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Subthalamic nucleus information


Subthalamic nucleus
Coronal slices of human brain showing the basal ganglia (external globus pallidus (GPe) and internal globus pallidus (GPi)), subthalamic nucleus (STN) and substantia nigra (SN).
DA-loops in Parkinson's disease
Details
Part ofSubthalamus (physically); basal ganglia (functionally)
Identifiers
Latinnucleus subthalamicus
Acronym(s)STN
MeSHD020531
NeuroNames435
NeuroLex IDnlx_anat_1010002
TA98A14.1.08.702
TA25709
FMA62035
Anatomical terms of neuroanatomy
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The subthalamic nucleus (STN) is a small lens-shaped nucleus in the brain where it is, from a functional point of view, part of the basal ganglia system. In terms of anatomy, it is the major part of the subthalamus. As suggested by its name, the subthalamic nucleus is located ventral to the thalamus. It is also dorsal to the substantia nigra and medial to the internal capsule. It was first described by Jules Bernard Luys in 1865,[1] and the term corpus Luysi or Luys' body is still sometimes used.

  1. ^ Luys JB (1865). Recherches sur le système cérébro-spinal, sa structure, ses fonctions et ses maladies (in French). Paris: Baillière.

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Subthalamic nucleus

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The subthalamic nucleus (STN) is a small lens-shaped nucleus in the brain where it is, from a functional point of view, part of the basal ganglia system...

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Basal ganglia

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globus pallidus, the ventral pallidum, the substantia nigra, and the subthalamic nucleus. Each of these components has complex internal anatomical and neurochemical...

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Hemiballismus

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hemiballism is a basal ganglia syndrome resulting from damage to the subthalamic nucleus in the basal ganglia. Hemiballismus is a rare hyperkinetic movement...

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Primate basal ganglia

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primate basal ganglia can be divided into striatal, pallidal, nigral, and subthalamic components. In primates, however, there are two pallidal subdivisions...

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Deep brain stimulation

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These are the globus pallidus internus, thalamus, subthalamic nucleus and the pedunculopontine nucleus. However, most DBS surgeries in routine practice...

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Substantia nigra

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projection from the globus pallidus to the subthalamic nucleus, and a glutamatergic projection from the subthalamic nucleus to the pars reticulata.[better source needed]...

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Dopaminergic pathways

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→ Hippocampus VTA → Cingulate cortex VTA → Olfactory bulb SNc → Subthalamic nucleus The mesocorticolimbic system (mesocorticolimbic circuit) refers to...

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Striatum

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receives afferents from other elements of the basal ganglia such as the subthalamic nucleus (glutamatergic) or the external globus pallidus (GABAergic). The...

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Subthalamus

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most prominent structure is the subthalamic nucleus. The subthalamus connects to the globus pallidus, a basal nucleus of the telencephalon. The subthalamus...

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Pedunculopontine nucleus

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in the brain, particularly parts of the basal ganglia such as the subthalamic nucleus, substantia nigra pars compacta, and globus pallidus internus. It...

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Internal globus pallidus

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Edinger's comb system then arrives at the laterosuperior corner of the subthalamic nucleus and constitutes the field H2 of Forel, then H, and suddenly changes...

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Executive functions

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sufficient for executive functions; for example, the caudate nucleus and subthalamic nucleus also have a role in mediating inhibitory control. Cognitive...

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Basal ganglia disease

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(composed of the putamen and caudate nucleus), globus pallidus, substantia nigra, and the subthalamic nucleus. Along with other structures, the basal...

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External globus pallidus

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neurons, allow for its inhibitory function and projects axons to the subthalamic nucleus (in the diencephalon), the striatum, internal globus pallidus (GPi)...

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Hypokinesia

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ganglia send GABA to the globus pallidus which then sends it to the subthalamic nucleus, which then disinhibited sends glutamate to the output structures...

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Nigrostriatal pathway

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axons send axon collaterals to the pedunculopontine nucleus, ventral pallidum, subthalamic nucleus, globus pallidus, amygdala, and thalamus. A small number...

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Putamen

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ganglia include the dorsal striatum, substantia nigra, nucleus accumbens, and the subthalamic nucleus. In mammals, the basal ganglia are associated with motor...

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Jules Bernard Luys

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traced the projection from the subthalamic nucleus to the globus pallidus and the projection to the subthalamic nucleus from the cerebral cortex. Today...

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Indirect pathway

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pallidus, which are parts of the basal ganglia. It traverses the subthalamic nucleus, a part of the diencephalon, and enters the substantia nigra, a part...

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Globus pallidus

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globus pallidus, and one internal, known in rodents as the entopeduncular nucleus. It is part of the telencephalon, but retains close functional ties with...

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Reward system

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(particularly, the orexinergic nucleus in the lateral hypothalamus), thalamus (multiple nuclei), subthalamic nucleus, globus pallidus (both external...

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Mahlon DeLong

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basal ganglia called the subthalamic nucleus were firing excessively, and that destroying (ablating) the subthalamic nucleus greatly improved the symptoms...

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Human brain

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multiple areas of the prefrontal cortex, as well as the caudate nucleus and subthalamic nucleus. Brain activity is made possible by the interconnections of...

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Mania

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cerebral lesions in the right hemisphere. Deep brain stimulation of the subthalamic nucleus in Parkinson's disease has been associated with mania, especially...

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Thalamotomy

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dysrhythmia. Subthalamotomy is a type of brain surgery in which the subthalamic nucleus is destroyed in attempt to help alleviate movement disorders often...

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Subthalamic fasciculus

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The subthalamic fasciculus is a bi-directional nerve tract that connects the subthalamic nucleus and the globus pallidus. DeJong, Russell N.; Campbell...

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Inhibitory control

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use of inhibitory control. The prefrontal cortex, caudate nucleus, and subthalamic nucleus are known to regulate inhibitory control cognition. Inhibitory...

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Hyperkinesia

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contractions of their mouth muscles. Typically caused by damage to the subthalamic nucleus or nuclei, hemiballismus movements are nonrhythmic, rapid, nonsuppressible...

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