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Spermidine synthase information


spermidine synthase
Spermidine synthase tetramer, Bacillus subtilis
Identifiers
SymbolSRM
Alt. symbolsSRML1
NCBI gene6723
HGNC11296
OMIM182891
RefSeqNM_003132
UniProtP19623
Other data
EC number2.5.1.16
LocusChr. 1 p36-p22
Search for
StructuresSwiss-model
DomainsInterPro

Spermidine synthase is an enzyme (EC 2.5.1.16) that catalyzes the transfer of the propylamine group from S-adenosylmethioninamine to putrescine in the biosynthesis of spermidine. The systematic name is S-adenosyl 3-(methylthio)propylamine:putrescine 3-aminopropyltransferase and it belongs to the group of aminopropyl transferases. It does not need any cofactors. Most spermidine synthases exist in solution as dimers.[1]

  1. ^ Ikeguchi Y, Bewley MC, Pegg AE (January 2006). "Aminopropyltransferases: function, structure and genetics". Journal of Biochemistry. 139 (1): 1–9. doi:10.1093/jb/mvj019. PMID 16428313.

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Spermidine synthase

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Spermidine synthase is an enzyme (EC 2.5.1.16) that catalyzes the transfer of the propylamine group from S-adenosylmethioninamine to putrescine in the...

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Spermidine

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organisms. It was originally isolated from semen. Spermidine is an aliphatic polyamine. Spermidine synthase (SPDS) catalyzes its formation from putrescine...

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Spermine synthase

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Spermine synthase (EC 2.5.1.22, spermidine aminopropyltransferase, spermine synthetase) is an enzyme that converts spermidine into spermine. This enzyme...

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Polyamine

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catalyzed by spermidine synthase. Spermine is synthesized from the reaction of spermidine with SAM in the presence of the enzyme spermine synthase. The polyamines...

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Deoxyhypusine synthase

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Deoxyhypusine synthase (EC 2.5.1.46, spermidine:eIF5A-lysine 4-aminobutyltransferase (propane-1,3-diamine-forming)) is an enzyme with systematic name...

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BpsA

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BpsA (N(4)-bis(aminopropyl)spermidine synthase) is a single-module non-ribosomal peptide synthase (NRPS) (also see non-ribosomal peptide (NPR)) located...

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Homospermidine synthase

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{\displaystyle \rightleftharpoons } sym-homospermidine + NH3 + H+ (2) putrescine + spermidine ⇌ {\displaystyle \rightleftharpoons } sym-homospermidine + propane-1,3-diamine...

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Glutathionylspermidine synthase

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a glutathionylspermidine synthase (EC 6.3.1.8) is an enzyme that catalyzes the chemical reaction glutathione + spermidine + ATP ⇌ {\displaystyle \rightleftharpoons...

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Thermospermine synthase

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Thermospermine synthase (EC 2.5.1.79, TSPMS, ACL5 (ACAULIS5), SAC51) is an enzyme with systematic name S-adenosylmethioninamine:spermidine 3-aminopropyltransferase...

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Trypanothione synthase

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+ ATP ⇌ {\displaystyle \rightleftharpoons } N1,N8-bis(glutathionyl)spermidine + ADP + phosphate The 3 substrates of this enzyme are glutathione,...

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Spee

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Montevideo in 1939 Spee Club, a coed final club at Harvard University Spermidine synthase, an enzyme This disambiguation page lists articles associated with...

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Putrescine

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described. Spermidine synthase uses putrescine and S-adenosylmethioninamine (decarboxylated S-adenosyl methionine) to produce spermidine. Spermidine in turn...

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Spermine

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Thereafter the enzyme spermidine synthase effects two N-alkylation by decarboxy-S-adenosyl methionine. The intermediate is spermidine. Plants employ additional...

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Housekeeping gene

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current name reflects their relative upregulation in testes SPAG7 SRM Spermidine synthase TEGT Bax-1 inhibitor DAZAP2 Deleted in azoospermia MEA1 Male enhanced...

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Carboxynorspermidine synthase

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DJ, Woster PM, Phillips MA, Michael AJ (December 2011). "Alternative spermidine biosynthetic route is critical for growth of Campylobacter jejuni and...

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Ornithine decarboxylase

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division. Spermidine synthase can then catalyze the conversion of putrescine to spermidine by the attachment of an aminopropyl moiety. Spermidine is a precursor...

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DHPS

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hypusine biosynthesis, deoxyhypusine synthase catalyzes the NAD-dependent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific...

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Monocrotaline

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propylamino group from decarboxylated S-adenosylmethioninamine (4: spermidine synthase). Spermidine and another molecule of putrescine react to form the symmetric...

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Herbert Tabor

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the structure and regulation of ornithine decarboxylase, spermidine synthase, spermine synthase, and S-adenosylmethionine decarboxylase. Tabor was elected...

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Hypusine

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and two enzymes are involved: 1. Deoxyhypusine synthase catalyzes the cleavage of the polyamine spermidine and transfer of its 4-aminobutyl moiety to the...

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Pyrrolizidine alkaloid

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Homospermidine synthase. The polyamines putrescine and spermidine are derived from the basic amino acid arginine. Subsequently, homospermidine synthase exchanges...

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Apigenin

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Entering the flavone synthesis pathway, the type III polyketide synthase enzyme chalcone synthase (CHS) uses consecutive condensations of three equivalents...

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Senecionine

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readily converted to putrescine and spermidine. Next, in an NAD+-dependent reaction catalyzed by homospermidine synthase (HSS), an aminopropyl group from...

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