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Etrasimod information


Etrasimod
Skeletal formula of etrasimod
Clinical data
Trade namesVelsipity
Other namesAPD334, APD-334
AHFS/Drugs.comMonograph
MedlinePlusa623050
License data
  • US DailyMed: Etrasimod
Routes of
administration		By mouth
Drug classSphingosine-1-phosphate receptor modulator
ATC code
  • L04AE05 (WHO)
Legal status
Legal status
  • AU: S4 (Prescription only)[1]
  • CA: ℞-only[2][3]
  • US: ℞-only[4][5]
  • EU: Rx-only[6][7]
Pharmacokinetic data
Protein binding97.9%
MetabolismLiver (CYP2C8, 2C9, 3A4)
Elimination half-life30 hours
ExcretionFeces (82%), kidneys (5%)
Identifiers
IUPAC name
  • 2-[(3R)-7-{[4-cyclopentyl-3-(trifluoromethyl)phenyl]methoxy}-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl]acetic acid
CAS Number
  • 1206123-37-6
  • as arginine: 1206123-97-8
PubChem CID
  • 44623998
DrugBank
  • DB14766
  • as arginine: DBSALT003430
ChemSpider
  • 52084233
  • as arginine: 57643656
UNII
  • 6WH8495MMH
  • as arginine: MXE5EMA09L
KEGG
  • D10930
  • as arginine: D10931
ChEBI
  • CHEBI:229230
ChEMBL
  • ChEMBL3358920
Chemical and physical data
FormulaC26H26F3NO3
Molar mass457.493 g·mol−1
3D model (JSmol)
  • Interactive image
SMILES
  • C1CCC(C1)C2=C(C=C(C=C2)COC3=CC4=C(C=C3)NC5=C4CC[C@@H]5CC(=O)O)C(F)(F)F
InChI
  • InChI=1S/C26H26F3NO3/c27-26(28,29)22-11-15(5-8-19(22)16-3-1-2-4-16)14-33-18-7-10-23-21(13-18)20-9-6-17(12-24(31)32)25(20)30-23/h5,7-8,10-11,13,16-17,30H,1-4,6,9,12,14H2,(H,31,32)/t17-/m1/s1
  • Key:MVGWUTBTXDYMND-QGZVFWFLSA-N

Etrasimod, sold under the brand name Velsipity, is a medication that is used for the treatment of ulcerative colitis.[4] It is a selective sphingosine-1-phosphate (S1P) receptor modulator that modifies the activity of the immune system.[4] It is taken by mouth.[4]

The most common side effects include lymphopenia (low levels of lymphocytes) and headache.[6]

Etrasimod was discovered by Arena Pharmaceuticals, with subsequent development by Pfizer.[8] Etrasimod was approved for medical use in the United States in October 2023,[4] and in the European Union in February 2024.[6]

  1. ^ "Therapeutic Goods (Poisons Standard—June 2024) Instrument 2024". Federal Register of Legislation. 30 May 2024. Retrieved 10 June 2024.
  2. ^ "Regulatory Decision Summary for Velsipity". Drug and Health Products Portal. 31 January 2024. Retrieved 1 April 2024.
  3. ^ "Notice: Multiple Additions to the Prescription Drug List (PDL) [2024-04-30]". Health Canada. 30 April 2024. Retrieved 3 May 2024.
  4. ^ a b c d e "Velsipity- etrasimod tablet, film coated". DailyMed. 16 November 2023. Retrieved 23 February 2024.
  5. ^ "Velsipity- etrasimod tablet, film coated". DailyMed. 17 November 2023. Retrieved 23 February 2024.
  6. ^ a b c Cite error: The named reference Velsipity EPAR was invoked but never defined (see the help page).
  7. ^ "Velsipity Product information". Union Register of medicinal products. 19 February 2024. Retrieved 23 February 2024.
  8. ^ Bayer M (2 May 2023). "Pfizer tosses newly acquired meds out of the Arena". Fierce Biotech. Retrieved 13 October 2023.

and 23 Related for: Etrasimod information

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Etrasimod

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Etrasimod, sold under the brand name Velsipity, is a medication that is used for the treatment of ulcerative colitis. It is a selective sphingosine-1-phosphate...

Word Count : 698

Arena Pharmaceuticals

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(formerly APD811) in testing for pulmonary arterial hypertension (PAH), etrasimod (formerly APD334) in evaluation for inflammatory indications and APD371...

Word Count : 772

Ceramide

Last Update:

RPC-1063 SEW-2871 Siponimod S1P SPC TC-G 1006 TC-SP 14 W-061 XAX-162 Antagonists: CS-0777 CYM-50358 JTE-013 TY-52156 VPC-23019 W-146 Unsorted: Etrasimod...

Word Count : 3310

Ulcerative colitis

Last Update:

venules by blocking binding to MAdCAM-1. While the medications ozanimod and etrasimod inhibit the sphingosine-1-phosphate receptor to prevent T-cell migration...

Word Count : 16072

Avacincaptad pegol

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Crovalimab Danicopan] Deucravacitinib Efgartigimod alfa (+hyaluronidase) Etrasimod Filgotinib Fingolimod Guselkumab Iptacopan Itacitinib Ixekizumab Netakimab...

Word Count : 299

ATC code L04

Last Update:

Fingolimod L04AE02 Ozanimod L04AE03 Siponimod L04AE04 Ponesimod L04AE05 Etrasimod L04AF01 Tofacitinib L04AF02 Baricitinib L04AF03 Upadacitinib L04AF04 Filgotinib...

Word Count : 367

Fingolimod

Last Update:

RPC-1063 SEW-2871 Siponimod S1P SPC TC-G 1006 TC-SP 14 W-061 XAX-162 Antagonists: CS-0777 CYM-50358 JTE-013 TY-52156 VPC-23019 W-146 Unsorted: Etrasimod...

Word Count : 2539

Sphingosine

Last Update:

RPC-1063 SEW-2871 Siponimod S1P SPC TC-G 1006 TC-SP 14 W-061 XAX-162 Antagonists: CS-0777 CYM-50358 JTE-013 TY-52156 VPC-23019 W-146 Unsorted: Etrasimod...

Word Count : 219

Serine

Last Update:

RPC-1063 SEW-2871 Siponimod S1P SPC TC-G 1006 TC-SP 14 W-061 XAX-162 Antagonists: CS-0777 CYM-50358 JTE-013 TY-52156 VPC-23019 W-146 Unsorted: Etrasimod...

Word Count : 2403

Lysophosphatidylcholine

Last Update:

RPC-1063 SEW-2871 Siponimod S1P SPC TC-G 1006 TC-SP 14 W-061 XAX-162 Antagonists: CS-0777 CYM-50358 JTE-013 TY-52156 VPC-23019 W-146 Unsorted: Etrasimod...

Word Count : 1140

Ponesimod

Last Update:

RPC-1063 SEW-2871 Siponimod S1P SPC TC-G 1006 TC-SP 14 W-061 XAX-162 Antagonists: CS-0777 CYM-50358 JTE-013 TY-52156 VPC-23019 W-146 Unsorted: Etrasimod...

Word Count : 1066

Siponimod

Last Update:

RPC-1063 SEW-2871 Siponimod S1P SPC TC-G 1006 TC-SP 14 W-061 XAX-162 Antagonists: CS-0777 CYM-50358 JTE-013 TY-52156 VPC-23019 W-146 Unsorted: Etrasimod...

Word Count : 798

Ozanimod

Last Update:

RPC-1063 SEW-2871 Siponimod S1P SPC TC-G 1006 TC-SP 14 W-061 XAX-162 Antagonists: CS-0777 CYM-50358 JTE-013 TY-52156 VPC-23019 W-146 Unsorted: Etrasimod...

Word Count : 3240

Oleoylethanolamide

Last Update:

RPC-1063 SEW-2871 Siponimod S1P SPC TC-G 1006 TC-SP 14 W-061 XAX-162 Antagonists: CS-0777 CYM-50358 JTE-013 TY-52156 VPC-23019 W-146 Unsorted: Etrasimod...

Word Count : 654

Safingol

Last Update:

RPC-1063 SEW-2871 Siponimod S1P SPC TC-G 1006 TC-SP 14 W-061 XAX-162 Antagonists: CS-0777 CYM-50358 JTE-013 TY-52156 VPC-23019 W-146 Unsorted: Etrasimod...

Word Count : 871

Ceramidase

Last Update:

RPC-1063 SEW-2871 Siponimod S1P SPC TC-G 1006 TC-SP 14 W-061 XAX-162 Antagonists: CS-0777 CYM-50358 JTE-013 TY-52156 VPC-23019 W-146 Unsorted: Etrasimod...

Word Count : 328

Lysophosphatidic acid

Last Update:

RPC-1063 SEW-2871 Siponimod S1P SPC TC-G 1006 TC-SP 14 W-061 XAX-162 Antagonists: CS-0777 CYM-50358 JTE-013 TY-52156 VPC-23019 W-146 Unsorted: Etrasimod...

Word Count : 717

Sphingosine kinase

Last Update:

RPC-1063 SEW-2871 Siponimod S1P SPC TC-G 1006 TC-SP 14 W-061 XAX-162 Antagonists: CS-0777 CYM-50358 JTE-013 TY-52156 VPC-23019 W-146 Unsorted: Etrasimod...

Word Count : 627

Outline of immunology

Last Update:

Crovalimab Danicopan] Deucravacitinib Efgartigimod alfa (+hyaluronidase) Etrasimod Filgotinib Fingolimod Guselkumab Iptacopan Itacitinib Ixekizumab Netakimab...

Word Count : 2656

Myriocin

Last Update:

RPC-1063 SEW-2871 Siponimod S1P SPC TC-G 1006 TC-SP 14 W-061 XAX-162 Antagonists: CS-0777 CYM-50358 JTE-013 TY-52156 VPC-23019 W-146 Unsorted: Etrasimod...

Word Count : 162

Lysophospholipid receptor

Last Update:

RPC-1063 SEW-2871 Siponimod S1P SPC TC-G 1006 TC-SP 14 W-061 XAX-162 Antagonists: CS-0777 CYM-50358 JTE-013 TY-52156 VPC-23019 W-146 Unsorted: Etrasimod...

Word Count : 476

Lysophosphatidic acid receptor

Last Update:

RPC-1063 SEW-2871 Siponimod S1P SPC TC-G 1006 TC-SP 14 W-061 XAX-162 Antagonists: CS-0777 CYM-50358 JTE-013 TY-52156 VPC-23019 W-146 Unsorted: Etrasimod...

Word Count : 87

Olorinab

Last Update:

NESS-040C5 Tedalinab "Arena Pharmaceuticals Presented New Phase 2 Data for Etrasimod and Olorinab at the 14th Congress of European Crohn's and Colitis Organisation"...

Word Count : 489
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