Cohesin subunit SA-2 (SA2) is a protein that in humans is encoded by the STAG2 gene.[5][6] SA2 is a subunit of the Cohesin complex which mediates sister chromatid cohesion, homologous recombination and DNA looping. In somatic cells cohesin is formed of SMC3, SMC1, RAD21 and either SA1 or SA2 whereas in meiosis, cohesin is formed of SMC3, SMC1B, REC8 and SA3.
STAG2 is frequently mutated in a range of cancers [7] and several other disorders.
^ abcGRCh38: Ensembl release 89: ENSG00000101972 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000025862 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Carramolino L, Lee BC, Zaballos A, Peled A, Barthelemy I, Shav-Tal Y, et al. (August 1997). "SA-1, a nuclear protein encoded by one member of a novel gene family: molecular cloning and detection in hemopoietic organs". Gene. 195 (2): 151–159. doi:10.1016/S0378-1119(97)00121-2. PMID 9305759.
^"Entrez Gene: STAG2 stromal antigen 2".
^De Koninck M, Losada A (December 2016). "Cohesin Mutations in Cancer". Cold Spring Harbor Perspectives in Medicine. 6 (12): a026476. doi:10.1101/cshperspect.a026476. PMC 5131750. PMID 27742736.
Cohesin subunit SA-2 (SA2) is a protein that in humans is encoded by the STAG2 gene. SA2 is a subunit of the Cohesin complex which mediates sister chromatid...
frequency. Similarly, mutations to the gene Stag2 have been associated with increased aneuploidy in cancers. Stag2 encodes a cohesin protein responsible for...
A, Losada A (April 2020). "Specialized functions of cohesins STAG1 and STAG2 in 3D genome architecture". Current Opinion in Genetics & Development. Genome...
is localized. KIAA2012 has predicted protein interactions with STAG2 and SMC1A. STAG2 encodes a subunit of cohesion complexes used to regulate sister...
Márquez M, Vazquez M, et al. (December 2013). "Recurrent inactivation of STAG2 in bladder cancer is not associated with aneuploidy". Nature Genetics. 45...
somatic mutations in at least three other genes viz., ASXL1, SETBP1, and STAG2. Independently of GATA2 mutations and the development of GATA2 deficiency...
distinct mechanisms. The first step involves phosphorylation of STAG1 or STAG2 in the cohesin complex. The second step involves cleavage of the cohesin...
cohesin complex consisting of RAD21, SMC1A, SMC3, and SCC3 [ STAG1 (SA1) and STAG2 (SA2) in multicellular organisms] proteins, involved in sister chromatid...
Labudina; Julia A Horsfield (7 December 2020). "Cohesin Components Stag1 and Stag2 Differentially Influence Haematopoietic Mesoderm Development in Zebrafish...
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