Sphingosine kinase (SphK) is a conserved lipid kinase that catalyzes formation sphingosine-1-phosphate (S1P) from the precursor sphingolipid sphingosine. Sphingolipid metabolites, such as ceramide, sphingosine and sphingosine-1-phosphate, are lipid second messengers involved in diverse cellular processes. There are two forms of SphK, SphK1 and SphK2. SphK1 is found in the cytosol of eukaryotic cells, and migrates to the plasma membrane upon activation. SphK2 is localized to the nucleus.
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Sphingosinekinase (SphK) is a conserved lipid kinase that catalyzes formation sphingosine-1-phosphate (S1P) from the precursor sphingolipid sphingosine...
important phospholipid. Sphingosine can be phosphorylated in vivo via two kinases, sphingosinekinase type 1 and sphingosinekinase type 2. This leads to...
coordinated for this purpose. Sphingosinekinase (SK) is a lipid kinase that catalyzes the conversion of sphingosine to sphingosine-1-phosphate (S1P). Sphingolipids...
Sphingosinekinase 2 is a protein that in humans is encoded by the SPHK2 gene. This gene encodes one of two sphingosinekinase isozymes that catalyze the...
Sphingosinekinase 1 is an enzyme that in humans is encoded by the SPHK1 gene. Sphingosinekinase 1 phosphorylates sphingosine to sphingosine-1-phosphate...
the formation of sphingosine, Moreover, a phosphate group can be attached to ceramide (phosphorylation) by the enzyme, ceramide kinase. It is also possible...
structural analogue of sphingosine and is phosphorylated by sphingosinekinases in the cell (most importantly sphingosinekinase 2). The molecular biology...
sphingoid bases, which are a set of aliphatic amino alcohols that includes sphingosine. They were discovered in brain extracts in the 1870s and were named after...
Ceramides are a family of waxy lipid molecules. A ceramide is composed of sphingosine and a fatty acid joined by an amide bond. Ceramides are found in high...
lipid, recruiting cytosolic proteins to appropriate membranes (e.g., sphingosinekinase 1). PA plays very important role in phototransduction in Drosophila...
that is used for the treatment of ulcerative colitis. It is a selective sphingosine-1-phosphate (S1P) receptor modulator that modifies the activity of the...
acids from ceramide, producing sphingosine (SPH) which in turn is phosphorylated by a sphingosinekinase to form sphingosine-1-phosphate (S1P). Ceramide...
Siponimod, sold under the brand name Mayzent, is a selective sphingosine-1-phosphate receptor modulator for oral use that is used for multiple sclerosis...
muscle contraction. When transmural pressure increases, sphingosinekinase 1 phosphorylates sphingosine to S1P, which binds to the S1P2 receptor in plasma...
Opaganib (ABC294640) is a drug which acts as an inhibitor of the enzyme sphingosinekinase 2. It is under development as a potential treatment agent for several...
have dinner with a group of her scientist friends who speculate that sphingosinekinase could lead to a cure for cancer. As a result, the President demands...
of relapsing multiple sclerosis and ulcerative colitis. It acts as a sphingosine-1-phosphate receptor (S1PR) agonist, sequestering lymphocytes to peripheral...
sequence homology with sphingosinekinase type I, including an N-terminal pleckstrin homology (PH) domain and a diacylglycerol kinase domain. BLAST searches...
EA, Gomez S, Jaspers I, Allbritton NL (April 2015). "Analysis of sphingosinekinase activity in single natural killer cells from peripheral blood". Integrative...
inducing PAR-1 dependent sphingosinekinase-1 activation and up-regulating sphingosine-1-phosphate with sphingosinekinase.: 3165 Several studies have...
several kinases, phospholipases, and synaptic proteins. For instance, while associated with actin, it can activate phosphatidylinositol 4-kinase, which...
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