SMC3 information

SMC3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2WD5
Identifiers
Aliases	SMC3, BAM, BMH, CDLS3, CSPG6, HCAP, SMC3L1, structural maintenance of chromosomes 3
External IDs	OMIM: 606062; MGI: 1339795; HomoloGene: 3974; GeneCards: SMC3; OMA:SMC3 - orthologs
Gene location (Human)
Chr.	Chromosome 10 (human)
End	110,606,048 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	53,634,264 bp
RNA expression pattern
	Top expressed in
	tendon of biceps brachii; ; ventricular zone; ; oocyte; ; testicle; ; gonad; ; ganglionic eminence; ; internal globus pallidus; ; Achilles tendon; ; secondary oocyte; ; superior surface of tongue;
	Top expressed in
	genital tubercle; ; tail of embryo; ; fetal liver hematopoietic progenitor cell; ; ventricular zone; ; mandibular prominence; ; maxillary prominence; ; epiblast; ; hand; ; secondary oocyte; ; somite;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	microtubule motor activity; nucleotide binding; mediator complex binding; chromatin binding; protein binding; protein heterodimerization activity; ATP binding; dynein complex binding; beta-tubulin binding; protein-containing complex binding;
Cellular component	cytosol; meiotic cohesin complex; nuclear matrix; chromosome; nucleoplasm; lateral element; chromatin; chromosome, centromeric region; nucleus; basement membrane; intracellular anatomical structure; cohesin complex; mitotic spindle pole;
Biological process	regulation of DNA replication; chromosome organization; cellular response to DNA damage stimulus; stem cell population maintenance; cell division; negative regulation of DNA endoreduplication; cell cycle; DNA repair; sister chromatid cohesion; mitotic cell cycle; meiosis; regulation of mitotic spindle assembly;
	Sources:Amigo / QuickGO
Orthologs
	9126
	13006
	ENSG00000108055
	ENSMUSG00000024974
	Q9UQE7
	Q9CW03
	NM_005445
	NM_007790
	NP_005436
	NP_031816
	Wikidata
View/Edit Human	View/Edit Mouse

Structural maintenance of chromosomes protein 3 (SMC3) is a protein that in humans is encoded by the SMC3 gene.^[5] SMC3 is a subunit of the Cohesin complex which mediates sister chromatid cohesion, homologous recombination and DNA looping. Cohesin is formed of SMC3, SMC1, RAD21 and either SA1 or SA2. In humans, SMC3 is present in all cohesin complexes whereas there are multiple paralogs for the other subunits.

SMC3 is a member of the SMC protein family. Members of this family are key regulators of DNA repair, chromosome condensation and chromosome segregation.

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000108055 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000024974 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: SMC3 structural maintenance of chromosomes 3".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000108055 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000024974 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: SMC3 structural maintenance of chromosomes 3".

SMC3 information

and 27 Related for: SMC3 information

SMC3

Cornelia de Lange syndrome

Cohesin

SMC protein

STAG1

SMC1A

RAD21

STAG2

WAPAL

Establishment of sister chromatid cohesion

REC8

PDS5B

SMC1B

Chromomere

Nuclear organization

Shugoshin 1

IFT88

Acute megakaryoblastic leukemia

SMC5

Condensin

Holocentric chromosome

Chondroitin sulfate proteoglycan

Biochemical switches in the cell cycle

Kim Nasmyth

Perinucleolar compartment

MXI1

Transient myeloproliferative disease