NADH Dehydrogenase Mechanism: 1. The seven primary iron sulfur centers serve to carry electrons from the site of NADH dehydration to ubiquinone. Note that N7 is not found in eukaryotes. 2. There is a reduction of ubiquinone (CoQ) to ubiquinol (CoQH2). 3. The energy from the redox reaction results in conformational change allowing hydrogen ions to pass through four transmembrane helix channels.
Respiratory complex I, EC 7.1.1.2 (also known as NADH:ubiquinone oxidoreductase, Type I NADH dehydrogenase and mitochondrial complex I) is the first large protein complex of the respiratory chains of many organisms from bacteria to humans. It catalyzes the transfer of electrons from NADH to coenzyme Q10 (CoQ10) and translocates protons across the inner mitochondrial membrane in eukaryotes or the plasma membrane of bacteria.
Respiratory complex I
Identifiers
Symbol
Respiratory complex I
OPM superfamily
246
OPM protein
6g72
Membranome
255
NADH:ubiquinone reductase (H+-translocating).
Identifiers
EC no.
1.6.5.3
Databases
IntEnz
IntEnz view
BRENDA
BRENDA entry
ExPASy
NiceZyme view
KEGG
KEGG entry
MetaCyc
metabolic pathway
PRIAM
profile
PDB structures
RCSB PDB PDBe PDBsum
Gene Ontology
AmiGO / QuickGO
Search
PMC
articles
PubMed
articles
NCBI
proteins
This enzyme is essential for the normal functioning of cells, and mutations in its subunits lead to a wide range of inherited neuromuscular and metabolic disorders. Defects in this enzyme are responsible for the development of several pathological processes such as ischemia/reperfusion damage (stroke and cardiac infarction), Parkinson's disease and others.[citation needed]
and 27 Related for: Respiratory complex I information
RespiratorycomplexI, EC 7.1.1.2 (also known as NADH:ubiquinone oxidoreductase, Type I NADH dehydrogenase and mitochondrial complexI) is the first large...
of respiratorycomplexI". Biochem. J. 425 (2): 327–39. doi:10.1042/BJ20091382. PMID 20025615. Cecchini G (2003). "Function and structure of complex II...
misdirects the EHHADH to the mitochondria. This interferes with respiratorycomplexI and with beta oxidation of fatty acids. The result is a decrease...
transport chains in bacteria, chloroplasts and mitochondria, including respiratorycomplexesI, II and III. Some others can associate with biological membranes...
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or respiratory inhibitors such as antimycin A), Complex III may leak electrons to molecular oxygen, resulting in superoxide formation. This complex is...
A respiratory pigment is a metalloprotein that serves a variety of important functions, its main being O2 transport. Other functions performed include...
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Stuchebrukhov, Alexei A. (2011-05-12). "Quantum Electron Tunneling in RespiratoryComplexI". The Journal of Physical Chemistry B. 115 (18): 5354–5364. doi:10...
and hypothalamus. Medulla ventral respiratory group (includes the pre-Bötzinger complex). The ventral respiratory group controls voluntary forced exhalation...
Tyler J. (2021-06-18). "Phylogeny and Evolutionary History of RespiratoryComplexI Proteins in Melainabacteria". Genes. 12 (6): 929. doi:10.3390/genes12060929...
mammals, the Bötzinger complex (BötC) is a group of neurons located in the rostral ventrolateral medulla, and ventral respiratory column. In the medulla...
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Sazanov is known for the discovery of the first atomic structure of respiratorycomplexI, using X-ray crystallography and the bacterial enzyme as a model...
main research interest is mitochondrial complexI. Hirst has been published in 2018 on Open questions: respiratory chain supercomplexes – why are they there...
subunit I (CO1 or MT-CO1) is one of three mitochondrial DNA (mtDNA) encoded subunits (MT-CO1, MT-CO2, MT-CO3) of respiratorycomplex IV. Complex IV is the...
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functionally active and necessary for forming stable respiratorycomplexes. One supercomplex of complexI, III, and IV make up a unit known as a respirasome...
and inhibition of enzymes in the electron transport chain such as respiratorycomplexI (NADH ubiquinone oxidoreductase), and this may be the reason for...
which is reduced by the preceding component of the respiratory chain (cytochrome bc1 complex, Complex III), docks near the CuA binuclear center and passes...
mitochondrial membrane respiratory chain NADH dehydrogenase (ComplexI), the first oligomeric enzymatic complex of the mitochondrial respiratory chain located...
the growth of the respiratory bud possible is complex and involves a number of interactions between the mesoderm and the respiratory bud epithelium, in...
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