myosin...
is unknown: it interacts with the essential synaptic vesicle protein synaptobrevin, but when the synaptophysin gene is experimentally inactivated in animals...
proteins Sp1 and zif268/egr-1 in transcriptional regulation of the human synaptobrevin II gene". European Journal of Biochemistry. 239 (3): 827–34. doi:10...
Chawla A, Roche PA (June 1996). "Identification of a novel syntaxin- and synaptobrevin/VAMP-binding protein, SNAP-23, expressed in non-neuronal tissues". The...
bundle formed by 4 alpha-helical proteins, including vesicle-associated synaptobrevin and cell-membrane-associated syntaxin and SNAP. When the bundle is viewed...
Complex found in the target membrane. The SNARE complex reacts with synaptobrevin found on the vesicle membrane. This forces the vesicle membrane against...
PY, Adachi M, Kavalali ET (2018) Behavioral analysis of SNAP-25 and Synaptobrevin-2 haploinsufficiency in mice. Neuroscience, in press. Horvath PM, Monteggia...
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