SilentInformationRegulator (SIR) proteins are involved in regulating gene expression. SIR proteins organize heterochromatin near telomeres,[1] ribosomal DNA (rDNA),[2] and at silent loci including hidden mating type loci in yeast.[3][4] The SIR family of genes encodes catalytic and non-catalytic proteins that are involved in de-acetylation of histone tails and the subsequent condensation of chromatin around a SIR protein scaffold.[5] Some SIR family members are conserved from yeast to humans.
^Palladino F, Laroche T, Gilson E, Axelrod A, Pillus L, Gasser SM (November 1993). "SIR3 and SIR4 proteins are required for the positioning and integrity of yeast telomeres". Cell. 75 (3): 543–555. doi:10.1016/0092-8674(93)90388-7. PMID 8221893. S2CID 21469566.
^Smith JS, Boeke JD (January 1997). "An unusual form of transcriptional silencing in yeast ribosomal DNA". Genes & Development. 11 (2): 241–254. doi:10.1101/gad.11.2.241. PMID 9009206.
^Rine J, Strathern JN, Hicks JB, Herskowitz I (December 1979). "A suppressor of mating-type locus mutations in Saccharomyces cerevisiae: evidence for and identification of cryptic mating-type loci". Genetics. 93 (4): 877–901. doi:10.1093/genetics/93.4.877. PMC 1214119. PMID 397913.
^Haber JE, George JP (September 1979). "A mutation that permits the expression of normally silent copies of mating-type information in Saccharomyces cerevisiae". Genetics. 93 (1): 13–35. doi:10.1093/genetics/93.1.13. PMC 1217820. PMID 16118901.
^Thurtle DM, Rine J (February 2014). "The molecular topography of silenced chromatin in Saccharomyces cerevisiae". Genes & Development. 28 (3): 245–258. doi:10.1101/gad.230532.113. PMC 3923967. PMID 24493645.
Silent Information Regulator (SIR) proteins are involved in regulating gene expression. SIRproteins organize heterochromatin near telomeres, ribosomal...
student with Ira Herskowitz Rine codiscovered yeast SIRproteins, conserved chromatin organizing proteins that modulate gene expression across taxa. As a...
G proteins, also known as guanine nucleotide-binding proteins, are a family of proteins that act as molecular switches inside cells, and are involved...
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the Cavendish Laboratory to investigate the structure of haem-containing proteins. Kendrew was born in Oxford, son of Wilfrid George Kendrew, reader in climatology...
cell behaviour. Hidden mating type loci are epigenetically silenced by SIRproteins, which form a heterochromatin scaffold that prevents transcription from...
radioactive methionine was uptaken into the cells and used to make proteins. From the samples, proteins were precipitated and then separated by mass into distinct...
infectious forms of proteins. In general, proteins fold into discrete units that perform distinct cellular functions, but some proteins are also capable...
however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. The protein encoded by this gene is...
Sir Gregory Paul Winter CBE FRS FMedSci (born 14 April 1951) is a Nobel Prize-winning English molecular biologist best known for his work on the therapeutic...
focus on the structure, stability and activity of proteins and engineering of antibodies. Centre for Protein Engineering was established in 1990 as one of...
composed of a wide array of proteins and plays several roles. The first stage of heterochromatin formation requires DNA binding proteins, which interact with...
F-box protein, which varies. Around 70 human F-box proteins have been identified. F-box proteins contain an F-box, which binds the rest of the SCF complex...
The family of heterochromatin protein 1 (HP1) ("Chromobox Homolog", CBX) consists of highly conserved proteins, which have important functions in the cell...
him to use the X-ray diffraction method to study the structure of proteins. As protein crystals were difficult to obtain, he used horse haemoglobin crystals...
Phillips 1979, p.118 Bragg, Sir Lawrence; J. C. Kendrew; M. F. Perutz (1950). "Polypeptide chain configurations in crystalline proteins". Proc. R. Soc. Lond...
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and proteins, essential macromolecules of life. Proteins are made of amino acids arranged in a linear chain joined by peptide bonds. Many proteins are...
in the presence of a SET domain, which is a type of protein domain. Human genes encoding proteins with histone methyltransferase activity include: ASH1L...
Sir Frederick Gowland Hopkins OM FRS (20 June 1861 – 16 May 1947) was an English biochemist who was awarded the Nobel Prize in Physiology or Medicine...
to be incorporated into proteins during translation, in certain organisms: Selenocysteine is incorporated into some proteins at a UGA codon, which is...
of a protein with multiple peptide subunits, like hemoglobin with its four subunits. Not all proteins have more than one subunit. Ingested proteins are...
Sir Paul Maxime Nurse OM CH FRS FMedSci HonFREng HonFBA MAE (born 25 January 1949) is an English geneticist, former President of the Royal Society and...
Sir Frederick Grant Banting KBE MC FRS FRSC FRCS FRCP (November 14, 1891 – February 21, 1941) was a Canadian pharmacologist, orthopedist, and field surgeon...
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