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Roxarsone information


Roxarsone
Skeletal formula of roxarsone
Space-filling model of the roxarsone molecule
Names
Preferred IUPAC name
(4-Hydroxy-3-nitrophenyl)arsonic acid
Identifiers
CAS Number
  • 121-19-7 checkY
3D model (JSmol)
  • Interactive image
  • Interactive image
Beilstein Reference
1976533
ChEBI
  • CHEBI:35817 checkY
ChEMBL
  • ChEMBL1321154
ChemSpider
  • 4925 checkY
ECHA InfoCard 100.004.049 Edit this at Wikidata
EC Number
  • 204-453-7
Gmelin Reference
1221211
KEGG
  • D05771 checkY
MeSH Roxarsone
PubChem CID
  • 5104
RTECS number
  • CY5250000
UNII
  • H5GU9YQL7L checkY
UN number 3465
CompTox Dashboard (EPA)
  • DTXSID9020956 Edit this at Wikidata
InChI
  • InChI=1S/C6H6AsNO6/c9-6-2-1-4(7(10,11)12)3-5(6)8(13)14/h1-3,9H,(H2,10,11,12) checkY
    Key: XMVJITFPVVRMHC-UHFFFAOYSA-N checkY
  • InChI=1/C6H6AsNO6/c9-6-2-1-4(7(10,11)12)3-5(6)8(13)14/h1-3,9H,(H2,10,11,12)
    Key: XMVJITFPVVRMHC-UHFFFAOYAF
SMILES
  • Oc1ccc(cc1[N+](=O)[O-])[As](O)(O)=O
  • OC1=CC=C(C=C1[N+]([O-])=O)[As](O)(O)=O
Properties
Chemical formula
C
6
AsNH
6
O
6
Molar mass 263.0365 g mol−1
Melting point > 300 °C (572 °F; 573 K)
Hazards
GHS labelling:
Pictograms
GHS06: Toxic GHS09: Environmental hazard
Signal word
Danger
Hazard statements
H301, H331, H410
Precautionary statements
P261, P273, P301+P310, P311, P501
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
checkY verify (what is checkY☒N ?)
Infobox references

Roxarsone is an organoarsenic compound that has been used in poultry production as a feed additive to increase weight gain and improve feed efficiency, and as a coccidiostat.[1] As of June 2011, it was approved for chicken feed in the United States, Canada, Australia, and 12 other countries.[2] The drug was also approved in the United States and elsewhere for use in pigs.[1][2]

Its use in the United States was voluntarily ended by the manufacturers in June 2011 and has been illegal since 2013.[3][4] Its use was immediately suspended in Malaysia.[5] It was banned in Canada in August 2011.[6] In Australia, its use in chicken feed was discontinued in 2012.[7] Roxarsone has been banned in the European Union since 1999.[8]

  1. ^ a b U.S. Food and Drug Administration (June 8, 2011). "Questions and Answers Regarding 3-Nitro (Roxarsone)".
  2. ^ a b Harris, Gardiner; Grady, Denise (9 June 2011). "Pfizer Suspends Sales of Chicken Drug". The New York Times. Retrieved 19 October 2018.
  3. ^ Cite error: The named reference withdrawn was invoked but never defined (see the help page).
  4. ^ "Arsenic in Chicken: Does chicken meat contain arsenic?". Chicken Check In. 21 July 2017. Retrieved 20 March 2018.
  5. ^ "Malaysian Pharmaceutical Society". Malaysian Pharmaceutical Society. Retrieved 19 October 2018.
  6. ^ "Sales halted after arsenic found in chicken drug". The Globe and Mail. 3 May 2018. Retrieved 19 October 2018.
  7. ^ "Roxarsone not used in the Australian chicken industry" (PDF). Australian Meat Chicken Federation. 24 May 2018. Retrieved 19 October 2018.
  8. ^ Philpott, Tom (11 June 2011). "Some Arsenic With That Supermarket Chicken?". Mother Jones. Retrieved 19 October 2018.

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Roxarsone

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Roxarsone is an organoarsenic compound that has been used in poultry production as a feed additive to increase weight gain and improve feed efficiency...

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Chicken as food

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factory farming, chickens are routinely administered with the feed additive roxarsone, an organoarsenic compound which partially decomposes into inorganic arsenic...

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Arsenic

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weight gain, improve feed efficiency, and prevent disease. An example is roxarsone, which had been used as a broiler starter by about 70% of U.S. broiler...

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Organometallic chemistry

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methylcyclopentadienyl manganese tricarbonyl (MMT). The organoarsenic compound roxarsone is a controversial animal feed additive. In 2006, approximately one million...

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Coccidiostat

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Maduramicin Monensin Narasin Nicarbazin Oryzalin Ponazuril Robenidine Roxarsone Salinomycin Spiramycin Sulfadiazine Sulfadimethoxine Toltrazuril Coccidiostats...

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Nitarsone

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Nitarsone once was one of four arsenical food-animal drugs—along with roxarsone, arsanilic acid, and carbarsone—approved by the U.S. Food and Drug Administration...

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Poultry farming

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resistance. Poultry feed can include roxarsone or nitarsone, arsenical antimicrobial drugs that also promote growth. Roxarsone was used as a broiler starter...

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Antibiotic use in livestock

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chickens, swine, and turkeys Penicillin Chickens, swine, and turkeys Roxarsone Chickens and turkeys Salinomycin Ionophore Tylosin Chickens and swine...

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Feed additive

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arsenic, often supplied in the form of the organoarsenic compound called roxarsone. It has been used in poultry production to increase weight gain and improve...

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List of veterinary drugs

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infections in foals robenacoxib – nonsteroidal anti-inflammatory drug (NSAID) roxarsone – arsenical used as a coccidiostat and for increased weight gain sarolaner...

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Organoarsenic chemistry

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livestock, including 4-hydroxy-3-nitrobenzenearsonic acid (3-NHPAA or Roxarsone), ureidophenylarsonic acid and p-arsanilic acid. These applications are...

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Arsenic trioxide

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can be given by mouth. Organoarsenic compounds, such as feed additives (roxarsone) and medication (neosalvarsan), are derived from arsenic trioxide.[citation...

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Difluorodioxirane

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Zhenguo; Lin, Chunye; He, Mengchang; Ouyang, Wei (2024). "Efficient roxarsone degradation by low-dose peroxymonosulfate with the activation of recycling...

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Carbarsone

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acid, and roxarsone. In September 2013, the FDA announced that Zoetis and Fleming Laboratories would voluntarily withdraw current roxarsone, arsanilic...

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Arsanilic acid

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among four arsenical veterinary drugs, along with carbarsone, nitarsone, roxarsone, approved by the U.S. Food and Drug Administration (FDA). In 2013, the...

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Bechamp reaction

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commercial application, the Béchamp reaction is reaction is used to produce roxarsone, which exhibits an anticoccidial action and promotes growth in animals...

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Phenylarsonic acid

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feeds. These include 4-hydroxy-3-nitrobenzenearsonic acid (3-NHPAA, or Roxarsone), p-arsanilic acid (p-ASA), 4-nitrophenylarsonic acid (4-NPAA), and...

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Arsenic biochemistry

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Poultry and swine farms make heavy use of the organoarsenic compound roxarsone as an antibiotic in feed. Some wood is treated with copper arsenates as...

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