Spermine synthase (EC 2.5.1.22, spermidine aminopropyltransferase, spermine synthetase) is an enzyme that converts spermidine into spermine.[1][2] This enzyme catalyses the following chemical reaction
Spermine synthase is an enzyme involved in polyamine biosynthesis. It is present in all eukaryotes and plays a role in a variety of biological functions in plants[3] Its structure consists of two identical monomers of 41 kDa with three domains each, creating a homodimer formed via dimerization. The interactions between one of the three domains, the N-terminals of the monomers, is responsible for dimerization as that is where the active site is located; the central terminal consisting of four β- strands structurally forming a lid for the third domain, the C-terminal domain.[4]
^Hibasami H, Borchardt RT, Chen SY, Coward JK, Pegg AE (May 1980). "Studies of inhibition of rat spermidine synthase and spermine synthase". The Biochemical Journal. 187 (2): 419–28. doi:10.1042/bj1870419. PMC 1161808. PMID 7396856.
^Pajula RL, Raina A, Eloranta T (November 1979). "Polyamine synthesis in mammalian tissues. Isolation and characterization of spermine synthase from bovine brain". European Journal of Biochemistry. 101 (2): 619–26. doi:10.1111/j.1432-1033.1979.tb19756.x. PMID 520313.
^Imamura T, Fujita K, Tasaki K, Higuchi A, Takahashi H (August 2015). "Characterization of spermidine synthase and spermine synthase--The polyamine-synthetic enzymes that induce early flowering in Gentiana triflora". Biochemical and Biophysical Research Communications. 463 (4): 781–6. doi:10.1016/j.bbrc.2015.06.013. PMID 26056006.
^Pegg AE, Michael AJ (January 2010). "Spermine synthase". Cellular and Molecular Life Sciences. 67 (1): 113–21. doi:10.1007/s00018-009-0165-5. PMC 2822986. PMID 19859664.
Sperminesynthase (EC 2.5.1.22, spermidine aminopropyltransferase, spermine synthetase) is an enzyme that converts spermidine into spermine. This enzyme...
Spermine is a polyamine involved in cellular metabolism that is found in all eukaryotic cells. The precursor for synthesis of spermine is the amino acid...
by spermidine synthase. Spermine is synthesized from the reaction of spermidine with SAM in the presence of the enzyme sperminesynthase. The polyamines...
Probable global transcription activator SNF2L1 SMS: encoding enzyme Sperminesynthase SPANXN1: encoding protein SPANX family member N1 SPANXN5: encoding...
2007). "Putative sperminesynthases from Thalassiosira pseudonana and Arabidopsis thaliana synthesize thermospermine rather than spermine". FEBS Letters...
polyamine. Spermidine synthase (SPDS) catalyzes its formation from putrescine. It is a precursor to other polyamines, such as spermine and its structural...
Nitric oxide synthases (EC 1.14.13.39) (NOSs) are a family of enzymes catalyzing the production of nitric oxide (NO) from L-arginine. NO is an important...
complex. There are a few active sites that include polyamine spermidine/sperminesynthases, and loop-closures occur upon the binding of spermidine, and a catalytic...
transition state analogues as Adodato (for further information see here) Sperminesynthase Adenosylmethionine decarboxylase Ikeguchi Y, Bewley MC, Pegg AE (January...
Endothelial NOS (eNOS), also known as nitric oxide synthase 3 (NOS3) or constitutive NOS (cNOS), is an enzyme that in humans is encoded by the NOS3 gene...
receptor 2 (SSTR2)as well as a variety of other somatostatin receptors, sperminesynthase (SMS), and TMEM132C. All of the somatostatin related proteins are...
placental-specific escape from X-chromosome inactivation by the enzyme sperminesynthase (SMS); moreover, maternal serum levels of polyamine metabolites differ...
is combined with another S-adenosylmethioninamine and gets converted to spermine. Putrescine is synthesized in small quantities by healthy living cells...
Nitric oxide synthase 1 (neuronal), also known as NOS1, is an enzyme that in humans is encoded by the NOS1 gene. Nitric oxide synthases (EC 1.14.13.39)...
structure and regulation of ornithine decarboxylase, spermidine synthase, sperminesynthase, and S-adenosylmethionine decarboxylase. Tabor was elected to...
requires the enzyme glutamate–cysteine ligase (GCL, glutamate cysteine synthase). This reaction is the rate-limiting step in glutathione synthesis. Second...
cofactor for the production of nitric oxide (NO) by the nitric oxide synthases. Chemically, its structure is that of a (dihydropteridine reductase) reduced...
Entering the flavone synthesis pathway, the type III polyketide synthase enzyme chalcone synthase (CHS) uses consecutive condensations of three equivalents...
In the liver of vertebrates, glycine synthesis is catalyzed by glycine synthase (also called glycine cleavage enzyme). This conversion is readily reversible:...
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