Protein-coding gene in the species Homo sapiens
NOS1 Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4D1N, 4UCH, 4UH5, 4UH6, 4V3U, 5ADF, 5ADG, 5ADI, 5FVX, 5FVW, 5FVU, 5FVV
Identifiers Aliases NOS1 , IHPS1, N-NOS, NC-NOS, NOS, bNOS, nNOS, nitric oxide synthase 1External IDs OMIM: 163731 MGI: 97360 HomoloGene: 37327 GeneCards: NOS1 Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q24.22 Start 117,208,142 bp[1] End 117,452,170 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5 F|5 57.29 cM Start 117,919,097 bp[2] End 118,096,905 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in body of tongue biceps brachii pons gastrocnemius muscle spinal ganglia vastus lateralis muscle deltoid muscle putamen trigeminal ganglion tibialis anterior muscle
Top expressed in pontine nuclei subiculum digastric muscle temporal muscle mammillary body dorsal tegmental nucleus ventromedial nucleus lateral hypothalamus sternocleidomastoid muscle medial vestibular nucleus
More reference expression data
BioGPS More reference expression data
Gene ontology Molecular function
transmembrane transporter binding
tetrahydrobiopterin binding
NADP binding
cadmium ion binding
FMN binding
metal ion binding
heme binding
oxidoreductase activity
scaffold protein binding
calmodulin binding
protein binding
sodium channel regulator activity
flavin adenine dinucleotide binding
arginine binding
nitric-oxide synthase activity
NADPH-hemoprotein reductase activity
Cellular component
membrane
photoreceptor inner segment
T-tubule
synapse
ryanodine receptor complex
mitochondrion
perinuclear region of cytoplasm
caveola
cytoskeleton
cell projection
dendritic spine
Z disc
sarcoplasmic reticulum membrane
membrane raft
sarcoplasmic reticulum
sarcolemma
cytosol
cytoplasm
nucleoplasm
plasma membrane
protein-containing complex
calyx of Held
nucleus
vesicle membrane
postsynaptic density
Biological process
multicellular organismal response to stress
positive regulation of guanylate cyclase activity
regulation of sodium ion transport
positive regulation of the force of heart contraction
negative regulation of hydrolase activity
striated muscle contraction
regulation of neurogenesis
negative regulation of serotonin uptake
positive regulation of transcription, DNA-templated
peptidyl-cysteine S-nitrosylation
cell redox homeostasis
arginine catabolic process
negative regulation of potassium ion transport
nitric oxide mediated signal transduction
negative regulation of calcium ion transport into cytosol
myoblast fusion
regulation of calcium ion transmembrane transport via high voltage-gated calcium channel
regulation of ryanodine-sensitive calcium-release channel activity
regulation of cardiac conduction
nitric oxide biosynthetic process
positive regulation of sodium ion transmembrane transport
cellular response to growth factor stimulus
neurotransmitter biosynthetic process
positive regulation of histone acetylation
negative regulation of calcium ion transport
regulation of cardiac muscle contraction
positive regulation of transcription by RNA polymerase II
response to hypoxia
response to heat
negative regulation of blood pressure
retrograde trans-synaptic signaling by nitric oxide
vasodilation
positive regulation of adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process
synaptic signaling by nitric oxide
response to hormone
response to lipopolysaccharide
positive regulation of peptidyl-serine phosphorylation
Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez Ensembl UniProt RefSeq (mRNA) NM_000620 NM_001204213 NM_001204214 NM_001204218
RefSeq (protein) NP_000611 NP_001191142 NP_001191143 NP_001191147
Location (UCSC) Chr 12: 117.21 – 117.45 Mb Chr 5: 117.92 – 118.1 Mb PubMed search [3] [4]
Wikidata View/Edit Human View/Edit Mouse
Nitric oxide synthase 1 (neuronal) , also known as NOS1 , is an enzyme that in humans is encoded by the NOS1 gene.[5] [6]
^ a b c GRCh38: Ensembl release 89: ENSG00000089250 – Ensembl, May 2017
^ a b c GRCm38: Ensembl release 89: ENSMUSG00000029361 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine .
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine .
^ Kishimoto J, Spurr N, Liao M, Lizhi L, Emson P, Xu W (November 1992). "Localization of brain nitric oxide synthase (NOS) to human chromosome 12". Genomics . 14 (3): 802–4. doi:10.1016/S0888-7543(05)80192-2. PMID 1385308.
^ Geller DA, Lowenstein CJ, Shapiro RA, Nussler AK, Di Silvio M, Wang SC, Nakayama DK, Simmons RL, Snyder SH, Billiar TR (April 1993). "Molecular cloning and expression of inducible nitric oxide synthase from human hepatocytes". Proc. Natl. Acad. Sci. U.S.A . 90 (8): 3491–5. Bibcode:1993PNAS...90.3491G. doi:10.1073/pnas.90.8.3491 . PMC 46326 . PMID 7682706.
Last Update: 2023-12-22T22:37:31Z
Nitric oxide synthase 1 (neuronal), also known as NOS1 , is an enzyme that in humans is encoded by the NOS1 gene. Nitric oxide synthases (EC 1.14.13.39) (NOSs)...
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Last Update: 2023-12-24T18:20:48Z
Cloning of NOS enzymes indicates that cNOS include both brain constitutive (NOS1 ) and endothelial constitutive (NOS3); the third is the inducible (NOS2) gene...
Word Count : 3161
Last Update: 2024-04-07T03:00:59Z
Newton-Cheh C, Ikeda M, et al. (June 2006). "A common genetic variant in the NOS1 regulator NOS1AP modulates cardiac repolarization". Nature Genetics. 38 (6):...
Word Count : 3277
Last Update: 2024-04-28T08:07:45Z
Inh L1-6 LAMP5 CA1 unknown unknown brain None None unknown None HS3ST4, NOS1 Inh L1-6 LAMP5 NES unknown unknown brain None None unknown None EPHA3, EYA4...
Word Count : 1179
Last Update: 2023-03-03T22:36:25Z
NOA1 Identifiers Aliases NOA1, C4orf14, MTG3, hAtNOS1 , hmAtNOS1 , nitric oxide associated 1 External IDs OMIM: 614919 MGI: 1914306 HomoloGene: 10518 GeneCards:...
Word Count : 73
Last Update: 2023-12-19T03:04:31Z
GRIN2C HER2/neu HGS KCNA2 KCNA4 KCNA5 KCNJ12 Kir2.1 LGI1 LRP1 LRP2 NLGN1 NOS1 PTK2B SEMA4C and SHANK2. Postsynaptic density GRCh38: Ensembl release 89:...
Word Count : 2725
Last Update: 2023-12-03T02:04:30Z
MAST3 MAST4 MCSP MLLT4 MPDZ MPP1 MPP2 MPP3 MPP4 MPP5 MPP6 MPP7 MYO18A NHERF1 NOS1 PARD3 PARD6A PARD6B PARD6G PDLIM1 PDLIM2 PDLIM3 PDLIM4 PDLIM5 PDLIM7 PDZD11...
Word Count : 3565
Last Update: 2023-05-27T16:25:38Z
Nicholls, 1994, Penguin India, First published by Chicago Review (Vol. 38, Nos1 & 2), 1992 Survival, eds. Daniel Weissbort & Girdhar Rathi. Sahitya Akademi...
Word Count : 952
Last Update: 2023-12-15T12:00:07Z
Merrill Moore, 1903-57 Christchurch: Pegasus Press, 1961 Quaffers' Gazette, nos1 -22. Edited by Glover. Hamilton: Waikato Breweries Ltd, 1962–66 Poetry and...
Word Count : 2330
Last Update: 2023-11-29T06:14:29Z
phthalate dioxygenase reductase, and various other flavoproteins. MTRR; NDOR1; NOS1 ; NOS2A; NOS3; NR1; POR; Hyde GE, Crawford NM, Campbell WH (1991). "The sequence...
Word Count : 399
Last Update: 2024-04-06T21:47:41Z
QT interval length. NOS1AP has been shown to interact with: LRP1, LRP2, NOS1 , RASD1, SYN1 GRCh38: Ensembl release 89: ENSG00000198929 – Ensembl, May 2017...
Word Count : 802
Last Update: 2023-11-24T12:15:46Z
NANOS1 Identifiers Aliases NANOS1, NOS1 , SPGF12, EC_Rep1a, NOS-1, nanos homolog 1 (Drosophila), ZC2HC12A, nanos C2HC-type zinc finger 1 External IDs OMIM:...
Word Count : 540