In cell biology, efferocytosis (from efferre, Greek for 'to take to the grave', 'to bury') is the process by which apoptotic cells are removed by phagocytic cells. It can be regarded as the 'burying of dead cells'.[1][2]
During efferocytosis, the cell membrane of phagocytic cells engulfs the apoptotic cell, forming a large fluid-filled vesicle containing the dead cell. This ingested vesicle is called an efferosome (in analogy to the term phagosome). This process is similar to macropinocytosis.
^deCathelineau AM, Henson PM (2003). "The final step in programmed cell death: phagocytes carry apoptotic cells to the grave". Essays in Biochemistry. 39: 105–117. doi:10.1042/bse0390105. PMID 14585077.
^Kojima Y, Weissman IL, Leeper NJ (January 2017). "The Role of Efferocytosis in Atherosclerosis". Circulation. 135 (5): 476–489. doi:10.1161/CIRCULATIONAHA.116.025684. PMC 5302553. PMID 28137963.
growth-promoting effects. Conversely, impaired efferocytosis has been linked to autoimmune disease and tissue damage. Efferocytosis results in production by the ingesting...
-Cytosis is a suffix that either refers to certain aspects of cells ie cellular process or phenomenon or sometimes refers to predominance of certain type...
up into the surrounding tissues by macrophages in a process called efferocytosis. One of the features of an apoptotic cell is the presentation of a variety...
removal of dead cells by neighboring phagocytic cells has been termed efferocytosis. Dying cells that undergo the final stages of apoptosis display phagocytotic...
from the body both during homeostasis and disease by the process of 'efferocytosis'. Efferocytic removal of apoptotic cells is usually done by neighboring...
proinflammatory mediator expression. C15 was found to promote phagocytosis and efferocytosis in peritoneal macrophages at picomolar concentrations. C15 enhanced...
WB, Penberthy KK, Arandjelovic S, Blumberg RS, et al. (June 2021). "Efferocytosis by Paneth cells within the intestine". Current Biology. 31 (11): 2469–2476...
face, can serve as an early indicator of apoptosis and as a signal for efferocytosis. Lipid transporters transport or flip lipids across the bilayers. There...
abating neuropathic pain. MaR1 enhances the uptake (i.e. stimulates the efferocytosis) of apoptotic human neutrophils by human macrophages, stimulates macrophage...
apoptotic neutrophils and eosinophils from inflammatory sites (see Efferocytosis) either by direct effecting these cells or by stimulating NK cells to...
peritoneum in a mouse model of inflammatory disease; b) stimulate the Efferocytosis (i.e. engulfment and removal) of neutrophils; and c) reduce brain infarction...
same model showed that this particular molecule enhances macrophage efferocytosis (phagocyting apoptotic cells). CCX832 is an orally active molecule used...
effect of serum amyloid a in the induction of macrophage M2 markers and efferocytosis of apoptotic neutrophils". Journal of Immunology. 194 (10): 4891–900...
PM, Bratton DL (April 2011). "Signaling via macrophage G2A enhances efferocytosis of dying neutrophils by augmentation of Rac activity". The Journal of...
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