dentate gyrus of hippocampal formation granule cell
subiculum
piriform cortex
nucleus accumbens
cerebellar vermis
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
phosphatase binding
spectrin binding
structural constituent of cytoskeleton
protein binding
ankyrin binding
actin binding
phospholipid binding
Cellular component
cytoplasm
cytosol
PML body
spectrin
membrane
cell body fiber
nuclear matrix
adherens junction
plasma membrane
node of Ranvier
axon
neuronal cell body
cell cortex
axon hillock
axon initial segment
paranode region of axon
extracellular exosome
cytoskeleton
intercalated disc
Biological process
clustering of voltage-gated sodium channels
axonogenesis
regulation of sodium ion transport
transmission of nerve impulse
hearing
negative regulation of heart rate
MAPK cascade
axon guidance
endoplasmic reticulum to Golgi vesicle-mediated transport
reproductive process
adult behavior
cardiac conduction
regulation of peptidyl-serine phosphorylation
actin filament capping
positive regulation of multicellular organism growth
fertilization
central nervous system projection neuron axonogenesis
vesicle-mediated transport
adult walking behavior
protein localization to plasma membrane
regulation of molecular function
cytoskeleton organization
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
57731
80297
Ensembl
ENSG00000160460
ENSMUSG00000011751
UniProt
Q9H254
n/a
RefSeq (mRNA)
NM_020971 NM_025213
NM_001199234 NM_001199235 NM_001199236 NM_032610
RefSeq (protein)
NP_066022 NP_079489
n/a
Location (UCSC)
Chr 19: 40.47 – 40.58 Mb
Chr 7: 27.06 – 27.15 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Spectrin, beta, non-erythrocytic 4, also known as SPTBN4, is a protein that in humans is encoded by the SPTBN4 gene.[5][6]
Spectrin is an actin crosslinking and molecular scaffold protein that links the cell membrane to the actin cytoskeleton, and functions in the determination of cell shape, arrangement of transmembrane proteins, and organization of organelles. It is composed of two antiparallel dimers of alpha- and beta- subunits. This gene is one member of a family of beta-spectrin genes. The encoded protein localizes to the nuclear matrix, PML nuclear bodies, and cytoplasmic vesicles. A highly similar gene in the mouse is required for localization of specific membrane proteins in polarized regions of neurons. Multiple transcript variants encoding different isoforms have been found for this gene.[5]
^ abcGRCh38: Ensembl release 89: ENSG00000160460 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000011751 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Berghs S, Aggujaro D, Dirkx R, Maksimova E, Stabach P, Hermel JM, Zhang JP, Philbrick W, Slepnev V, Ort T, Solimena M (November 2000). "betaIV spectrin, a new spectrin localized at axon initial segments and nodes of ranvier in the central and peripheral nervous system". J. Cell Biol. 151 (5): 985–1002. doi:10.1083/jcb.151.5.985. PMC 2174349. PMID 11086001.
Spectrin, beta, non-erythrocytic 4, also known as SPTBN4, is a protein that in humans is encoded by the SPTBN4 gene. Spectrin is an actin crosslinking and molecular...
Global Information
