synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex
voltage-gated potassium channel complex
plasma membrane
synapse
synaptic vesicle membrane
secretory granule
extracellular region
synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex
cell junction
SNARE complex
intracellular organelle
neuron projection
synaptobrevin 2-SNAP-25-syntaxin-1a complex
actomyosin
cytoplasmic vesicle
presynaptic membrane
postsynaptic density
presynaptic active zone membrane
nuclear membrane
integral component of plasma membrane
axon
protein-containing complex
acrosomal vesicle
integral component of synaptic vesicle membrane
glutamatergic synapse
integral component of presynaptic membrane
endomembrane system
intracellular anatomical structure
Biological process
exocytosis
positive regulation of norepinephrine secretion
synaptic vesicle docking
secretion by cell
regulation of insulin secretion
positive regulation of catecholamine secretion
positive regulation of neurotransmitter secretion
positive regulation of calcium ion-dependent exocytosis
regulation of exocytosis
response to gravity
vesicle docking
positive regulation of excitatory postsynaptic potential
positive regulation of exocytosis
intracellular protein transport
neurotransmitter transport
vesicle-mediated transport
calcium-ion regulated exocytosis
regulation of synaptic vesicle priming
protein localization to membrane
modulation of excitatory postsynaptic potential
synaptic vesicle fusion to presynaptic active zone membrane
SNARE complex assembly
cytokine-mediated signaling pathway
synaptic vesicle exocytosis
vesicle fusion
neurotransmitter secretion
glutamate secretion
protein sumoylation
insulin secretion
regulated exocytosis
hormone secretion
synaptic vesicle endocytosis
membrane fusion
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
6804
20907
Ensembl
ENSG00000106089
ENSMUSG00000007207
UniProt
Q16623 Q75ME0
O35526
RefSeq (mRNA)
NM_001165903 NM_004603
NM_016801 NM_001359179
RefSeq (protein)
NP_001159375 NP_004594 NP_004594.1
NP_058081 NP_001346108
Location (UCSC)
Chr 7: 73.7 – 73.72 Mb
Chr 5: 135.05 – 135.08 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Syntaxin-1A is a protein that in humans is encoded by the STX1A gene.[5]
^ abcGRCh38: Ensembl release 89: ENSG00000106089 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000007207 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Bennett MK, Calakos N, Scheller RH (July 1992). "Syntaxin: a synaptic protein implicated in docking of synaptic vesicles at presynaptic active zones". Science. 257 (5067): 255–9. Bibcode:1992Sci...257..255B. doi:10.1126/science.1321498. PMID 1321498.
Syntaxin-1A is a protein that in humans is encoded by the STX1A gene. Synaptic vesicles store neurotransmitters that are released during calcium-regulated...
chromosome. They cite mutations in the brain-related genes timeless, FoxP2, and STX1A, and perhaps others as underlying Cono 7Q's ability to perceive high-speed...
roles of Munc18-1 rely on distinct binding modes of the central cavity with Stx1A and SNARE complex". Molecular Biology of the Cell. 22 (21): 4150–60. doi:10...
with: DNAJC5, GOPC, PDZK1, PRKCE, SLC4A8, SNAP23, SLC9A3R1, SLC9A3R2, and STX1A, It is inhibited by the anti-diarrhoea drug crofelemer. Congenital bilateral...
brain to modulate blood pressure. SLC6A1 has been shown to interact with STX1A. Solute carrier family GABA transporter 2 GABA transporter 3 SLC6A1 epileptic...
protein binds SYTL4. STXBP1 has been shown to interact with STX2, STX4 and STX1A. GRCh38: Ensembl release 89: ENSG00000136854 – Ensembl, May 2017 GRCm38:...
transmitter release. CPLX1 has been shown to interact with SNAP-25 and STX1A. GRCh38: Ensembl release 89: ENSG00000168993 – Ensembl, May 2017 GRCm38:...
movements). VAMP2 has been shown to interact with: RABAC1, SNAP-25, SNAP23, STX1A, and STX4. GRCh38: Ensembl release 89: ENSG00000220205 – Ensembl, May 2017...
has been shown to interact with: CPLX1, ITSN1, KIF5B, SNAPAP and STX11, STX1A, STX2, STX4, SYT1, Syntaxin 3, TRIM9, and VAMP2. Synaptotagmin binds SNAP-25...
response to phorbol ester binding. UNC13A has been shown to interact with: STX1A, STX1B1, DOC2A, BSN, RIMS1, RIMS2, ERC2, and RAB3A. Single nucleotide polymorphisms...
neurotransmitter release machinery. RNF40 has been shown to interact with STX1A. GRCh38: Ensembl release 89: ENSG00000103549 – Ensembl, May 2017 GRCm38:...
complex to open fusion pores. SYT1 has been shown to interact with SNAP-25, STX1A and S100A13. Mutations in the SYT1 gene cause a rare neurodevelopmental...
exocytosis. UNC13B has been shown to interact with: DOC2A, RIMS1, SPTBN2, STX1A, and STX1B. GRCh38: Ensembl release 89: ENSG00000198722 – Ensembl, May 2017...
domain seen in the infobox. STXBP5 has been shown to interact with STX4 and STX1A. GRCh38: Ensembl release 89: ENSG00000164506 – Ensembl, May 2017 GRCm38:...
that causes hypertension. SCNN1G has been shown to interact with: NEDD4, STX1A, and Ubiquitin C Epithelial sodium channel GRCh38: Ensembl release 89: ENSG00000166828...
Global Information
