detection of chemical stimulus involved in sensory perception of pain
response to stimulus
ion transport
response to organic substance
cell surface receptor signaling pathway
response to pain
calcium ion transmembrane transport
response to cold
sensory perception of pain
protein homotetramerization
response to hydrogen peroxide
thermoception
calcium ion transport
detection of mechanical stimulus involved in sensory perception of pain
release of sequestered calcium ion into cytosol
transmembrane transport
ion transmembrane transport
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
8989
277328
Ensembl
ENSG00000104321
ENSMUSG00000032769
UniProt
O75762
Q8BLA8
RefSeq (mRNA)
NM_007332
NM_177781 NM_001348288
RefSeq (protein)
NP_015628
NP_808449 NP_001335217
Location (UCSC)
Chr 8: 72.02 – 72.08 Mb
Chr 1: 14.94 – 14.99 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Transient receptor potential cation channel, subfamily A, member 1, also known as transient receptor potential ankyrin 1, TRPA1, or The Wasabi Receptor, is a protein that in humans is encoded by the TRPA1 (and in mice and rats by the Trpa1) gene.[5][6]
TRPA1 is an ion channel located on the plasma membrane of many human and animal cells. This ion channel is best known as a sensor for pain, cold and itch in humans and other mammals, as well as a sensor for environmental irritants giving rise to other protective responses (tears, airway resistance, and cough).[7][8]
^ abcGRCh38: Ensembl release 89: ENSG00000104321 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000032769 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Jaquemar D, Schenker T, Trueb B (March 1999). "An ankyrin-like protein with transmembrane domains is specifically lost after oncogenic transformation of human fibroblasts". The Journal of Biological Chemistry. 274 (11): 7325–33. doi:10.1074/jbc.274.11.7325. PMID 10066796.
^Clapham DE, Julius D, Montell C, Schultz G (December 2005). "International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels". Pharmacological Reviews. 57 (4): 427–50. doi:10.1124/pr.57.4.6. PMID 16382100. S2CID 17936350.
^Andersen HH, Elberling J, Arendt-Nielsen L (September 2015). "Human surrogate models of histaminergic and non-histaminergic itch". Acta Dermato-Venereologica. 95 (7): 771–7. doi:10.2340/00015555-2146. PMID 26015312.
^Højland CR, Andersen HH, Poulsen JN, Arendt-Nielsen L, Gazerani P (September 2015). "A human surrogate model of itch utilizing the TRPA1 agonist trans-cinnamaldehyde" (PDF). Acta Dermato-Venereologica. 95 (7): 798–803. doi:10.2340/00015555-2103. PMID 25792226. S2CID 10418526.
ankyrin 1, TRPA1, or The Wasabi Receptor, is a protein that in humans is encoded by the TRPA1 (and in mice and rats by the Trpa1) gene. TRPA1 is an ion...
hypothesized to cause headaches by influencing the trigeminovascular system via TRPA1. Umbellularia californica is a tree native to California and Southern Oregon...
it is significantly more potent than THC or THCV as an activator of the TRPA1 calcium channel which plays an important role in pain perception, and it...
The sensory neural target of mustard oil is the chemosensory receptor, TRPA1, also known as the wasabi receptor. The unique flavour of wasabi is a result...
of waterwitch. Like TRPA1 and other TRP channels, these function as ion channels in a number of sensory systems. TRPA- or TRPA1-like channels also exists...
This pungency and the lachrymatory effect of AITC are mediated through the TRPA1 and TRPV1 ion channels. It is slightly soluble in water, but more soluble...
associated with the exposure to tear gas are often require medical attention. TRPA1 ion channels expressed on nociceptors have been implicated as the site of...
potently activates TRPA1. In a subsequent study, she demonstrated that compounds found in garlic plants, allicin and DADs, also activate TRPA1. Interestingly...
though in vivo effects have not been demonstrated. CBC acts on the TRPV1 and TRPA1 receptors, interfering with their ability to break down endocannabinoids...
atoms, for example, in the fluorination reagent F-TEDA-BF4. Nucleophile TRPA1, the sensory neural target for electrophilic irritants in mammals. "Nucleophiles...
(nociception). In primary afferent sensory neurons, it cooperates with TRPA1 (a chemical irritant receptor) to mediate the detection of noxious environmental...
professionals and police. In addition, repeated exposure may cause sensitisation. TRPA1 (Transient Receptor Potential-Ankyrin 1) ion channel expressed on nociceptors...
DGLα, and an inhibitor of anandamide transport, as well as an agonist of TRPA1 and TRPV2. Many THCA reagents used in biochemistry experiments are contaminated...
taste upon skin contact with DMSO may be due to nonolfactory activation of TRPA1 receptors in trigeminal ganglia. Unlike dimethyl and diallyl disulfides...
vasomotor manifestations of individual and combined stimulation of TRPM8 and TRPA1 using topical L-menthol and trans-cinnamaldehyde in healthy volunteers"...
isothiocyanate. The pungency of allyl isothiocyanate is due to the activation of the TRPA1 ion channel in sensory neurons. White mustard (Brassica hirta) does not...
or long TRPs, ankyrin (whose only member is the transmembrane protein 1 [TRPA1]) TRPN after the nonmechanoreceptor potential C (nonpC), and the more distant...
2014-10-17. Nassini, R.; et al. (2011). "The 'headache tree' via umbellulone and TRPA1 activates the trigeminovascular system". Brain. 135 (2): 376–90. doi:10...
chemicals also directly activate an itch receptor in the skin known as TRPA1. The industrial manufacturing and use of both xylene and diisocyanates greatly...
five deaths, which have resulted from pulmonary injury and/or asphyxia. TRPA1 (Transient Receptor Potential-Ankyrin 1) ion channel expressed on nociceptors...
acetylcholine receptor antagonist NMDA receptor antagonist (very weak) TRPA1 inhibitor Tramadol acts on the opioid receptors through its major active...
SunWook; Patapoutian, Ardem (2005). "The Pungency of Garlic: Activation of TRPA1 and TRPV1 in Response to Allicin" (PDF). Current Biology. 15 (10) (published...
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