Fingolimod, sold under the brand name Gilenya, is an immunomodulating medication, used for the treatment of multiple sclerosis.[3] Fingolimod is a sphingosine-1-phosphate receptor modulator, which sequesters lymphocytes in lymph nodes, preventing them from contributing to an autoimmune reaction. It has been reported to reduce the rate of relapses in relapsing-remitting multiple sclerosis by approximately one-half over a two-year period.[4]
^"FINGOLIMOD-TEVA/TE-FINGOLIMOD (Teva Pharma Australia Pty Ltd)". Therapeutic Goods Administration (TGA). 16 February 2023. Retrieved 23 April 2023.
^"Health product highlights 2021: Annexes of products approved in 2021". Health Canada. 3 August 2022. Retrieved 25 March 2024.
^Cite error: The named reference AHFS2015 was invoked but never defined (see the help page).
^Sanford M (August 2014). "Fingolimod: a review of its use in relapsing-remitting multiple sclerosis". Drugs. 74 (12): 1411–33. doi:10.1007/s40265-014-0264-y. PMID 25063048. S2CID 42807019.
Fingolimod, sold under the brand name Gilenya, is an immunomodulating medication, used for the treatment of multiple sclerosis. Fingolimod is a sphingosine-1-phosphate...
Sphingolipidoses General structures of sphingolipids Dimethylsphingosine Fingolimod Radin N (2003). "Killing tumours by ceramide-induced apoptosis: a critique...
pharmaceutical formulations, particularly in the cases of active ingredients like fingolimod, which is used to treat multiple sclerosis. A notable method for synthesizing...
fumarate itself, (Bafiertam), approved in April 2020. Four S1P modulators: Fingolimod (Gilenya), an oral treatment and the first oral therapy approved for multiple...
established through the clinical work performed during development of fingolimod (trade name Gilenya), a non‐selective S1P modulator.[better source needed]...
nymphs of cicadas. It produces myriocin, from which the synthetic drug fingolimod, a treatment for multiple sclerosis, was developed. Isaria sinclairii...
remyelination after injury or disease. Immunomodulatory drugs such as fingolimod have been shown to reduce immune-mediated damage to the CNS, preventing...
during a 4-year course of dimethyl fumarate, developed PML and died. Fingolimod (Gilenya) was approved in 2010 by the FDA for MS. In 2015, the first case...
roughly equivalent to that of adults. The role of some newer agents such as fingolimod, teriflunomide, and dimethyl fumarate, is not yet entirely clear. Making...
in Penicillium stoloniferum. Thermophilic fungi were the source of the fingolimod precursor myriocin. Aspergillus synthesizes immunosuppressants gliotoxin...
in combination with ciclosporin or tacrolimus in transplant patients. Fingolimod is a synthetic immunosuppressant. It increases the expression or changes...
on lymphocytes and other cell types. Siponimod may be very similar to fingolimod but preventing lymphopenia, one of its main side effects, by preventing...
Sphingosyl phosphatide Chun J, Hartung HP (2010). "Mechanism of action of oral fingolimod (FTY720) in multiple sclerosis". Clinical Neuropharmacology. 33 (2): 91–101...
potent than ciclosporin.[citation needed] The multiple sclerosis drug fingolimod was derived from myriocin by using structure–activity relationship studies...
corticosteroid responsive. There are also anecdotal reports against using fingolimod or alemtuzumab. Residual disability develops in 50–80% of patients, with...
patient's quality of life. PRIMUS has been used to assess the efficacy of fingolimod and rivastigmine. Doward, LC; McKenna, S.P.; Meads, D.M.; Twiss, J; Eckert...
considered to be too low to be of clinical importance in a study. Like fingolimod, which is already approved for the treatment of multiple sclerosis, ponesimod...
that certain immunosuppressants used to treat MS—such as interferon-β, fingolimod, natalizumab, and alemtuzumab—worsen NMO disease progression and should...
history of relapsing forms of multiple sclerosis, after four years of using fingolimod (also known by its brand name Gilenya), another drug used to treat relapsing...
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