Mesalazine, also known as mesalamine or 5-aminosalicylic acid (5-ASA), is a medication used to treat inflammatory bowel disease, including ulcerative colitis and Crohn's disease.[1] It is generally used for mildly to moderately severe disease.[1] It is taken by mouth or rectally.[1] The formulations which are taken by mouth appear to be similarly-effective.[12]
Common side-effects include headache, nausea, abdominal pain, and fever.[1] Serious side-effects may include pericarditis, liver problems, and kidney problems.[1][12] Use in pregnancy and breastfeeding appears safe.[12] In people with a sulfa allergy certain formulations may result in problems.[1] Mesalazine is an aminosalicylate and anti-inflammatory.[1][12] It works by direct contact with the intestines.[1]
Mesalazine was approved for medical use in the United States in 1987.[1][8] It is on the World Health Organization's List of Essential Medicines.[13] It is available as a generic medication.[1][14][15][16] In 2021, it was the 239th most commonly prescribed medication in the United States, with more than 1million prescriptions.[17][18]
^ abcdefghijk"Mesalamine Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists.
^"Mesalamine Use During Pregnancy". Drugs.com. 18 September 2018. Retrieved 30 December 2019.
^"Mesalazine Sun/ Mesalz (Sun Pharma ANZ Pty Ltd)". Therapeutic Goods Administration (TGA). 13 January 2023. Retrieved 9 April 2023.
^"Product monograph brand safety updates". Health Canada. February 2024. Retrieved 24 March 2024.
^"Regulatory Decision Summary for Mezera". Drug and Health Products Portal. 5 February 2024. Retrieved 2 April 2024.
^"Drug and medical device highlights 2018: Helping you maintain and improve your health". Health Canada. 14 October 2020. Retrieved 17 April 2024.
^Cite error: The named reference Asacol SmPC was invoked but never defined (see the help page).
^ ab"Asacol HD- mesalamine tablet, delayed release". DailyMed. 15 April 2018. Retrieved 30 December 2019.
^"Pentasa- mesalamine capsule". DailyMed. 8 November 2021. Retrieved 17 May 2022.
^"Lialda- mesalamine tablet, delayed release". DailyMed. 8 November 2021. Retrieved 17 May 2022.
^Human Medicines Evaluation Division (15 October 2020). "Active substance: mesalazine" (PDF). List of nationally authorised medicinal products. European Medicines Agency.
^ abcdBritish national formulary: BNF 76 (76 ed.). Pharmaceutical Press. 2018. pp. 39–41. ISBN 9780857113382.
^World Health Organization (2021). World Health Organization model list of essential medicines: 22nd list (2021). Geneva: World Health Organization. hdl:10665/345533. WHO/MHP/HPS/EML/2021.02.
^"ANDA Approval Reports - 2017 First Generic Drug Approvals". Food and Drug Administration (FDA). 3 November 2018. Retrieved 8 April 2019.
^"2022 First Generic Drug Approvals". U.S. Food and Drug Administration (FDA). 3 March 2023. Archived from the original on 30 June 2023. Retrieved 30 June 2023.
^"Competitive Generic Therapy Approvals". U.S. Food and Drug Administration (FDA). 29 June 2023. Archived from the original on 29 June 2023. Retrieved 29 June 2023.
^"The Top 300 of 2021". ClinCalc. Archived from the original on 15 January 2024. Retrieved 14 January 2024.
^"Mesalamine - Drug Usage Statistics". ClinCalc. Retrieved 14 January 2024.
Mesalazine, also known as mesalamine or 5-aminosalicylic acid (5-ASA), is a medication used to treat inflammatory bowel disease, including ulcerative colitis...
colon, where most of it is metabolized by bacteria into sulfapyridine and mesalazine (also known as 5-aminosalicylic acid or 5-ASA). Both metabolites are active;...
alone, such as Mesalazine, or hydrocortisone enemas. Again, the Mesalazine is preferred for maintenance therapy. Initially a 4 g Mesalazine enema (Rowasa)...
include altering risk factors such as obesity, inactivity, and smoking. Mesalazine and rifaximin appear useful for preventing attacks in those with diverticulosis...
bring about and maintain remission, including aminosalicylates such as mesalazine or sulfasalazine, steroids, immunosuppressants such as azathioprine, and...
among others: 4-Aminosalicylic acid Balsalazide Olsalazine Sulfasalazine Mesalazine (5-Aminosalicylic acid) Side effects may include abdominal pain, diarrhea...
It is usually administered as the disodium salt. Balsalazide releases mesalazine, also known as 5-aminosalicylic acid, or 5-ASA, in the large intestine...
increasing evidence for the effectiveness of mesalazine (5-aminosalicylic acid) in the treatment of IBS. Mesalazine is a drug with anti-inflammatory properties...
elderly, preparing Ayurvedic poly-phytotherapy filed TLPL/AY, psyllium, mesalazine, methylnaltrexone, and oxycodone/naloxone, or to assess the response to...
oxyclozanide, salicylanilide, niclosamide, and raclopride. 4-Aminosalicylic acid Mesalazine Salsalate Borne R, Levi M, Wilson N (2008). "Nonsteroidal Anti-Inflammatory...
number: 554-84-7), a yellow solid (m.p. 97 °C) and precursor to the drug mesalazine (5-aminosalicylic acid). It can be prepared by nitration of aniline followed...
4-Aminosalicylic acid (para-aminosalicylic acid, PAS) 5-Aminosalicylic acid (mesalazine) 6-Aminosalicylic acid This set index article lists chemical compounds...
treatments include short-chain fatty acid irrigation, steroid enemas and mesalazine. For surgical candidates, reanastomosis is a reversal procedure carried...
chemical subgroup (A02BA H2-receptor antagonists) excluding combinations Mesalazine is an alternative Bisacodyl is an alternative In acute diarrhoea zinc...
with lymphocytic colitis. Anti-inflammatory drugs, such as salicylates, mesalazine, and systemic corticosteroids may be prescribed for people who do not...
agents including antidiarrheals, bismuth subsalicylate (Pepto-Bismol), mesalazine/mesalamine (alone or in combination with cholestyramine), systemic corticosteroids...
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