Rutecarpine information

Rutecarpine
Names
	Preferred IUPAC name 8,13-Hydroindolo[2′,3′:3,4]pyrido[2,1-b]quinazolin-5(7H)-one
Identifiers
CAS Number	84-26-4 ;
3D model (JSmol)	Interactive image;
ChEBI	CHEBI:8922;
ChEMBL	ChEMBL85139;
ChemSpider	59175;
ECHA InfoCard	100.163.752
EC Number	635-907-6;
KEGG	C09238;
PubChem CID	65752;
UNII	8XZV289PRY;
CompTox Dashboard (EPA)	DTXSID00232884 ;
	InChI InChI=1S/C18H13N3O/c22-18-13-6-2-4-8-15(13)20-17-16-12(9-10-21(17)18)11-5-1-3-7-14(11)19-16/h1-8,19H,9-10H2 Key: ACVGWSKVRYFWRP-UHFFFAOYSA-N; InChI=1/C18H13N3O/c22-18-13-6-2-4-8-15(13)20-17-16-12(9-10-21(17)18)11-5-1-3-7-14(11)19-16/h1-8,19H,9-10H2 Key: ACVGWSKVRYFWRP-UHFFFAOYAZ;
	SMILES C1CN2C(=NC3=CC=CC=C3C2=O)C4=C1C5=CC=CC=C5N4;
Properties
Chemical formula	C18H13N3O
Molar mass	287.322 g·mol−1
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Infobox references

Rutecarpine or rutaecarpine is a COX-2 inhibitor isolated from Tetradium ruticarpum, a tree native to China.^[1] It is classified as a non-basic alkaloid.^[2]

In contrast to synthetic COX-2 inhibitors like etoricoxib and celecoxib, rutecarpine does not appear to cause negative effects on the cardiovascular system.^[3]

^ Moon, T. C.; Murakami, M.; Kudo, I.; Son, K. H.; Kim, H. P.; Kang, S. S.; Chang, H. W. (1999). "A new class of COX-2 inhibitor, rutaecarpine from Evodia rutaecarpa". Inflammation Research. 48 (12): 621–625. doi:10.1007/s000110050512. PMID 10669112. S2CID 19555209.
^ Manske, R. H. F. (1950). "Sources of alkaloids and their isolation". In Manske, R. H. F.; Holmes, H. L. (eds.). The Alkaloids: Chemistry and Physiology. Vol. 1. Academic Press. pp. 1–14. doi:10.1016/S1876-0813(08)60184-0. ISBN 978-0-12-469501-6. S2CID 82529003.
^ Jia, Sujie; Hu, Changping (2010). "Pharmacological effects of rutaecarpine as a cardiovascular protective agent". Molecules. 15 (3): 1873–1881. doi:10.3390/molecules15031873. PMC 6257227. PMID 20336017. S2CID 21968872.

[1] Moon, T. C.; Murakami, M.; Kudo, I.; Son, K. H.; Kim, H. P.; Kang, S. S.; Chang, H. W. (1999). "A new class of COX-2 inhibitor, rutaecarpine from Evodia rutaecarpa". Inflammation Research. 48 (12): 621–625. doi:10.1007/s000110050512. PMID 10669112. S2CID 19555209.

[2] Manske, R. H. F. (1950). "Sources of alkaloids and their isolation". In Manske, R. H. F.; Holmes, H. L. (eds.). The Alkaloids: Chemistry and Physiology. Vol. 1. Academic Press. pp. 1–14. doi:10.1016/S1876-0813(08)60184-0. ISBN 978-0-12-469501-6. S2CID 82529003.

[3] Jia, Sujie; Hu, Changping (2010). "Pharmacological effects of rutaecarpine as a cardiovascular protective agent". Molecules. 15 (3): 1873–1881. doi:10.3390/molecules15031873. PMC 6257227. PMID 20336017. S2CID 21968872.

Rutecarpine information

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