Colworth Medal (1986) EMBO Member (1987)[1] Louis-Jeantet Prize for Medicine (1989)[2] Knight Bachelor (2004) Royal Medal (2011) Prince Mahidol Award (2016)[3] Nobel Prize in Chemistry (2018)
Scientific career
Fields
Biochemistry
Institutions
University of Cambridge Laboratory of Molecular Biology Imperial College London
Thesis
The amino acid sequence of tryptophanyl tRNA synthetase from Bacillus stearothermophilus(1977)
Doctoral advisor
Brian S. Hartley
Sir Gregory Paul WinterCBE FRS FMedSci (born 14 April 1951)[6][7] is a Nobel Prize-winning English molecular biologist best known for his work on the therapeutic use of monoclonal antibodies. His research career has been based almost entirely at the MRC Laboratory of Molecular Biology and the MRC Centre for Protein Engineering, in Cambridge, England.
He is credited with having invented techniques to both humanize (1986) and, later, to fully humanize using phage display, antibodies for therapeutic uses.[5][8][9][10][11][12][13] Previously, antibodies had been derived from mice, which made them difficult to use in human therapeutics because the human immune system had anti-mouse reactions to them.[6][14][15][16][17][18] For these developments Winter was awarded the 2018 Nobel Prize in Chemistry along with George Smith and Frances Arnold.[19][20]
He is a Fellow of Trinity College, Cambridge and was appointed Master of Trinity College, Cambridge on 2 October 2012, remaining in office until 2019. From 2006 to 2011, he was Deputy Director of the Laboratory of Molecular Biology, Medical Research Council, acting Director from 2007 to 2008 and Head of the Division of Protein and Nucleic Acids Chemistry from 1994 to 2006. He was also Deputy Director of the MRC Centre for Protein Engineering from 1990 to its closure in 2010.[21][22]
^"EMBO MEMBER: Gregory P. Winter". people.embo.org.
^"Doctor Gregory P. WINTER | Jeantet". 1 October 2017.
^"Announcement of the Prince Mahidol Award 2016". princemahidolaward.org. Archived from the original on 14 November 2017. Retrieved 13 June 2017.
^Cite error: The named reference domantis was invoked but never defined (see the help page).
^ abThe Scientific Founders Archived 13 September 2011 at the Wayback Machine of Bicycle Therapeutics Ltd. – Christian Heinis and Sir Greg Winter, FRS.
^ ab"WINTER, Sir Gregory (Paul)". Who's Who. Vol. 2016 (online Oxford University Press ed.). A & C Black. (Subscription or UK public library membership required.)
^"Sir Gregory P. Winter – Facts – 2018". NobelPrize.org. Nobel Media AB. 6 October 2018. Retrieved 6 October 2018.
^"Trinity College Cambridge". Archived from the original on 6 March 2012.
^Gregory Winter's publications indexed by the Scopus bibliographic database. (subscription required)
^Winter, G; Griffiths, A. D.; Hawkins, R. E.; Hoogenboom, H. R. (1994). "Making antibodies by phage display technology". Annual Review of Immunology. 12: 433–455. doi:10.1146/annurev.iy.12.040194.002245. PMID 8011287.
^Griffiths, A. D.; Williams, S. C.; Hartley, O; Tomlinson, I. M.; Waterhouse, P; Crosby, W. L.; Kontermann, R. E.; Jones, P. T.; Low, N. M.; Allison, T. J. (1994). "Isolation of high affinity human antibodies directly from large synthetic repertoires". The EMBO Journal. 13 (14): 3245–60. doi:10.1002/j.1460-2075.1994.tb06626.x. PMC 395221. PMID 8045255.
^Hoogenboom, H. R.; Griffiths, A. D.; Johnson, K. S.; Chiswell, D. J.; Hudson, P.; Winter, G. (1991). "Multi-subunit proteins on the surface of filamentous phage: Methodologies for displaying antibody (Fab) heavy and light chains". Nucleic Acids Research. 19 (15): 4133–4137. doi:10.1093/nar/19.15.4133. PMC 328552. PMID 1908075.
^Anon (2011). "The inventor of humanized monoclonal antibodies and cofounder of Cambridge Antibody Technology, Greg Winter, muses on the future of antibody therapeutics and UK life science innovation". Nature Biotechnology. 29 (3): 190. doi:10.1038/nbt.1815. PMID 21390009. S2CID 205275386.
^Winter, G.; Fields, S.; Brownlee, G. G. (1981). "Nucleotide sequence of the haemagglutinin gene of a human influenza virus H1 subtype". Nature. 292 (5818): 72–5. Bibcode:1981Natur.292...72W. doi:10.1038/292072a0. PMID 7278968. S2CID 4312205.
^Fields, S.; Winter, G.; Brownlee, G. G. (1981). "Structure of the neuraminidase gene in human influenza virus A/PR/8/34". Nature. 290 (5803): 213–7. Bibcode:1981Natur.290..213F. doi:10.1038/290213a0. PMID 7010182. S2CID 8051512.
^Riechmann, L.; Clark, M.; Waldmann, H.; Winter, G. (1988). "Reshaping human antibodies for therapy". Nature. 332 (6162): 323–7. Bibcode:1988Natur.332..323R. doi:10.1038/332323a0. PMID 3127726. S2CID 4335569.
^Marks, J. D.; Hoogenboom, H. R.; Bonnert, T. P.; McCafferty, J.; Griffiths, A. D.; Winter, G. (1991). "By-passing immunization". Journal of Molecular Biology. 222 (3): 581–97. doi:10.1016/0022-2836(91)90498-U. PMID 1748994.
^"Live blog: direction evolution takes chemistry Nobel prize". Retrieved 3 October 2018.
^"Nobel Prize in Chemistry 2018 – live". The Guardian. 3 October 2018. Retrieved 3 October 2018.
^"Sir Gregory Winter Chairman". Archived from the original on 29 January 2012.
^"Greg Winter wins 2018 Nobel Prize for Chemistry – MRC Laboratory of Molecular Biology". MRC Laboratory of Molecular Biology. 3 October 2018. Retrieved 7 October 2018.
Sir Gregory Paul Winter CBE FRS FMedSci (born 14 April 1951) is a Nobel Prize-winning English molecular biologist best known for his work on the therapeutic...
Archived from the original on 23 March 2017. Retrieved 15 December 2013. Gregory, R. L.; Murrell, J. N. (2006). "Hugh Christopher Longuet-Higgins. 11 April...
to Handwritten Zip Code Recognition, Neural Computation, 1(4):541–551, Winter 1989. Yann LeCun, J. S. Denker, S. Solla, R. E. Howard and L. D. Jackel:...
Prize in Physiology or Medicine in 1984 for the discovery. In 1988, GregoryWinter and his team pioneered the techniques to humanize monoclonal antibodies...
2011: Joseph Altman, Arturo Álvarez-Buylla and Giacomo Rizzolatti 2012: GregoryWinter and Richard A. Lerner 2013: Peter Higgs, François Englert and European...
one of the founders of Cambridge Antibody Technology alongside Sir GregoryWinter and David Chiswell. He is well known as one of the inventors of scFv...
Gregory of Nyssa, also known as Gregory Nyssen (Greek: Γρηγόριος Νύσσης or Γρηγόριος Νυσσηνός; c. 335 – c. 394), was Bishop of Nyssa in Cappadocia from...
Gregory House is a fictional character and the titular protagonist of the American medical drama series House. Created by David Shore and portrayed by...
Isabella Augusta, Lady Gregory (née Persse; 15 March 1852 – 22 May 1932) was an Anglo-Irish dramatist, folklorist and theatre manager. With William Butler...
the award, with the other half jointly awarded to George Smith and GregoryWinter "for the phage display of peptides and antibodies." She is the first...
Gregory Maguire (born June 9, 1954) is an American novelist. He is the author of Wicked, Confessions of an Ugly Stepsister, and several dozen other novels...
Chemistry to Frances Arnold for evolution of enzymes, and George Smith and GregoryWinter for phage display. Successful labeling of a molecule of interest requires...
Gregory Neale Harrison (born May 31, 1950) is an American actor. He is known primarily for his roles as Dr. George Alonzo "Gonzo" Gates, the young surgeon...
The Gregory Brothers are an American musical quartet, specializing in comedy music and auto-tuning recorded speech through their YouTube channel Schmoyoho...
Gregory Palamas (Greek: Γρηγόριος Παλαμᾶς; c. 1296 – 1359) was a Byzantine Greek theologian and Eastern Orthodox cleric of the late Byzantine period....
Pope Gregory IX (Latin: Gregorius IX; born Ugolino di Conti; 1145 – 22 August 1241) was head of the Catholic Church and the ruler of the Papal States...
Gregory Mertens (2 February 1991 – 30 April 2015) was a Belgian professional football player. His usual position was central defender. He began his senior...
After the Gregory property was bought for the national park in 1935, the Gregory family was given a "lifetime dowry," and the owner, J. J. Gregory's wife,...
Bradley, Michael Houghton (award declined), Stephen Joseph Elledge, GregoryWinter 2014 James P. Allison, Titia de Lange, Marc Feldmann, Ravinder Nath...