Soluble guanylate cyclase (sGC) stimulators are a class of drugs developed to treat heart failure, pulmonary hypertension, and other diseases. The first-in-class medication was riociguat, approved in 2013 for pulmonary hypertension.[1][2] They have also been investigated for hypertension, systemic sclerosis, and sickle cell disease.[3][1]
^ abCite error: The named reference degruyter was invoked but never defined (see the help page).
^Sandner, Peter; Vakalopoulos, Alexandros; Hahn, Michael G.; Stasch, Johannes-Peter; Follmann, Markus (4 March 2021). "Soluble guanylate cyclase stimulators and their potential use: a patent review". Expert Opinion on Therapeutic Patents. 31 (3): 203–222. doi:10.1080/13543776.2021.1866538. ISSN 1354-3776.
^Cite error: The named reference Stasch was invoked but never defined (see the help page).
and 27 Related for: Soluble guanylate cyclase stimulator information
Solubleguanylatecyclase (sGC) stimulators are a class of drugs developed to treat heart failure, pulmonary hypertension, and other diseases. The first-in-class...
Guanylatecyclase (EC 4.6.1.2, also known as guanyl cyclase, guanylyl cyclase, or GC; systematic name GTP diphosphate-lyase (cyclizing; 3′,5′-cyclic-GMP-forming))...
brand name Adempas, is a medication by Bayer that is a stimulator of solubleguanylatecyclase (sGC). It is used to treat two forms of pulmonary hypertension...
Soluble guanylyl cyclase (sGC) is the only known gasoreceptor for nitric oxide, NO. It is soluble, i.e. completely intracellular. Most notably, this enzyme...
decompensation event. It is taken by mouth. Vericiguat is a solubleguanylatecyclase (sGC) stimulator. Common side effects include low blood pressure and low...
Runcaciguat is a solubleguanylatecyclasestimulator developed by Bayer for non-proliferative diabetic retinopathy and chronic kidney disease. Bénardeau...
Olinciguat (IW-1701) is a solubleguanylatecyclasestimulator that was in development for sickle cell anemia. After receiving orphan drug status in 2018...
Adenylate cyclase (EC 4.6.1.1, also commonly known as adenyl cyclase and adenylyl cyclase, abbreviated AC) is an enzyme with systematic name ATP diphosphate-lyase...
and platelets), where it increases the activity of the enzyme solubleguanylatecyclase, leading to increased formation of cyclic guanosine monophosphate...
PMID 10406194. Derbyshire ER, Marletta MA (2009). "Biochemistry of SolubleGuanylateCyclase". CGMP: Generators, Effectors and Therapeutic Implications. Handbook...
systems can be synthesized and activated by enzymes, for example, the cyclases that synthesize cyclic nucleotides, or by opening of ion channels to allow...
Activation of purified solubleguanylatecyclase by endothelium-derived relaxing factor from intrapulmonary artery and vein: stimulation by acetylcholine,...
of acute decompensated heart failure. Cinaciguat activates the solubleguanylatecyclase (sGC) which is a receptor for nitric oxide. This increases biosynthesis...
of enzymes. NO stimulates the soluble form of the enzyme guanylatecyclase in the smooth muscle cells of blood vessels. Guanylatecyclase produces cyclic...
infarction. The primary receiver for NO produced by eNOS and nNOS is solubleguanylatecyclase, but many secondary targets have been identified. S-nitrosylation...
guanylyl cyclase family because it contains two guanylatecyclase domains. ADCY2 is one of ten different mammalian isoforms of adenylyl cyclases. ADCY2...
in the mouse main olfactory epithelium of type B express the solubleguanylatecyclase Gucy1b2". Molecular and Cellular Neuroscience. 65: 114–124. doi:10...
also known as atrionatriuretic peptide receptor B and formerly as guanylatecyclase B, is an atrial natriuretic peptide receptor which in humans is encoded...
the heart's having to do less work. There is also a soluble guanylyl cyclase that cannot be stimulated by ANP. Instead, vascular endothelial cells will use...
nitrites (commonly known as "poppers") Concomitant use of soluble guanylyl cyclasestimulators, such as riociguat Known hypersensitivity to sildenafil Sildenafil...
Mullenix JB, Patel TB (1997). "Characterization of soluble forms of nonchimeric type V adenylyl cyclases". Proc. Natl. Acad. Sci. U.S.A. 94 (7): 2915–20...
Adenylyl cyclase type 9 is an enzyme that in humans is encoded by the ADCY9 gene. Adenylyl cyclase is a membrane bound enzyme that catalyses the formation...
Serine/threonine-specific protein kinase, as in bone morphogenetic protein Guanylatecyclase, as in atrial natriuretic factor receptor Intracellular receptors...
Adenylyl cyclase type 1 is an enzyme that in humans is encoded by the ADCY1 gene. This gene encodes a form of adenylyl cyclase expressed in the brain...
Global Information