TOE1 information

TOE1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2FC6
Identifiers
Aliases	TOE1, hCaf1z, target of EGR1, member 1 (nuclear), PCH7, target of EGR1, exonuclease, TOE-1
External IDs	OMIM: 613931; MGI: 1915526; HomoloGene: 11823; GeneCards: TOE1; OMA:TOE1 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	45,343,973 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	116,664,837 bp
RNA expression pattern
	Top expressed in
	olfactory bulb; ; gonad; ; parotid gland; ; mucosa of transverse colon; ; right lobe of thyroid gland; ; left testis; ; granulocyte; ; right testis; ; smooth muscle tissue; ; rectum;
	Top expressed in
	primitive streak; ; renal corpuscle; ; morula; ; blastocyst; ; spermatocyte; ; epiblast; ; superior cervical ganglion; ; medullary collecting duct; ; seminal vesicula; ; ureter;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	3'-5'-exoribonuclease activity; protein binding; metal ion binding; nucleic acid binding; poly(A)-specific ribonuclease activity; snRNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	cytoplasm; Cajal body; nuclear speck; nucleolus; nucleoplasm; nucleus; nuclear body;
Biological process	RNA phosphodiester bond hydrolysis, exonucleolytic; snRNA 3'-end processing; regulation of transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
	114034
	68276
	ENSG00000132773
	ENSMUSG00000028688
	Q96GM8
	Q9D2E2
	NM_025077
	NM_026654
	NP_079353
	NP_080930
	Wikidata
View/Edit Human	View/Edit Mouse

Target of EGR1 protein 1 is a protein that in humans is encoded by the TOE1 gene.^[5]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000132773 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000028688 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ De Belle I, Wu JX, Sperandio S, Mercola D, Adamson ED (Apr 2003). "In vivo cloning and characterization of a new growth suppressor protein TOE1 as a direct target gene of Egr1". J Biol Chem. 278 (16): 14306–12. doi:10.1074/jbc.M210502200. PMID 12562764.
^ "Entrez Gene: TOE1 target of EGR1, member 1 (nuclear)".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000132773 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000028688 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12562764-5] De Belle I, Wu JX, Sperandio S, Mercola D, Adamson ED (Apr 2003). "In vivo cloning and characterization of a new growth suppressor protein TOE1 as a direct target gene of Egr1". J Biol Chem. 278 (16): 14306–12. doi:10.1074/jbc.M210502200. PMID 12562764.

[entrez-6] "Entrez Gene: TOE1 target of EGR1, member 1 (nuclear)".

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