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FtsZ information


Cell division protein FtsZ
Identifiers
SymbolFtsZ
InterProIPR000158
CATH1fsz
SCOP21fsz / SCOPe / SUPFAM
CDDcd02201
FtsZ, C-terminal sandwich
Identifiers
SymbolFtsZ_C
PfamPF12327
InterProIPR024757
Available protein structures:
Pfam  structures / ECOD  
PDBRCSB PDB; PDBe; PDBj
PDBsumstructure summary
Cell division protein FtsZ
Molecular Structure of FtsZ (PDB 1fsz).
Identifiers
OrganismEscherichia coli
SymbolftsZ
UniProtP0A9A6
Search for
StructuresSwiss-model
DomainsInterPro

FtsZ is a protein encoded by the ftsZ gene that assembles into a ring at the future site of bacterial cell division (also called the Z ring). FtsZ is a prokaryotic homologue of the eukaryotic protein tubulin. The initials FtsZ mean "Filamenting temperature-sensitive mutant Z." The hypothesis was that cell division mutants of E. coli would grow as filaments due to the inability of the daughter cells to separate from one another. FtsZ is found in almost all bacteria, many archaea, all chloroplasts and some mitochondria, where it is essential for cell division. FtsZ assembles the cytoskeletal scaffold of the Z ring that, along with additional proteins, constricts to divide the cell in two.

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FtsZ

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FtsZ is a protein encoded by the ftsZ gene that assembles into a ring at the future site of bacterial cell division (also called the Z ring). FtsZ is a...

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Tubulin

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Tubulin/FtsZ family, GTPase protein domain. This GTPase protein domain is found in all eukaryotic tubulin chains, as well as the bacterial protein TubZ, the...

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FtsA

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the FtsA-FtsA interface. FtsA localizes to the cytokinetic ring formed by FtsZ (Z ring). One of FtsA's functions in cytokinesis is to tether FtsZ polymers...

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Cytoskeleton

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are tubulin in eukaryotes and FtsZ, TubZ, RepX in prokaryotes. Actin-like proteins are actin in eukaryotes and MreB, FtsA in prokaryotes. An example of...

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Mitochondrial fission

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FtsZ proteins into a ring around the center of the mitochondria and some proteins tethered to the inner mitochondrial membrane also help anchor the Z...

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Prokaryotic cytoskeleton

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prokaryotes. FtsZ, the first identified prokaryotic cytoskeletal element, forms a filamentous ring structure located in the middle of the cell called the Z-ring...

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Treadmilling

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treadmilling occurs in cells. FtsZ treadmilling The bacterial tubulin homolog FtsZ is one of the best documented treadmilling polymers. FtsZ assembles into protofilaments...

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Mechanism of action

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inhibited, and filamentation of target cells can be an indication that PBP3, FtsZ, or DNA synthesis is being inhibited. Other antibacterial agent-induced changes...

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Min System

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division. Each component participates in generating a dynamic oscillation of FtsZ protein inhibition between the two bacterial poles to precisely specify the...

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Divisome

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FtsZ ring. FtsA protein binds directly to FtsZ in the cytoplasm, and FtsB, FtsL and FtsQ form an essential membrane-embedded subcomplex. FtsK and FtsW...

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Biology

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new cell wall begins to separate the bacterium (triggered by FtsZ polymerization and "Z-ring" formation). The new cell wall (septum) fully develops, resulting...

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Planctomycetota

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FtsZ proteins. Bacteria in the Chlamydiales, also a member of the PVC superphylum, also lack FtsZ. Although bacteria in the Planctomycetota lack FtsZ...

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FtsK

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as they only occur in Actinomycetota and Bacillota. FtsZ – Protein encoded by the ftsZ gene FtsA – Bacterial protein that is related to actin Yu XC,...

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Troponin I

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t e Proteins of the cytoskeleton Human Nonhuman Major sperm proteins Prokaryotic cytoskeleton Crescentin FtsZ MreB ParM See also: cytoskeletal defects...

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Bartonella

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Zeaiter Z, Liang Z, Raoult D (2002). "Genetic classification and differentiation of Bartonella species based on comparison of partial ftsZ gene sequences"...

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Tubulin domain

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Tubulin/FtsZ family, GTPase domain is an evolutionary conserved protein domain. This domain is found in all tubulin chains, as well as the bacterial FtsZ family...

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Cyanobacterial morphology

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require cytoskeletal elements was finally abolished by the discovery of FtsZ, a prokaryotic tubulin homolog, and MreB, a bacterial actin homolog. These...

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Prokaryote

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that of the eukaryotes. Besides homologues of actin and tubulin (MreB and FtsZ), the helically arranged building-block of the flagellum, flagellin, is one...

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Microtubule

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material, and other roles. Prokaryotes possess tubulin-like proteins including FtsZ. However, prokaryotic flagella are entirely different in structure from eukaryotic...

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Filamentation

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Bacteria inhibit septation by synthesizing protein SulA, an FtsZ inhibitor that halts Z-ring formation, thereby stopping recruitment and activation of...

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Troponin

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t e Proteins of the cytoskeleton Human Nonhuman Major sperm proteins Prokaryotic cytoskeleton Crescentin FtsZ MreB ParM See also: cytoskeletal defects...

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Rickettsia

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10-amino-acid insertion in ribosomal protein L19, a one-amino-acid insertion in FtsZ, a one-amino-acid insertion in major sigma factor 70, and a one-amino-acid...

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ZapA family

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antiparallel coiled coils. ZapA interacts with FtsZ, where FtsZ is part of a mid-cell cytokinetic structure termed the Z-ring that recruits a hierarchy of fission...

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Cell division

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the peptidoglycan cell wall at the division site. A tubulin-like protein, FtsZ plays a critical role in formation of a contractile ring for the cell division...

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GTPase

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PMID 27658684. Nogales E, Downing KH, Amos LA, Löwe J (June 1998). "Tubulin and FtsZ form a distinct family of GTPases". Nat. Struct. Biol. 5 (6): 451–8. doi:10...

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Keratin

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t e Proteins of the cytoskeleton Human Nonhuman Major sperm proteins Prokaryotic cytoskeleton Crescentin FtsZ MreB ParM See also: cytoskeletal defects...

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Totarol

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inhibit gram-positive and acid-fast bacteria via inhibition of FtsZ protein, which forms the Z-ring, a polymer necessary for efficient bacterial cell cytokinesis...

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